Malathion exposure and insulin resistance among a group of farmers in Al-Sharkia governorate

Raafat, Nermin; Abass, Marwa; Salem, Hatem M.

doi:10.1016/j.clinbiochem.2012.07.108

Cited by 76 publications

(53 citation statements)

References 28 publications

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“…[20,26] Indeed, the previous study was demonstrated a strong correlation between the blood concentration of malathion, an organophosphate insecticide, and insulin resistance among farmers. [20,32,33] Corresponded previous studies have demonstrated increased levels of pro-inflammatory cytokines in rats exposed to organophosphates. [20,32,34,35] In addition, it has been demonstrated that the peripheral administration of interleukin-6 induces hyperglycemia and insulin resistance in humans and rodents.…”

Section: Discussionmentioning

confidence: 99%

Untitled

Sudjaroen

2017

AJP

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Background: Main of agriculturists in Singburi was cultivated rice and major pesticides' use is chlorpyrifos; however, farmers are applied bio-extracts to eliminate pest and trend to be organic farming. Hence, organic farmers may become lower risks from pesticides rather than non-organic farmers. Aim: To determine biochemical and hematological status between organic and non-organic farmers, Bang Rachan district, Singburi, Thailand. Materials and Methods: Farmers were separated into organic farmer group (N = 35) and non-organic farmer group (N = 45). Individual data for pesticide exposure were included, and pesticide-exposed relating symptoms were recorded. All demographic data of participants were documented before blood collection. Serum samples were analyzed for butyrylcholinesterase (BuChE) activity, liver function test, kidney function test, and lipid profiles. Each ethylenediaminetetraacetic acid-whole blood was determined for complete blood count (CBC). NaF plasma was analyzed for determine fasting blood glucose. All biochemical parameters were principled according to enzymatic assays and CBC was automatic analyzers. The data were represented in average ± standard deviation, and difference of biochemical and hematological status of two groups was statistically tested by unpaired t-test (P < 0.05). Results and Discussion: Blood glucose and lipid profiles of non-organic farmers were higher than reference ranges and significantly difference with other groups. Mean corpuscular hemoglobin (MCH) and MCH concentration values of non-organic farmers were lower than reference range and interpreted as anemia. Conclusions: Non-organic farmers were suchronic pesticide exposure with normal BuChE values and no related symptom; therefore, subclinical symptoms were disturbed biochemical and hematological status; and prediabetes, dyslipidemia, and anemia appeared.

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Section: Discussionmentioning

confidence: 99%

Untitled

Sudjaroen

2017

AJP

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“…Several studies have shown that OP insecticides affect glucose homeostasis in experimental animals (Abdollahi et al, 2004;Yehia et al, 2007;Celik and Suzek, 2008) and in clinical cases (Saldana et al, 2007;Montgomery et al, 2008;Raafat et al, 2012). The present study revealed that subchronic exposure to malathion was associated with concomitant increases of glycemia and insulinemia.…”

Section: Discussionmentioning

confidence: 45%

“…Acute administration of dichlorvos in rat decreased glucokinase activity in the liver and increased mRNA level (Romero-Navarro et al, 2006). Furthermore, increased activity of the liver and muscle GP has been reported after chronic ingestion of malathion in rats (Abdollahi et al, 2004;Pournourmohammadi et al, 2005) and in humans in a clinical study conducted by Raafat et al (2012). The high GP activity is associated to the increase of mRNA expression and the activating phosphorylation of this enzyme.…”

Section: Discussionmentioning

confidence: 90%

“…For instance, a study performed by Montgomery et al (2008) indicated extra incidence of diabetes among OPs applicators who worked between 1993 and 2003 in the US. Moreover, according to epidemiological reports (Rezg et al, 2010;Slotkin, 2011), clinical studies (Saldana et al, 2007;Raafat et al, 2012) and experimental data Mostafalou et al, 2012) OPs increase the risk of insulin resistance and type 2 diabetes induction.…”

Section: Introductionmentioning

confidence: 97%

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Changes in glucose metabolism and reversion of genes expression in the liver of insulin-resistant rats exposed to malathion. The protective effects of N-acetylcysteine

Lasram¹,

N²,

Lamine³

et al. 2015

General and Comparative Endocrinology

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“…The role of pollutants in diabetes and obesity was compelling in the series of papers published following this workshop (Behl et al 2013; Maull et al 2012; Taylor et al 2013; Thayer et al 2012) as well as in other reviews (Alonso-Magdalena et al 2011; Hatch et al 2010; Hectors et al 2011; Neel and Sargis 2011; Tang-Péronard et al 2011). With regard to IR in particular, several studies have investigated the potential association between pollutants and markers of insulin sensitivity (e.g., Barregard et al 2013; Chang et al 2010, 2011; Chen et al 2008; Dirinck et al 2011; Færch et al 2012; Kern et al 2004; Lee et al 2007, 2011; Nelson et al 2010; Raafat et al 2012; Wang et al 2012). The most convincing evidence for a positive association of exposure to environmental pollutants and IR is with phthalates (James-Todd et al 2012; Lind et al 2012; Stahlhut et al 2007) and air pollutants (Kelishadi et al 2009; Kim and Hong 2012).…”

Section: Introductionmentioning

confidence: 99%

Insulin Resistance and Environmental Pollutants: Experimental Evidence and Future Perspectives

Hectors

Vanparys

Gaal

et al. 2013

Environ Health Perspect

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Background: The metabolic disruptor hypothesis postulates that environmental pollutants may be risk factors for metabolic diseases. Because insulin resistance is involved in most metabolic diseases and current health care prevention programs predominantly target insulin resistance or risk factors thereof, a critical analysis of the role of pollutants in insulin resistance might be important for future management of metabolic diseases.Objectives: We aimed to critically review the available information linking pollutant exposure to insulin resistance and to open the discussion on future perspectives for metabolic disruptor identification and prioritization strategies.Methods: We searched PubMed and Web of Science for experimental studies reporting on linkages between environmental pollutants and insulin resistance and identified a total of 23 studies as the prime literature.Discussion: Recent studies specifically designed to investigate the effect of pollutants on insulin sensitivity show a potential causation of insulin resistance. Based on these studies, a summary of viable test systems and end points can be composed, allowing insight into what is missing and what is needed to create a standardized insulin resistance toxicity testing strategy.Conclusions: It is clear that current research predominantly relies on top-down identification of insulin resistance–inducing metabolic disruptors and that the development of dedicated in vitro or ex vivo screens to allow animal sparing and time- and cost-effective bottom-up screening is a major future research need.Citation: Hectors TL, Vanparys C, Van Gaal LF, Jorens PG, Covaci A, Blust R. 2013. Insulin resistance and environmental pollutants: experimental evidence and future perspectives. Environ Health Perspect 121:1273–1281; http://dx.doi.org/10.1289/ehp.1307082

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Malathion exposure and insulin resistance among a group of farmers in Al-Sharkia governorate

Cited by 76 publications

References 28 publications

Untitled

Untitled

Changes in glucose metabolism and reversion of genes expression in the liver of insulin-resistant rats exposed to malathion. The protective effects of N-acetylcysteine

Insulin Resistance and Environmental Pollutants: Experimental Evidence and Future Perspectives

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