Malayalam speaking population from South India: Common five‐locus haplotypes in Malayalam speaking population

Seshasubramanian, Vani; Manisekar, N. K.; SathishKannan, Aruna Devi; Naganathan, Chandramouleeswaran; Nandakumar, Y.; Narayan, Saranya

doi:10.1111/tan.13389

Cited by 3 publications

(2 citation statements)

References 5 publications

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“…Dabigatran is a direct oral anticoagulant widely used for atrial fibrillation instead of vitamin k antagonists. Polymorphisms in CYP2C9 and ABCB1 have been associated to response to angiotensin receptor blocker losartan, since these proteins participate in the drug s metabolism and transport [85,86]. Also, variant rs1799752 in the gene coding for the Angiotensin Converting Enzyme (ACE) has been linked to the effectiveness of some ACE inhibitors, such as captopril [87] and enalapril, [88] and to spironolactone; patients with del/del genotype and chronic heart failure may have less improvement in left ventricular ejection fraction, end-systolic and end-diastolic volume [89].…”

Section: Other Drugs Used In Cardiologymentioning

confidence: 99%

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Pharmacogenetics to Avoid Adverse Drug Reactions

2022

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Gregorio Mara ñ ón. His current lines of research are related to the study of drug response and toxicity in multiple pathologies (cancer, neurology, immunology, psychiatry). He is the author of more than 90 peer-reviewed articles included in the journal citation report. Currently, Dr. L ópez-Fernández is leading studies whose objectives are to identify genetic variants associated with responses to biologic therapy in children with inflammatory bowel disease, to develop a simple and inexpensive pharmacogenetic test to be implemented in countries with limited resources, and to identify genomic biomarkers associated with opioid abuse and dual pathology.vii Preface to "Pharmacogenetics to Avoid Adverse Drug Reactions"Although a cure is the main goal of a treatment, serious adverse reactions associated with treatments are a major problem in clinical practice and cost healthcare systems a lot of money. These adverse reactions limit the success of drugs and can even lead to the death of patients. Identifying the DNA variants associated with adverse drug reactions can help to personalize medicine and sustain healthcare systems. This book focuses on the following topics: the identification of DNA variants associated with adverse drug reactions and their clinical application. It contains seven original papers and four reviews that will spread the knowledge on these critical matters. The pharmacogenetic works presented in this Special Issue can be classified into three major areas: cardiovascular, cancer, and the nervous system. This book is aimed at cardiologists, oncologists, neurologists, psychiatrists, geneticists, molecular biologists, and hospital pharmacists and other healthcare personnel.I would like to thank the staff at the Laboratory of Pharmacogenetics of the Hospital Gregorio Mara ñ ón for their support, and the patients who have participated in all the research studies shown here.

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Section: Other Drugs Used In Cardiologymentioning

confidence: 99%

“…TS, encoded by the TYMS gene, is the main target of fluoropyrimidines and low levels of expression may influence toxicity [86,87]. The two most studied SNPs in TYMS are rs2853542 (5 ′ VNTR 2R/3R) and rs11280056 (3 ′ UTR 6bp ins-del).…”

Section: Thymidylate Synthetase (Tyms)mentioning

confidence: 99%

Pharmacogenetics to Avoid Adverse Drug Reactions

2022

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Molecular analysis of HLA Class I and Class II genes in five different South Indian linguistic groups

Seshasubramanian¹,

SathishKannan²,

Naganathan³

et al. 2021

HLA

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South Indians are a heterogeneous population who speak different languages and differ in their life style and physical appearance. Major population movements, social structure and caste endogamy have influenced the genetic structure of Indian populations. The human leukocyte antigen (HLA) system of populations is highly informative because of the high level of polymorphisms. Knowledge of allele and haplotype frequencies of the HLA system is important in the search for unrelated bone marrow donors. We investigated the distribution of HLA A, B, C, DRB1 and DQB1 loci in five linguistic groups from South India. HLA–A*01:01:01~B*57:01:01:01~C*06:02:01~DRB1*07:01:01~DQB1*03:03:02 was the common haplotype with highest frequency in all the five populations studied. A few relevant haplotypes were identified as most common haplotypes in each linguistic group. Comparison of HLA‐A, ‐B and ‐DRB1 allele distribution in these five linguistic groups with the other Asian population showed that the South Indian populations were closely related to Sri Lankan populations. A large South Indian donor registry might serve as good source of donors for patients from Sri Lanka and vice versa.

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Genetic Determinants in HLA and Cytochrome P450 Genes in the Risk of Aromatic Antiepileptic-Induced Severe Cutaneous Adverse Reactions

Sukasem

Musa

Noor

et al. 2021

JPM

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Adverse drug reaction (ADR) is a pressing health problem, and one of the main reasons for treatment failure with antiepileptic drugs. This has become apparent in the event of severe cutaneous adverse reactions (SCARs), which can be life-threatening. In this review, four hypotheses were identified to describe how the immune system is triggered in the development of SCARs, which predominantly involve the human leukocyte antigen (HLA) proteins. Several genetic variations in HLA genes have been shown to be strongly associated with the susceptibility to developing SCARs when prescribed carbamazepine or phenytoin. These genetic variations were also shown to be prevalent in certain populations. Apart from the HLA genes, other genes proposed to affect the risk of SCARs are genes encoding for CYP450 drug-metabolising enzymes, which are involved in the pharmacokinetics of offending drugs. Genetic variants in CYP2C9 and CYPC19 enzymes were also suggested to modulate the risk of SCARs in some populations. This review summarizes the literature on the manifestation and aetiology of antiepileptic-induced SCARs, updates on pharmacogenetic markers associated with this reaction and the implementation of pre-emptive testing as a preventive strategy for SCARs.

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Malayalam speaking population from South India: Common five‐locus haplotypes in Malayalam speaking population

Cited by 3 publications

References 5 publications

Pharmacogenetics to Avoid Adverse Drug Reactions

Pharmacogenetics to Avoid Adverse Drug Reactions

Molecular analysis of HLA Class I and Class II genes in five different South Indian linguistic groups

Genetic Determinants in HLA and Cytochrome P450 Genes in the Risk of Aromatic Antiepileptic-Induced Severe Cutaneous Adverse Reactions

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