Malignancy in Myositis

Zahr, Zaki Abou; Baer, Alan N.

doi:10.1007/s11926-011-0169-7

Cited by 145 publications

(127 citation statements)

References 40 publications

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“…Individuals with DM have a high risk of developing a malignancy. It is currently estimated that 8-60% of individuals with DM also have cancer (7). Malignancies have been identified prior to, following and in tandem with DM diagnosis and are most commonly identified one year following diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Synchronous nasopharyngeal carcinoma and cardia adenocarcinoma accompanied with suspected dermatomyositis: A case report and literature review

Ao¹,

Wang²,

Dong³

et al. 2012

Oncology Letters

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Abstract. Synchronous multiple primary cancers are relatively uncommon and synchronous multiple cancers in coexistence with dermatomyositis (DM) are extremely rare. In the present study, we report a case of a 64-year-old male with nasopharyngeal undifferentiated non-keratinizing carcinoma and cardia adenocarcinoma which were diagnosed synchronously. In addition, suspected DM was diagnosed during the course of chemotherapy. The symptoms of DM were exaggerated even when methylprednisolone while administered. The patient succumbed to nutritional deterioration four months following his initial admission. In the present study, the etiologies of multiple primary cancers are discussed and a brief review of the literature on the correlation between malignance and DM was conducted. IntroductionMultiple primary cancers are relatively uncommon. The present study reports a case in which synchronous nasopharyngeal undifferentiated non-keratinizing carcinoma and cardia adenocarcinoma were diagnosed. During the therapy course, progressive painless symmetric proximal muscle weakness and a skin rash emerged and were accompanied with dysphasia. In addition, suspected dermatomyositis (DM) was diagnosed. DM developed progressively in spite of application of methylprednisolone until the patient succumbed to nutritional deterioration on May 6, 2012. We present this case with two noteworthy aspects. Firstly, synchronous nasopharyngeal undifferentiated non-keratinizing carcinoma and cardia adenocarcinoma are relatively uncommon; and secondly the coexistance of multiple primary cancers with DM is extremely rare and indicative of poor prognosis. Case reportsClinical presentation. The patient was a 64-year-old male from Sichuan, China. Prior to admittance in January 2012, the patient had experienced tinnitus of the right ear for one year and bloody nasal mucus for two months. A tumor was identified on the right and top wall of the nasopharynx by magnetic resonance imaging (MRI) and nasopharyngeal mirror. MRI also revealed that the right pharynx was absent and the right base of the skull had been destroyed by the tumor. Pathological results of the tumor confirmed that it was nasopharyngeal undifferentiated non-keratinizing carcinoma. Two hard lymph nodes in the right neck, with an approximate diameter of 2 cm, were identified by physical examination. Comprehensive examination of the patient was performed. Abdominal computer tomography (CT) revealed multiple nodules in the liver, indicative of metastasized lesions. The diameter of these nodules ranged between 2 and 3 cm. In addition, CT revealed a thicker than normal cardia tube wall. Gastroscopy was performed and a large neoplasm was identified surrounding almost the entire diameter of the cardia (Fig. 1). Pathological analyses were consistent with the diagnosis of cardia adenocarcinoma. In situ Epstein-Barr virus (EBV)-encoded small RNA (EBER) detection demonstrated that the nasopharyngeal carcinoma cells were positive and cardia carcinoma cells were negative for EBER (Fig. 2). The study ...

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Section: Discussionmentioning

confidence: 99%

Synchronous nasopharyngeal carcinoma and cardia adenocarcinoma accompanied with suspected dermatomyositis: A case report and literature review

Ao¹,

Wang²,

Dong³

et al. 2012

Oncology Letters

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“…24,25 The incidence of neoplasms is approximately ten times greater in infl ammatory myopathies as compared to that of the general population, ranging from 3% to 12.6% in patients with DM. [26][27][28][29] The risk of cancer is greater in the three fi rst years after the diagnosis, and exists even in patients under the age of 45 years. [26][27][28][29] The most commonly affected sites are as follows: gastrointestinal; gynecologic; pulmonary; and hematologic (lymphoma).…”

Section: Discussionmentioning

confidence: 99%

“…[26][27][28][29] The risk of cancer is greater in the three fi rst years after the diagnosis, and exists even in patients under the age of 45 years. [26][27][28][29] The most commonly affected sites are as follows: gastrointestinal; gynecologic; pulmonary; and hematologic (lymphoma). [26][27][28][29][30] In this study, the prevalence of neoplasms was around 10%, and most of them were gynecologic (ovary, uterus, and breast).…”

Section: Discussionmentioning

confidence: 99%

Dermatomiosite em adulto: experiência de um centro terciário brasileiro

Souza¹,

Barros²,

Levy‐Neto³

et al. 2012

Rev. Bras. Reumatol.

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Objective: To report the results of a retrospective cohort involving 139 patients with dermatomyositis, conducted from 1991 to 2011. Methods: All patients met at least four of the fi ve Bohan and Peter criteria (1975). Results: The patients' mean age at disease onset was 41.7 ± 14.1 years, and mean disease duration was 7.2 ± 5.2 years. The sample comprised 90.2% white patients and 79.9% female patients. Constitutional symptoms occurred in less than half of the patients. Cutaneous and joint involvements occurred in 95.7% and 41.7% of the patients, respectively. Incipient pneumopathy, ground glass opacities and/or pulmonary fi brosis were present in 48.2% of the patients. All patients received prednisone (1 mg/kg/day) and 51.1% also received intravenous methylprednisolone (1 g/day for three days). Several immunosuppressants were used as corticosteroid sparing agents according to tolerance, side effects and/or refractoriness. Although disease relapse (clinical and/or laboratory) occurred in 53.2% of the patients, 76.3% were in disease remission at the end of the study. The rate of severe infection was 35.3%, and herpes zoster predominated. There were 15 (10.8%) cases of cancer, 12 within one year after the diagnosis. There were 16 deaths (11.5%), and their major causes were sepsis/septic shock (27.5%), pneumopathy attributed to the disease (31.3%), neoplasms (31.3%), and cardiovascular events (12.5%). Conclusions: In this study, the clinical and laboratory data were similar to those of other population groups described in the literature, with minimal differences regarding the frequency and characteristics of the extramuscular manifestations.

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“…In einem Review wurde 2006 über 31 bis dahin publizierte Fälle berichtet [49]. Ungewöhnlich ist auch, dass die HSP im Gegensatz zu den meisten anderen Vaskulitiden mehrheitlich (in der genannten Fallserie in 61 %) mit soliden Tumoren assoziiert ist.…”

Section: » Lymphoproliferation Imunclassified