Making Blood: The Haematopoietic Niche throughout Ontogeny

Al-Drees, Mohammad A.; Yeo, Jia Hao; Boumelhem, Badwi B.; Antas, Veronica I.; Brigden, Kurt W. L.; Colonne, Chanukya K.; Fraser, Stuart T.

doi:10.1155/2015/571893

Cited by 23 publications

(25 citation statements)

References 145 publications

(196 reference statements)

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“…During embryonic development, blood cell production (hematopoiesis) is not limited to one site but can be found in a range of locations which vary with the developmental age [38–40]. This occurs due to the migration of hematopoietic progenitors throughout the conceptus.…”

Section: Perspectives / Future Directionsmentioning

confidence: 99%

“…This migration requires the formation of supportive microenvironments, termed hematopoietic niches [41]. Hematopoietic activity can be identified in the extraembryonic yolk sac; dorsal aorta-gonad-mesonephros (AGM region); placenta; vitelline and umbilical arteries; fetal liver; spleen; and in the skeletal muscle surrounding the developing long bones [38, 39, 42–53]. Hematopoietic progenitors from the fetal liver subsequently migrate via the circulation finally to the bone marrow preceding birth, and the bone marrow becomes the predominant location for hematopoiesis throughout the adult life [54].…”

Section: Perspectives / Future Directionsmentioning

confidence: 99%

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Lung as a Niche for Hematopoietic Progenitors

Borges

Sena

Azevedo

et al. 2017

Stem Cell Rev and Rep

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Platelets are released from megakaryocytes. The bone marrow has been proposed to be the major site where this process occurs. Lefrançais et al. (2017) using state-of-the-art techniques including two-photon microscopy, in vivo lineage-tracing technologies, and sophisticated lung transplants reveal that the lung is also a primary site for platelet biogenesis. Strikingly, lung megakaryocytes can completely reconstitute platelet counts in the blood in mice with thrombocytopenia. This study also shows that hematopoietic progenitors, with capacity to repopulate the bone marrow after irradiation, are present in the lungs. This work brings a novel unexpected role for the lung as a niche for hematopoiesis. The emerging knowledge from this research may be important for the treatment of several disorders.

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Section: Perspectives / Future Directionsmentioning

confidence: 99%

Section: Perspectives / Future Directionsmentioning

confidence: 99%

Lung as a Niche for Hematopoietic Progenitors

Borges

Sena

Azevedo

et al. 2017

Stem Cell Rev and Rep

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“…During mammalian embryonic development, hematopoiesis is not limited to one site but can be found in a range of locations which vary with the developmental age of the embryo or fetus [123]. This migration of hematopoietic stem cells (HSC) throughout the conceptus (the yolk sac, placenta and embryo/fetus combined) is dependent upon the embryonic stage of development and requires the formation of supportive microenvironments, termed hematopoietic niches.…”

Section: Introductionmentioning

confidence: 99%

“…This migration of hematopoietic stem cells (HSC) throughout the conceptus (the yolk sac, placenta and embryo/fetus combined) is dependent upon the embryonic stage of development and requires the formation of supportive microenvironments, termed hematopoietic niches. Ontogenetically, hematopoietic activity can be identified in the extra-embryonic yolk sac; dorsal aorta at the level of the gonad-mesonephros (AGM); placenta; vitelline and omphalomesenteric arteries; fetal liver, spleen; skeletal muscle surrounding the developing long bones; and finally in the bone marrow [12456]. Embryonic hematopoiesis can be divided into primitive (fetal) and definitive (adult-type) hematopoiesis.…”

