2019
DOI: 10.3390/s19143045
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Malaria-Infected Red Blood Cell Analysis through Optical and Biochemical Parameters Using the Transport of Intensity Equation and the Microscope’s Optical Properties

Abstract: The accuracy, reliability, speed and cost of the methods used for malaria diagnosis are key to the diseases’ treatment and eventual eradication. However, improvement in any one of these requirements can lead to deterioration of the rest due to their interdependence. We propose an optical method that provides fast detection of malaria-infected red blood cells (RBCs) at a lower cost. The method is based on the combination of deconvolution, topography and three-dimensional (3D) refractive index reconstruction of … Show more

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Cited by 27 publications
(11 citation statements)
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“…Hence, if RBCs are healthy, it means the flow of O 2 and CO 2 inside body is perfect. For healthy RBCs, the range of hemoglobin concentration of cell A should be between 28 g/dL and 36 g/dL, which corresponds to refractive index values between 1.402 and 1.409, respectively [28]. If someone is bitten by the female Anopheles mosquito, parasites enter into the body and reach the RBCs through the liver.…”
Section: Description Of Malaria Samples Usedmentioning
confidence: 99%
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“…Hence, if RBCs are healthy, it means the flow of O 2 and CO 2 inside body is perfect. For healthy RBCs, the range of hemoglobin concentration of cell A should be between 28 g/dL and 36 g/dL, which corresponds to refractive index values between 1.402 and 1.409, respectively [28]. If someone is bitten by the female Anopheles mosquito, parasites enter into the body and reach the RBCs through the liver.…”
Section: Description Of Malaria Samples Usedmentioning
confidence: 99%
“…Moreover, the presence of parasites into the cells also decreases both the hemoglobin concentration and refractive index value of that cell. Therefore, the presence of parasites within the various cells is ensured by the region having a low refractive index [28][29][30]. This is the first stage of malaria infection and is called the ring stage.…”
Section: Description Of Malaria Samples Usedmentioning
confidence: 99%
See 1 more Smart Citation
“…From a mechanical standpoint, these special cells (or capsules) are deformable bodies, which are immersed in a flowing fluid. Investigating the dynamics of these cells can be useful for many engineering applications such as the detection of malaria infection [10], cell sorting/separation [11], drug delivery [12], and design of devices for blood fractionation [13]. Modeling the dynamics of these special cells in fluid flow is the focus of the current work.…”
Section: Introductionmentioning
confidence: 99%
“…Later, trophozoites transform into multinucleated cells called schizonts, which are formed by the breakdown of hemoglobin and the production of hemozoin (Liu et al 2016). In the intraerythrocytic cycle, infected erythrocytes show a heterogeneous distribution of refractive index throughout the cytoplasm of the cell, while healthy erythrocytes have a homogeneous refractive index distribution (Akpa Marcel et al 2019). This significant refractive index difference between healthy and infected red blood cells can be used as an essential parameter for the diagnosis of malaria (Bendib and Bendib 2018).…”
Section: Introductionmentioning
confidence: 99%