Malassezia virulence factors and their role in dermatological disorders

Kurniadi, Ivan; Wijaya, Wong Hendra; Timotius, Kris Herawan

doi:10.15570/actaapa.2022.8

Cited by 8 publications

(7 citation statements)

References 60 publications

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“…and can result in hypopigmented and hyperpigmented macules [ 258 ]. Notably, the Malassezia sp.-produced indole derivative compound malassezin can induce melanocyte apoptosis through aryl hydrocarbon receptor agonist activity [ 259 , 260 , 261 , 262 ]. This activity means malassezin was explored as a novel cosmetic treatment for facial hyperpigmentation and produces clear decreases in melanin and visible skin lightening within two to four weeks following oil–water emulsion skin treatment [ 261 , 263 ].…”

Section: Skin Microbiome Applications In Personal Care Productsmentioning

confidence: 99%

Bioprospecting the Skin Microbiome: Advances in Therapeutics and Personal Care Products

Nicholas-Haizelden,

Murphy,

Hoptroff

et al. 2023

Microorganisms

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Bioprospecting is the discovery and exploration of biological diversity found within organisms, genetic elements or produced compounds with prospective commercial or therapeutic applications. The human skin is an ecological niche which harbours a rich and compositional diversity microbiome stemming from the multifactorial interactions between the host and microbiota facilitated by exploitable effector compounds. Advances in the understanding of microbial colonisation mechanisms alongside species and strain interactions have revealed a novel chemical and biological understanding which displays applicative potential. Studies elucidating the organismal interfaces and concomitant understanding of the central processes of skin biology have begun to unravel a potential wealth of molecules which can exploited for their proposed functions. A variety of skin-microbiome-derived compounds display prospective therapeutic applications, ranging from antioncogenic agents relevant in skin cancer therapy to treatment strategies for antimicrobial-resistant bacterial and fungal infections. Considerable opportunities have emerged for the translation to personal care products, such as topical agents to mitigate various skin conditions such as acne and eczema. Adjacent compound developments have focused on cosmetic applications such as reducing skin ageing and its associated changes to skin properties and the microbiome. The skin microbiome contains a wealth of prospective compounds with therapeutic and commercial applications; however, considerable work is required for the translation of in vitro findings to relevant in vivo models to ensure translatability.

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Section: Skin Microbiome Applications In Personal Care Productsmentioning

confidence: 99%

Bioprospecting the Skin Microbiome: Advances in Therapeutics and Personal Care Products

Nicholas-Haizelden,

Murphy,

Hoptroff

et al. 2023

Microorganisms

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“…Обсуждается возможная связь повышенной колонизации кожи Malassezia spp. как таковой с воспалительными заболеваниями кишечника (неспецифический язвенный колит, болезнь Крона) [52] и другими кожными заболеваниями [53,54].…”

Section: Malassezia себорейный дерматит и коморбидные заболеванияunclassified

The pathogenesis of seborrheic dermatitis: a modern outlook

Sergeeva,

Sorokina,

Arzumanian

2023

Immunopathol Allergol Infectol

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Современные данные указывают на то, что в основе патологических изменений при себорейном дерматите различные механизмы и факторы: генетические, иммунные, экзогенные, связанные с нарушениями микробиома и течением коморбидных заболеваний. В настоящей статье представлены и обобщены новые сведения и результаты исследований, позволяющие сформировать актуальное представление о себорейном дерматите как сложном и многофакторном заболевании. Дана современная классификация клинических форм себорейного дерматита, охарактеризованы патоморфология, эпидемиология, этиология и патогенез этого заболевания, дана попытка определить роль грибков рода Malassezia в развитии патологических изменений кожи при себорейном дерматите. Описаны различные пути и механизмы развития иммунного ответа на Malassezia spp. и их метаболиты. Перечислены генетические мутации, ассоциированные с риском развития себорейного дерматита. Приведены сведения о связи себорейного дерматита с заболеваниями других органов и систем, в частности болезнью Паркинсона и прочими неврологическими патологиями, а также иммунодефицитами.

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“…тісно пов'язані з патогенезом СД [12]. А феномен трансформації шкірних коменсалів в агресивний патоген достеменно не вивчений [11].…”

Section: вступunclassified

Lipolytic activity of Malassezia spp. on inflamed seborrheic areas increases after exposure to beta-endorphin

Vysochanska¹,

Koval²

2023

Rep. of Vinnytsia Nation. Med. Univ.

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Annotation. The opiate system of the skin modulates inflammation and regeneration, while metabolic products of some bacteria and fungi disrupt the skin barrier and cause inflammation. Therefore, the study aimed to evaluate the effect of beta-endorphin (BE) on the lipolytic activity (LA) of Malassezia spp. isolated from both seborrheic areas and healthy skin of patients with seborrheic dermatitis. The study included 42 patients with moderate and severe forms of SD, with positive growth of Malassezia spp., and 17 medical workers without any skin diseases constituting the control group. Two smears were taken from the SD patients: from the face, specifically inflamed areas affected by SD, and intact skin of the sternum. Samples were transferred to MLNA (37°C; 72 h), colonies were suspended in Dixon broth, and 500 nmol/L human BE was added (3 days; 32 °C). 1 ml of the suspension was then applied to yolk agar (7 days; 35 °C). The precipitation zone was considered a sign of the presence of LA. The following statistical research methods were used: chi-square test, Mann-Whitney t-test, and Student’s test. Half of the Malassezia spp. isolated from healthy individuals did not show any LA before and after BE exposure. 69% of samples obtained from healthy areas and 95% of samples from inflamed skin areas from SD patients had LA. After BE stimulation, all samples from healthy areas of SD patients had LA. In healthy individuals, the average value of the LA did not show a significant difference after BE exposure (0.99 (0.99-1.00) vs 0.95 (0.92-0.97) p=0.358). In patients with SD, the intensity of lipolysis significantly increased. In samples obtained from healthy areas, the difference in LA was smaller than in samples from inflamed skin areas (0.06 p≤0.031; 0.22 p≤0.001). However, when comparing the intensity of LA in samples from healthy areas of SD patients and healthy individuals, no significant difference was found either before or after BE stimulation (0.91 (0.86-0.95) vs 0.95 (0.92-0.97) p=0.173). It was established that BE increases the LA of Malassezia spp., which colonizes the inflamed skin areas of patients with SD. Further research using opioid receptor blockers for the treatment of seborrheic dermatitis would be a logical next step.

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Malassezia virulence factors and their role in dermatological disorders

Cited by 8 publications

References 60 publications

Bioprospecting the Skin Microbiome: Advances in Therapeutics and Personal Care Products

Bioprospecting the Skin Microbiome: Advances in Therapeutics and Personal Care Products

The pathogenesis of seborrheic dermatitis: a modern outlook

Lipolytic activity of Malassezia spp. on inflamed seborrheic areas increases after exposure to beta-endorphin

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