Section: Introductionmentioning

confidence: 99%

Regulation of the embryonic erythropoietic niche: a future perspective

2017

Self Cite

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The production of red blood cells, termed erythropoiesis, occurs in two waves in the developing mouse embryo: first primitive erythropoiesis followed by definitive erythropoiesis. In the mouse embryo, both primitive and definitive erythropoiesis originates in the extra-embryonic yolk sac. The definitive wave then migrates to the fetal liver, fetal spleen and fetal bone marrow as these organs form. The fetal liver serves as the major organ for hematopoietic cell expansion and erythroid maturation after mid-gestation. The erythropoietic niche, which expresses critical cytokines such as stem cell factor (SCF), thrombopoietin (TPO) and the insulin-like growth factors IGF1 and IGF2, supports hematopoietic expansion in the fetal liver. Previously, our group demonstrated that DLK1+ hepatoblasts support fetal liver hematopoiesis through erythropoietin and SCF release as well as extracellular matrix deposition. Loss of DLK1+ hepatoblasts in Map2k4−/− mouse embryos resulted in decreased numbers of hematopoietic cells in fetal liver. Genes encoding proteinases and peptidases were found to be highly expressed in DLK1+ hepatoblasts. Capitalizing on this knowledge, and working on the assumption that these proteinases and peptidases are generating small, potentially biologically active peptides, we assessed a range of peptides for their ability to support erythropoiesis in vitro. We identified KS-13 (PCT/JP2010/067011) as an erythropoietic peptide-a peptide which enhances the production of red blood cells from progenitor cells. Here, we discuss the elements regulating embryonic erythropoiesis with special attention to niche cells, and demonstrate how this knowledge can be applied in the identification of niche-derived peptides with potential therapeutic capability.

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“…Moreover, the embryonic MSCs circulate in the blood. Thus concerted localization of MSCs and HSCs on the definite areas in ontogenesis evidences for possible cooperation of these cells during hematopoiesis [19,20].…”

Section: Hematopoietic Stem Cells -Self-maintenance and Multipotencymentioning

confidence: 96%

Structural-functional organisation of the bone marrow hematopoietic stem cells niches

Nikolskaya¹,

Butenko²

2016

JCOT

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This article focuses on (1) the analysis of the structural-functional organization of bone marrow niches of the hematopoietic stem cells, (2) the role of the intercellular contact interactions and humoral regulation factors in these niches, in particular CXCL12, SCF and TGFβ,and (3) KEYWORDS: bone marrow, hematopoietic stem cell niche, multipotent stromal cells, hematopoiesisMaksimov and finally established at the end of the past century, it is not only the number but also entire known diversity of cell elements of immune and blood systems originate from only one type of the progenitor elements -the HSCs (unitary theory) [2].Life force and productivity of the HSCs is proved, for example, by the fact that 99.9 % of all blood-generating cells, HSCs included, in the irradiated mice can perish, and the surviving stem cells rapidly renew blood formation, including proper population as well as all types of the committed progenitors [3]. Along same sequence, the fact of non-exhaustion of blood formation after repeated damaging exposures is explained by the presence and functioning of the HSCs [1].The specialized cells of adult and fetal periods of ontogenesis, residing in the bone marrow (BM) in the quiescent state and capable, together with blood-forming microenvironment, to realize underlying programs for self-maintenance and multipotency allowing them (with maintained amount of HSCs) to release necessary amount of cells into differentiation along various directions that ultimately leads to the formation of all forms of blood elements, including immune system cells. It should be noted that the self-maintenance is not identical to the immortality. Stem cells are characterized by sufficiently long life, commensurable with entire organism's life course. Several genetic regulatory programs have been established which are of great importance in the process of HSCs self-maintenance. It is also known that stem cells in various tissues are controlled by common genetic programs maintaining their nature [4,5].It is theorized that stem cells are the clonogenic units which under certain conditions can be increased in their number at the expense Immune system is the structural-functional and interrelated commonness of the hematopoietic and stromal cells. Different in their origin, structure and functions, the populations and subpopulations of lymphoid and myeloid cells make a complete wholeness in the definite tissues and organs where they closely cooperate with non-hematopoietic elements. Constant and strictly regulated intensity of hematopoiesis with production of various cell types is also conditioned and controlled by cooperation of the hematopoietic and stromal cells. Timely repopulation of the immune system with hematopoietic cells-precursors, lymphocytes, leucocytes and stromal cells, newly maturing in the bone marrow, is the main condition for effective immune system functioning. The number of cells formed per time unit is plentiful. According to the given data, nearly 10 11 neutrophils (about 100 g of mass) per...

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Making Blood: The Haematopoietic Niche throughout Ontogeny

Cited by 23 publications

References 145 publications

Lung as a Niche for Hematopoietic Progenitors

Lung as a Niche for Hematopoietic Progenitors

Regulation of the embryonic erythropoietic niche: a future perspective

Structural-functional organisation of the bone marrow hematopoietic stem cells niches

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