Malaria infection during pregnancy

Prasad, Rajendra; Virk, K. J.; Sholapurkar, Shashikant L.; Mahajan, Rama

doi:10.1016/0035-9203(90)90371-k

Cited by 7 publications

(1 citation statement)

References 3 publications

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“…2.4. l 3 clearly show that parity is the relevant factor that influences susceptibility to malaria in pregnant women. The mechanisms underlying this increased susceptibility of primigravidae to malaria infection remain unclear and may involve ncjnspecific immunosuppression due to pregnancy-associated hormones such as cortisol,14 and impairment of the immune response to certain malaria antigen+ 15 An important practical implication of these results is that primigravidae are a high- Adjusted standardized MPDs FIGURE 1. Distribution of the standardized power-transformed mean parasite densities (MPDs) after adjustment for parity and area of residence, and predicted normal curves under the hypothesis of two distributions.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors of Malaria Infection during Pregnancy in Burkina Faso: Suggestion of a Genetic Influence

Cot

Abel²,

Roisin³

et al. 1993

The American Journal of Tropical Medicine and Hygiene

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A cohort of 570 untreated pregnant women from Burkina Faso was studied to assess the influence of epidemiologic factors on malaria infection, which was quantified as the mean of serial, season-adjusted parasitemia measuremects (mean parasite density [MPD]) carried out during the last five months of gestation. A significant effect of the area of maternal residence on the MPD was found ( P < 0.003) and was probably. due to geographic differences in mosquito transmission conditions. The strong relationship observed between parity and malaria infection ( P < O.OOOl), with MPD levels decreasing as the number of gestations increased, confirms that primigravidae are a high-risk group whose protection should be a priority. After adjustment for two relevant epidemiologic factors (i.e., area of residence and parity), the residual MPD values fitted a mixture of two distributions. This result supports the view that a major gene is involved in the determination of malaria infection intensities and is consistent with the results of a recent familial study in Cameroon.

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Section: Discussionmentioning

confidence: 99%