Malabsorption of Vitamin B<sub>12</sub> During Treatment with Para‐amino salicylic Acid

Heinivaara, O; Palva, I. P.

doi:10.1111/j.0954-6820.1964.tb00595.x

Cited by 31 publications

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“…The serum vitamin BI2 levels of patients who had been treated with antituberculous drugs for long periods were also examined in the present series. The levels were within normal range, and the results obtained failed to corroborate the findings reported by Heinivaara & Palva (1964). Nor were their findings confirmed by Roberts et al (1966) , Meyer (1966), and Paaby & Norvin (1 966).…”

Section: Discussionmentioning

confidence: 64%

Folic Acid and Vitamin B₁₂ in Tuberculosis

Markkanen

Levanto

Sallinen

et al. 1967

Scandinavian Journal of Haematology

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The present investigation covered 231 tuberculous patients, 200 healthy control subjects and 65 patients of a medical ward. The folate levels in serum and whole blood proved to be lower among the tuberculous than in the control group. Oral folate clearance tests gave an abnormal result for two‐fifths of the tuberculous patients examined. Over half the number of the patients whose bone marrow was examined showed various degrees of intermediate megaloblastic changes, though none had such pronounced megaloblastic changes as are common in vitamin B12 deficiency. The patients who had mild or obvious megaloblastic changes in bone marrow also showed lower serum folate levels than those whose bone marrow was normal showed only minimal changes. The serum folate levels, however, varied considerably within all the groups of bone marrow types. The part played by antituberculous drugs (PAS‐INH) in the folate deficiency requires continued study. The serum levels of vitamin B12 in tuberculous patients were within the normal range.

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Section: Discussionmentioning

confidence: 64%