Male Sex Hormone affection in patients with Tramadol dependance

Abstract

Background Tramadol is a centrally active synthetic opioid analgesic that is used extensively among Egyptian males for premature ejaculation as a self-medication. The present work conducted to outline male sex hormone affection in patients with tramadol dependence and its relation to sexual satisfaction. Results Tramadol-dependent patients have significantly lower mean serum level of testosterone compared to the control group and lower mean Sexual Satisfaction Scale than the control group. Conclusions The results provide evidence for the association between male sex hormone suppression in patients with tramadol dependence with high Addiction Severity Index of tramadol dependence.

Association between male sex hormones and tramadol abuse

“…Caju [10] found that albino rats exposed to acute and chronic morphine dosages have less Sertoli and Leydig cells. In contrast to our findings, a case-control research conducted at Assiut University Hospital in Assiut, Egypt, to investigate the effect of tramadol dependence on sex hormones found a statistically significant link between the severity of male sex hormone reduction and the duration of tramadol misuse [16].…”