Maleic Hydrazide. I. Reactions with Selected Electrophilic Reagents<sup>1</sup>

Feuer, Henry; Rubinstein, Harry

doi:10.1021/ja01554a074

Cited by 32 publications

(15 citation statements)

References 7 publications

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“…The "threshold value" for h l H (50'2 of the clieck weight) was obtained a t approximately 4 X 10-<lf. Three of the N-substitutecl c o n l~~o u~i d s (11,111,IV) were as active as M H , with "thresholtl values" between 2 X lW3 and 4 X 11f. The data for S -b e~i z o~~l -h l H coliflictetl with Graf's fintling that this compountl showed greater activity thall h l H itself (6).…”

Section: Resultsmentioning

confidence: 96%

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Relationships Between Structure and Activity of Maleic Hydrazide Analogues and Related Compounds

Parups¹,

Hoffman²,

Morley³

1962

Can. J. Biochem. Physiol.

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The growth inhibiting activities of a number of compounds structurally related to maleic hydrazide have been examined using the technique of bud growth inhibition. The degree of inhibitory activity of rnaleic hydrazide derivatives depended on the ease with which the plant call split off substituents. Straight-chain compounds which partially resemble nlaleic hydrazide were not as active as the parent compound and ring closure was necessary for full activity. Residue data for some of the tested compounds showed that activity failure was not due to lack of uptake and translocation. The analytical procedure for maleic hydrazide is shown to be valid for the quantitative determination of N-hydroxymethyl-MH and N-benzoyl-MH. lhlanuscript received April 6, 1962. Contribution Nos. 209 and 21,

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Section: Resultsmentioning

confidence: 96%

“…Several coin pounds which were not immediately available were synthesized by known methods (8,9,10,11,12). The preparation of two compounds not previous1 y described is given (me1 ting points uncorrected).…”

Section: Methodsmentioning

confidence: 99%

Relationships Between Structure and Activity of Maleic Hydrazide Analogues and Related Compounds

Parups¹,

Hoffman²,

Morley³

1962

Can. J. Biochem. Physiol.

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“…Synthesis of 1,2-bis(3-carboxyacrylyl) hydrazine 21 A cold solution of hydrazine hydrate in acetic acid was prepared by slowly adding 5.00 g (0.1 mol) of 99% hydrazine hydrate to 25 mL of cold glacial acetic acid. This was then added to a solution of 19.6 g (0.2 mol) of maleic anhydride in 100 mL of glacial acetic acid.…”

Section: Synthesis Of the Monomersmentioning

confidence: 99%

“…After this, it was dried in a vacuum for 3 h to yield 19.9 g (85%) of product, mp 183-184 C (Ref. 21; mp 183-184 C).…”

Section: Synthesis Of the Monomersmentioning

confidence: 99%

New polyamides and polyesteramides incorporated with bis(carboxy‐substituted) hydrazines: Synthesis and characterization

Kandile

Nasr

2011

J of Applied Polymer Sci

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The present article endeavors to synthesize new polyamides via direct polycondensation of various diamines [hexamethylene diamine, q-phenylene diamine, 2,5-bis(m-aminobenzylidene) cyclopentanone, and 2,6-bis (m-aminobenzylidene)cyclohexanone] with different bis (carboxy-substituted) hydrazines such as [1,2-bis(3-carboxy acrylyl)hydrazine and 1,2-bis(3-carboxybenzoyl) hydrazine]. The polycondensation reaction of 1,2-bis(3-p-hydroxyanilide acrylyl) hydrazine with the same bis(carboxysubstituted) hydrazines gave polyester amides. The polycondensation process was run in the presence of CaCl 2 , triethylphosphite, and pyridine as a catalyst. These polymers were characterized by FTIR, 1 H-NMR, solubility, TGA, DSC, X-ray, mechanical properties, and electrical conductivity. The electrical conductivity measurements showed that all new polymers show promise as insulators.

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“…Among these methods, it is necessary to mention the hydrolysis of esters of monoarylamides and sulfonylhydrazides of succinic (XIIa, XIIb), maleic (XIIIa, XIIIb), fumaric (XIVa, XIVb), and phthalic (XVa, XVb) acids (Scheme 4, R 1 = R 2 = H; X = Ar, NHSO 2 Ar; Y = OAlk) [39 -43] and cyclic imides and isoimides of dicarboxylic acids (IV -VI, X) [4,29,44,45] and dioxopyridazines (VIII) [33]. In turn, some esters of substituted amides and hydrazides of fumaric acid (XIVa, XIVb with R 1 = R 2 = H) can be readily obtained using reactions between chloroanhydrides of esters of this acid with the corresponding amines and hydrazides [39,42].…”

Section: Synthesis Of Amides and Hydrazides Of 14-dicarboxylic Acidsmentioning

confidence: 99%

Synthesis and biological activity of substituted amides and hydrazides of 1,4-dicarboxylic acids (a review)

Козьминых

2006

Pharm Chem J

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A review on the synthesis and biological activity of substituted amides, ylidenehydrazides, and acylhydrazides of 1,4-dicarboxylic (succinic, maleic, citraconic, fumaric, and phthalic) acids and their derivatives is presented. The well-known and recent data on the preparation of amides and hydrazides of dicarboxylic acids used in the synthesis of these biologically active compounds are summarized. Detailed information on the biological activity of amides and hydrazides of dicarboxylic acids and their derivatives (salts, esters, amides, and hydrazides) is provided. 8 0091-150X/06/4001-0008

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Maleic Hydrazide. I. Reactions with Selected Electrophilic Reagents¹

Cited by 32 publications

References 7 publications

Relationships Between Structure and Activity of Maleic Hydrazide Analogues and Related Compounds

Relationships Between Structure and Activity of Maleic Hydrazide Analogues and Related Compounds

New polyamides and polyesteramides incorporated with bis(carboxy‐substituted) hydrazines: Synthesis and characterization

Synthesis and biological activity of substituted amides and hydrazides of 1,4-dicarboxylic acids (a review)

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Maleic Hydrazide. I. Reactions with Selected Electrophilic Reagents1

Cited by 32 publications

References 7 publications

Relationships Between Structure and Activity of Maleic Hydrazide Analogues and Related Compounds

Relationships Between Structure and Activity of Maleic Hydrazide Analogues and Related Compounds

New polyamides and polyesteramides incorporated with bis(carboxy‐substituted) hydrazines: Synthesis and characterization

Synthesis and biological activity of substituted amides and hydrazides of 1,4-dicarboxylic acids (a review)

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Maleic Hydrazide. I. Reactions with Selected Electrophilic Reagents¹