Malakoplakia of the Kidney

Current Concepts and Evaluation of Uro-Rectal Diseases by Transrectal Ultrasound: A Review

“…Prostate Cancer [107] Perianal Paget's Disease [108] Myxoid Liposarcoma [109] Malignant Fibrous Histiocytoma [110] Hemangiopericytoma [111] Cauda Equina Syndrome [112] Carcinoma of the Cervix [113] Carcinoma of the Vagina [114] Epidermoid Cysts [115] Prader-Willi Syndrome [116] Colorectal Carcinoma [117] Benign Prostate Hyperplasia [118] Microglandular Hyperplasia [119] Adenocarcinoma of Cervix [120] Adenoma Malignum [121] Adenosquamous Carcinoma of Cervix [122] Glassy Cell Carcinoma of Cervix [123] Adenoid Basal Carcinoma of Cervix [124] Adenomyosis [125] Uterine Fibroids [126] Endometrial Polyps [127] Hematoma [128] Fournier's Gangrene [129] Malakoplakia [130] Aneurysmal bone cyst [131] Ewing Sarcoma [132] Osteosarcoma [133] Chondrosarcoma [134] Neurofibroma [135] Neuroblastoma [136] Schwannoma [137] Chordoma [138] Malignant Schwannoma [139] Hemangioma [140] Myelolipoma [141] Leiomyoma [142] Villous Adenoma [143] Solitary Fibrous tumor [144] Castleman disease [145] Lymphoma [146] Gastrointestinal Stromal Tumor [147] Epithielial Malignancies …”

Malakoplakia of the Kidney Extending to the Descending Colon in a Patient with Secondary Adrenal Insufficiency: A Case Report

“…Most patients have associated conditions characterized by some degree of immunosuppression, as seen in solid-organ transplants, autoimmune diseases requiring steroid use, chemotherapy, chronic systemic diseases, alcohol abuse and poorly controlled diabetes 1). Despite some characteristic histological features including the presence of large histiocytes with clusters of Michaelis-Gutmann (MG) bodies, malakoplakia of the kidney is difficult to diagnose because of its rarity and varying histological pictures 2). To our knowledge, there have been no case reports of malakoplakia of the kidney in a secondary adrenal insufficiency from Korea.…”

Granulomatous Nephritis Consistent with Malakoplakia in a Cynomolgus Monkey

“…A diagnosis of malakoplakia is generally made based on the presence of large polygonal or round-shaped macrophages with foamy eosinophilic cytoplasm accompanied by MG bodies, which are believed to be associated with inadequate processing of phagocytosed bacteria 1 , 9 . However, MG bodies are found only in fully developed malakoplakia, and may be sporadic or inconspicuous in the early stages 9 , 10 .…”

“…A diagnosis of malakoplakia is generally made based on the presence of large polygonal or round-shaped macrophages with foamy eosinophilic cytoplasm accompanied by MG bodies, which are believed to be associated with inadequate processing of phagocytosed bacteria 1 , 9 . However, MG bodies are found only in fully developed malakoplakia, and may be sporadic or inconspicuous in the early stages 9 , 10 . Taken together, although the present case lacked typical MG bodies with calcium deposits, the extensive infiltration of interstitial macrophages containing PAS- and iron-positive intracytoplasmic inclusion bodies consistent with von Hansemann cells supports diagnosis of early-stage malakoplakia.…”

“…They also act as a nidus for the lamellar deposition of calcium and iron to form MG bodies. Gram-negative bacteria are often associated with malakoplakia, with E. coli found in approximately 70 to 90% of cases 9 , 13 . Because of difficulties with histological approaches including special Gram, PAS and Ziehl-Neelsen stains in detecting the microorganisms, site-specifically amplified PCR analysis is said to be useful for the determination of pathogens in malakoplakia 9 .…”