Male serum <i>Chlamydia trachomatis</i> IgA and IgG, but not heat shock protein 60 IgG, correlates with negatively affected semen characteristics and lower pregnancy rates in the infertile couple

Idahl, Annika; Abramsson, Leif; Kumlin, Urban; Liljeqvist, Jan‐Åke; Olofsson, Jan I.

doi:10.1111/j.1365-2605.2006.00718.x

Cited by 31 publications

(30 citation statements)

References 47 publications

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“…Leukocytospermia was twice as common in men that were positive for chlamydial DNA, but it was not always associated with the presence of chlamydial DNA in semen [81]. Also, Idahl et al showed that C. trachomatis serum IgA was significantly correlated with a higher prevalence of leukocytes in semen [63]. However, Bezold et al found no difference in prevalence of C. trachomatis and other pathogens between asymptomatic male infertile patients with and without leukocytospermia [82].…”

Section: The Controversial Role Of Leukocytospermia On Fertilitymentioning

confidence: 89%

“…By, contrast, in vivo studies of C. trachomatis in men have provided conflicting evidence as to whether it is associated with reduced fertility [62]. Idahl et al demonstrated that the presence of IgA and IgG antibodies to C. trachomatis in serum of male partners of infertile couples was significantly correlated with reduced motility of the spermatozoa, increased number of dead spermatozoa, higher prevalence of leukocytes in semen, decrease in sperm concentration, decrease in the number of progressive spermatozoa and a rise in the teratozoospermia index [63]. Veznik et al examined 627 sperm samples.…”

Section: Direct Interaction Of C Trachomatis With Sperm Function Andmentioning

confidence: 99%

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The Role of Chlamydia trachomatis in Male Infertility

et al. 2012

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Section: The Controversial Role Of Leukocytospermia On Fertilitymentioning

confidence: 89%

Section: Direct Interaction Of C Trachomatis With Sperm Function Andmentioning

confidence: 99%

The Role of Chlamydia trachomatis in Male Infertility

et al. 2012

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“…La présence de CT soit n'est pas corrélée aux paramètres classiques du sperme [10,11], soit est liée à une baisse de la concentration, de la mobilité et à une moins bonne morphologie des spermatozoïdes [12]. En présence d'anticorps anti-CT chez l'homme, il y a altération de la qualité du sperme (diminution de la concentration des spermatozoïdes) et de son pouvoir fécondant, un risque accru de stérilité tubaire chez la partenaire [13] avec plus de stérilité de couple [14,15].…”

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Le sperme « inflammatoire »: ses relations avec la fertilité

Zorn

2009

Basic Clin. Androl.

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Résumé Objectifs L’inflammation du sperme résulte d’une infection bactérienne ou virale du tractus urogénital male (TUGM); elle est souvent cliniquement silencieuse. Le dilemme existe quant aux rapports de cause à effet entre leucocytes, marqueurs de l’inflammation et mauvaise qualité du sperme. Nous nous sommes intéressés aux modifications des spermatozoïdes à l’échelon moléculaire en rapport avec l’inflammation. Matériel et méthodes Cette étude repose sur une revue de la littérature et des résultats personnels. Chez 200 hommes, partenaires de couples infertiles au spermogramme normal, nous avons étudié la condensation nucléaire et les dérivés actifs de l’oxygène (DAO) déterminés par cytométrie en flux après marquage à l’acridine orange et au dihydroéthidium en fonction des taux d’élastase du plasma séminal. Résultats Dans la littérature, on a décrit une relation positive entre infection et exacerbation de l’apoptose des spermatozoïdes avec augmentation de la nécrose et diminution du potentiel de membrane mitochondriale. Nous avons retrouvé une corrélation positive entre le taux de spermatozoïdes avec ADN dénaturé et celui d’élastase. Ce taux passait de 8,6 % à un taux d’élastase entre 0 et 100 μg/l à 15,7 % pour un taux d’élastase entre 100 et 250 μg/l, cette augmentation ne dépendant pas de la sécrétion de DAO. Le taux de spermatozoïdes avec ADN dénaturé se normalisait pour des taux d’élastase supérieurs à 600 μg/l. Discussion et conclusion Les modifications de l’ADN ou des membranes des spermatozoïdes n’influencent pas automatiquement les caractéristiques classiques du sperme ni ne réduisent la fertilité male. Elles peuvent cependant retentir négativement sur la capacitation et la réaction acrosomique, avec absence de fécondation ou mauvais développement embryonnaire. Avant de traiter, on tiendra compte du lieu et de la durée de l’inflammation ainsi que des lésions occasionnées sur les spermatozoïdes.

