Maladie cœliaque et accidents vasculaires cérébraux ischémiques

Moutawakil, Bouchra El; Chourkani, N.; Sibai, M.; Moutaouakil, F.; Rafai, M.A.; Bourezgui, M.

doi:10.1016/j.neurol.2008.09.002

Cited by 13 publications

(15 citation statements)

References 19 publications

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“…The pathophysiology of the thromboembolic phenomena associated with CD [10-26] represents a puzzle with multiple constituents: hyperhomocysteinemia; B12 and\or folate deficiency; methylenetetrahydrofolate reductase mutations; the high homology between blood coagulation factor XIII and tTG; and protein C and S deficiency due to vitamin K deficiency [21-26,54]. The present study unravels a series of autoantibodies, aPL, aPT and mainly aPS/PT, that form part of this puzzle and are suggested to play a pathogenic role in the thrombogenicity of CD.…”

Section: Discussionmentioning

confidence: 99%

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The thrombophilic network of autoantibodies in celiac disease

Lerner

Agmon‐Levin

Shapira

et al. 2013

BMC Med

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BackgroundCeliac disease is a life-long autoimmune condition, affecting genetically susceptible individuals that may present with thromboembolic phenomena. This thrombophilia represents a puzzle with multiple constituents: hyperhomocysteinemia, B12 and\or folate deficiency, methylenetetrahydrofolate reductase mutations, and protein C and S deficiency due to vitamin K deficiency. However, the well known thrombogenic factors, antiphosphatidylserine/prothrombin and antiprothrombin have never been explored in celiac disease.MethodsThe serum autoantibody levels were determined in 248 individuals, classified into three groups. Group 1 comprised 70 children with definitive celiac disease (age: 7.04 ±4.3 years, male to female ratio 1.06) and group 2 comprised 88 normal children (age: 6.7 ±4.17 years, male to female ratio 0.87), representing controls. The pediatric populations were compared to group 3, which included 90 adults who were family members (parents) of group 1 (age: 34.6 ±11.35 years, male to female ratio 1.2). Antibodies were checked by enzyme-linked immunosorbent assay.ResultsMean optical density levels of serum antiphosphatidylserine/prothrombin immunoglobulin G antibodies were 32.4 ±19.4, 3.6 ±2.5 and 16.1 ±15.8 absorbance units in groups 1, 2 and 3 respectively (P <0.0001), with 45.7%, 0% and 7.8% of groups 1, 2 and 3 respectively positive for the antibody (P <0.01). Mean optical density levels of serum antiphosphatidylserine/prothrombin immunoglobulin M antibodies were 14.2 ±8.7, 6.7 ±6.4 and 12.4 ±15.5 absorbance units in groups 1, 2 and 3 respectively (P <0.0001), with 7.1%, 3.4% and 9.9% of groups 1, 2 and 3 positive for the antibody. Mean optical density levels of serum antiprothrombin and antiphospholipid immunoglobulin G antibodies were higher in groups 1 and 3 compared with 2 (P <0.005) and in groups 1 and 2 compared with 3 (P <0.01), respectively. Groups 1, 2 and 3 were positive for antiphospholipid immunoglobulin G antibodies (groups 1 and 2 compared with 3) . Celiac disease sera harbor a higher antiprothrombin immunoglobulin G level compared with controls.ConclusionsIt is suggested that the intestinal injury, endothelial dysfunction, platelet abnormality and enhanced apoptosis recently described in celiac disease are at the origin of the increased exposure of phospholipids or new epitopes representing autoantigens. Those autoantibodies might play a pathogenic role in the thrombophilia associated with celiac disease and represent markers for potential anticoagulant preventive therapy.

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Section: Discussionmentioning

confidence: 99%

“…There is an increase risk of stroke in adults and children with CD [10-15]. Thrombophilia, pregnancy loss, deep vein thrombosis, small bowel infarction, atrial fibrillation, Budd-Chiari syndrome, portal and splenic vein thrombosis, and cardiovascular disease have been described [16-21].…”

Section: Introductionmentioning

confidence: 99%

The thrombophilic network of autoantibodies in celiac disease

Lerner

Agmon‐Levin

Shapira

et al. 2013

BMC Med

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“…Plus rarement, des thrombophlébites cérébrales ont été rapportées [12,13], ainsi que des localisations aux membres inférieurs [14]. Les thromboses artérielles sont exceptionnelles, représentées par de rares cas d'AVC ischémiques [15][16][17][18]. Une thrombose intracardiaque n'a jamais été rapportée à notre connaissance.…”

Section: Observationunclassified

Thrombose intracardiaque au cours d’une maladie cœliaque

Jaafoura

Atig

Bouker

et al. 2014

Journal des Maladies Vasculaires

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“…La incidencia de ictus arteriales y venosos en pacientes jóvenes con EC es baja. Se presume una patogénesis vasculítica cuando no se identifican factores protrombóticos y los valores de homocisteína son normales [89,90].…”

Section: Enfermedad Vascular Y Glutenunclassified

Neurogluten: patología neurológica por intolerancia al gluten

Hernández-Lahoz¹,

Mauri-Capdevila²,

Vega-Villar³

et al. 2011

RevNeurol

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Resumen. La intolerancia al gluten es un proceso sistémico de naturaleza autoinmune que se desarrolla, en sujetos con predisposición genética, al ingerir gluten. Aparece a cualquier edad y permanece a lo largo de toda la vida. Es más frecuente en mujeres, como ocurre con otras enfermedades autoinmunes. La enfermedad celíaca es la forma intestinal, así como la representación más importante del conjunto de patologías autoinmunes por gluten que involucran a diferentes sistemas. La afectación neurológica, con o sin enteropatía, es también frecuente y en su patogénesis intervienen el ataque inmunológico al tejido nervioso central y periférico y los cambios neurodegenerativos acompañantes. La expresión clínica es variada, pero los síndromes más comunes son la ataxia cerebelosa y la neuropatía periférica. Por último, la intolerancia al gluten se asocia, en variable proporción, a otras enfermedades complejas y podría influir en su evolución. La detección temprana de los casos de intolerancia al gluten con manifestaciones neurológicas podría proporcionar, con el tratamiento de la dieta sin gluten, un notable beneficio a los pacientes. Palabras clave. Complicaciones neurológicas. Enfermedad celíaca. Intolerancia al gluten.

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Maladie cœliaque et accidents vasculaires cérébraux ischémiques

Cited by 13 publications

References 19 publications

The thrombophilic network of autoantibodies in celiac disease

The thrombophilic network of autoantibodies in celiac disease

Thrombose intracardiaque au cours d’une maladie cœliaque

Neurogluten: patología neurológica por intolerancia al gluten

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