Malathion-increased Hepatotoxicity in Diabetic Rats

Hosseini, Seyedeh Azam; Ahmadipour, Ahmad; Soltani, Motahareh; Mehdipour, Mohammad; Mandegary, Ali; Karami‐Mohajeri, Somayyeh

doi:10.18502/pbr.v6i1.3428

Cited by 2 publications

(3 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A study conducted by Hosseini et al observed similar hepatotoxic changes in their experimental animals with the use of Malathion. 21 Another study by Gupta et al reported disorganization of the normal hepatic architecture after malathion exposure. 17 While Severcan et al observed the hepatic as well as biochemical alterations in their rats after giving Malathion 100mg/kg, 200mg/kg and 400mg/kg.…”

Section: Discussionmentioning

confidence: 99%

“…12,17 Findings of the present study support this possibility as histopathological analysis of our study also observed moderate-to-severe hemorrhages, infiltration of inflammatory cells, vascular congestions, and necrosis. 17,21,22 The foremost limitation was the constraint of time and resources. Other parameters like hematological parameters, hepatic markers, and oxidative stress markers were not researched.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Histomorphometric Alterations in Hepatic Tissue from Malathion-Induced Toxicity: An Experimental Animal Study

Channar

Qazi

Almani

et al. 2021

J Islamabad Med Dental Coll

View full text Add to dashboard Cite

Background: Malathion, a widely used insecticide readily absorbed through skin and seriously affects different tissues and organs of the body. The main objective of this study was to compare the histomorphometric alterations resulting from hazardous effects of different doses of Malathion on hepatic tissue of male albino Wistar rats. Material and Methods: This animal experimental study was conducted at the Department of Anatomy and Postgraduate Research Laboratory at the Isra University, Hyderabad, Sindh Pakistan from February to July 2019. Thirty male albino Wistar rats between 250-300 grams weight were distributed equally into group A (control), group B (low-dose Malathion group; 27mg/kg 1/50 of LD50), and group C (high-dose Malathion group; 50mg/kg). Bodyweight of all rats was taken twice, before and after the experiment. The liver was dissected out, washed and weighed. Histopathological examination was done under the light microscope. Grading was done for severity in histopathological changes in each group. Data was analyzed using one-way ANOVA and Post-hoc Tukey test for comparison with the level of significance set at P-value ≤ .05. Results: Statistically significant (P < .05) decline in body weight was observed in groups B and C in comparison with group A. The relative weight of the liver was increased significantly (P < .05) in the experimental groups, when compared with the control group. Mild-to-moderate histopathological changes were observed in the low-dose Malathion group (Group B) while moderate-to-severe histopathological changes were demonstrated in the high-dose group (Group C). Conclusions: Malathion is a potent toxic pesticide and its exposure can exhibit damage to the hepatic tissues in a dose-dependent manner.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Histomorphometric Alterations in Hepatic Tissue from Malathion-Induced Toxicity: An Experimental Animal Study

Channar

Qazi

Almani

et al. 2021

J Islamabad Med Dental Coll

View full text Add to dashboard Cite

show abstract

“…Alanine aminotransferase and aspartate aminotransferase are two reliable liver indicators. This STZ induces liver toxicity in diabetic control rats due to leakage of these protein enzymes from the liver cytosol into the blood flow region 32 . EEAS restores levels of these enzymes that have been damaged by STZ.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Antioxidant, Antihyperglycemic and Hypolipidemic Potential of <i>Alstonia scholaris</i> Leaves Extracts in Streptozotocin-Induced Diabetic Rats

Mishra

Beladiya

Mehta

2023

JNR

View full text Add to dashboard Cite

The evergreen tree Alstonia scholaris (L) R. Br. (Family: Apocynaceae) is native to Australasia, southern China and the tropics of Asia. Despite its importance as a medicinal plant, little is known about its potential role in complementing standard methods of treating diabetes and its associated consequences. Therefore, the present study scientifically investigated extracts from the leaves of A. scholaris for their antioxidant (in vitro), anti-diabetic, and hypolipidemic effects in rats with type 2 diabetes mellitus. Male Wistar rats were administered streptozotocin (45 mg/kg, i.p.) and fed a high-fat diet to induce type 2 diabetes mellitus. They were treated with 400 mg/kg of an ethyl acetate (EAEAS) and ethanolic (EAAS) extract of A. scholaris leaves after complications persisted. Typical drugs were metformin (200 mg/kg) and canagliflozin (10 mg/kg). In the end, blood was drawn to determine various biochemical parameters such as fasting blood sugar, lipid profile and markers of heart, liver and kidney damage. In addition, the rat’s weight, urinary glucose concentration, urine volume, blood pressure, Electrocardiogram (ECG), and antioxidant potential of EEAS were measured. The pancreas, heart, kidneys, and liver were all subjected to histopathological analysis. A wide range of biochemical and physiological markers, including blood and urine glucose, lipid profile, markers of heart, kidney and liver damage, antioxidant levels and blood pressure, showed significant improvement in response to EEAS. Histopathology illustrates the reverse modulation in heart, kidney, and liver tissue compared to disease control. Based on the data obtained, the EAEAS achieved is far inferior to that required to treat diabetes mellitus. In summary, this present study demonstrates that EEAS (400 mg/kg) can lower blood sugar levels, fight free radicals, and lower bad cholesterol levels in rats with diabetes and complications. Further investigations can be undertaken to explore its mechanism of action at the molecular level.

show abstract

Malathion-increased Hepatotoxicity in Diabetic Rats

Cited by 2 publications

References 11 publications

Histomorphometric Alterations in Hepatic Tissue from Malathion-Induced Toxicity: An Experimental Animal Study

Histomorphometric Alterations in Hepatic Tissue from Malathion-Induced Toxicity: An Experimental Animal Study

Evaluation of the Antioxidant, Antihyperglycemic and Hypolipidemic Potential of <i>Alstonia scholaris</i> Leaves Extracts in Streptozotocin-Induced Diabetic Rats

Contact Info

Product

Resources

About