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“…Male and female genital tract chlamydial infections are characterized by bacterial persistence and development of post-infectious sequelae (Stephens, 2003). Moreover, data demonstrating chlamydial infection subfertility are continuously increasing (Idahl et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Innate immunity in the male genital tract: Chlamydia trachomatis induces keratinocyte-derived chemokine production in prostate, seminal vesicle and epididymis/vas deferens primary cultures

Mackern-Oberti

Maccioni

Breser

et al. 2011

Journal of Medical Microbiology

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Innate immunity in the male genital tract: Chlamydia trachomatis induces keratinocyte-derived chemokine production in prostate, seminal vesicle and epididymis/vas deferens primary cultures Chlamydia trachomatis is an intracellular pathogen that infects mucosal epithelial cells, causing persistent infections. Although chronic inflammation is a hallmark of chlamydial disease, the proinflammatory mechanisms involved are poorly understood. Little is known about how innate immunity in the male genital tract (MGT) responds to C. trachomatis. Toll-like receptors (TLRs) are a family of receptors of the innate immunity that recognize different pathogen-associated molecular patterns (PAMPs) present in bacteria, viruses, yeasts and parasites. The study of TLR expression in the MGT has been poorly investigated. The aim of this work was to investigate the keratinocyte-derived chemokine (KC) response of MGT primary cultures from C57BL/6 mice to C. trachomatis and different PAMPs. KC production by prostate, seminal vesicle and epididymis/ vas deferens cell cultures was determined by ELISA in culture supernatants. TLR2, 3, 4 and 9 agonists induced the production of KC by all MGT primary cultures assayed. In addition, we analysed the host response against C. trachomatis and Chlamydia muridarum. Chlamydial LPS (cLPS) as well as C. trachomatis and C. muridarum infection induced KC secretion by all MGT cell cultures analysed. Differences in KC levels were observed between cultures, suggesting specific sensitivity against pathogens among MGT tissues. Chemokine secretion was observed after stimulation of seminal vesicle cells with TLR agonists, cLPS and C. trachomatis. To our knowledge, this is the first report showing KC production by seminal vesicle cells after stimulation with TLR ligands, C. trachomatis or C. muridarum antigens. These results indicate that different receptors of the innate immunity are present in the MGT. Understanding specific immune responses, both innate and adaptive, against chlamydial infections, mounted in each tissue of the MGT, will be crucial to design new therapeutic approaches where innate and/or adaptive immunity would be targeted.

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Male serum Chlamydia trachomatis IgA and IgG, but not heat shock protein 60 IgG, correlates with negatively affected semen characteristics and lower pregnancy rates in the infertile couple

Abstract: Chlamydia trachomatis serum IgA in the male partner of the infertile couple has an additive value to IgG in predicting pregnancy chances, and serum IgA and IgG are associated with subtle negative changes in semen characteristics.

Cited by 31 publications

References 47 publications

The Role of Chlamydia trachomatis in Male Infertility

The Role of Chlamydia trachomatis in Male Infertility

Le sperme « inflammatoire »: ses relations avec la fertilité

Innate immunity in the male genital tract: Chlamydia trachomatis induces keratinocyte-derived chemokine production in prostate, seminal vesicle and epididymis/vas deferens primary cultures

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