Malignant adenolymphoma of the parotid gland: report of carcinomatous transformation

Önder, Turgut; Tiwari, R. M.; Waal, I. van der; Snow, Gordon B.

doi:10.1017/s0022215100113520

Cited by 19 publications

(5 citation statements)

References 17 publications

(3 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Central to this proposition is whether the acquisition of this genetic alteration predisposes a subset of Warthin's tumor to malignant progression. The simultaneous occurrence of Warthin's tumor and mucoepidermoid carcinoma and the development of oncocytic carcinoma in some of these lesions lend circumstantial support for this probability (Ruebner and Bramhall, 1960; Gadient and Kalfayan, 1975; Onder et al, 1990; Seifert, 1997; Nagao et al, 1998; Williamson et al, 2000; Foschini et al, 2005). However, direct evidence for a histogenetic or molecular genetic link between Warthin's tumor and the malignant transformation to mucoepidermoid and oncocytic carcinomas has yet to be established (Gadient and Kalfayan, 1975; Bullerdiek et al, 1988; Mark et al, 1989, 1990; Dahlenfors et al, 1994, 1995; Hrynchak et al, 1994; Johansson et al, 1995; El‐Naggar et al, 1996; Nagao et al, 1998; Williamson et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

CRTC1/MAML2 fusion transcript in Warthin's tumor and mucoepidermoid carcinoma: Evidence for a common genetic association

Bell

Luna

Weber

et al. 2008

Genes Chromosomes & Cancer

View full text Add to dashboard Cite

Translocations and gene fusions have an important early role in tumorigenesis. The t(11;19) translocation and its CRTC1/MAML2 fusion transcript have been identified in several examples of both Warthin's tumor and mucoepidermoid carcinoma and are believed to be associated with the development of a subset of these tumors. To determine whether Warthin's tumor and mucoepidermoid carcinoma are genetically related, we used reverse transcriptase-polymerase chain reaction and DNA sequencing to analyze microdissected components of three tumors consisting of Warthin's tumor and mucoepidermoid carcinoma. We also investigated a metastatic melanoma to Warthin's tumor and a Warthin's carcinoma of the parotid gland for comparison. The fusion transcript was identified in both Warthin's tumor and matching mucoepidermoid carcinoma components of all three tumors, in the Warthin's carcinoma, and in the Warthin's tumor component but not in the metastatic melanoma. The results provide evidence for a link between the t(11;19) fusion gene and the development of a subset of Warthin's tumors with concurrent mucoepidermoid carcinoma and possible malignant transformation to Warthin's carcinoma. This article contains Supplementary Material available at http://www.interscience.wiley.com/jpages/1045-2257/suppmat.

show abstract

Section: Introductionmentioning

confidence: 99%

CRTC1/MAML2 fusion transcript in Warthin's tumor and mucoepidermoid carcinoma: Evidence for a common genetic association

Bell

Luna

Weber

et al. 2008

Genes Chromosomes & Cancer

View full text Add to dashboard Cite

show abstract

“…Of the 32 documented cases of malignant epithelial transformation in a Warthin's tumor, 1,[3][4][5] carcinomas reported included mucoepidermoid (10 cases), 5 squamous cell (9 cases), adenocarcinoma (7 cases), undifferentiated (2 cases), anaplastic (1 case), and acinic cell (1 case). Additionally, one poorly differentiated carcinoma 3 and one poorly differentiated adenocarcinoma 6 have been previously reported. The patient with a poorly differentiated carcinoma in a Warthin's tumor underwent total parotidectomy and postoperative radiation.…”

Section: Discussionmentioning

confidence: 98%

Poorly Differentiated Carcinoma Arising in a Warthin's Tumor of the Parotid Gland: Pathogenesis, Histopathology, and Surgical Management of Malignant Warthin's Tumors

Moore

Abdel-Misih

Berne

et al. 2007

The American Surgeon™

View full text Add to dashboard Cite

show abstract

“…Squamous cell carcinoma 7–9 and mucoepidermoid carcinoma 1,6,10,11 were reported as common types of carcinoma arising within Warthin's tumor. Other types of carcinoma arising in Warthin's tumor are oncocytic carcinoma, 12 undifferentiated carcinoma 13 and adenocarcinoma not otherwise classified 14 …”

Section: Discussionmentioning

confidence: 99%

Mucoepidermoid carcinoma arising in Warthin's tumor of the parotid gland

Yamada¹,

Matsuo²,

Fujita

et al. 2002

Pathology International

View full text Add to dashboard Cite

Malignant transformation of Warthin's tumor is extremely rare, although it is the second most common benign tumor of the parotid gland. We describe our experience of mucoepidermoid carcinoma arising in Warthin's tumor of the parotid gland in a 64-year-old man. He had a swelling in the left parotid-masseteric region. The removed tumor was well encapsulated and histopathologically comprised Warthin's tumor and low-grade mucoepidermoid carcinoma. The mucoepidermoid carcinoma infiltrated lymphoid stroma of the Warthin's tumor, but capsular invasion is not found. Considering the clinical course and physical examination, the lesion was diagnosed as mucoepidermoid carcinoma arising in Warthin's tumor because its features filled the criteria of malignant transformation of Warthin's tumor. There has been no recurrence or distant metastasis for 19 months. Histological change from Warthin's tumor to mucoepidermoid carcinoma may be implicated in squamous or goblet cell metaplasia of epithelial cells. It is considered that the neoplastic cells of Warthin's tumor acquire malignant genotypes simultaneously with this dual differentiation.

show abstract

Malignant adenolymphoma of the parotid gland: report of carcinomatous transformation

Abstract: Malignant transformation of an adenolymphoma (Warthin's tumour) is a rare event. This paper presents a case of carcinoma arising in an adenolymphoma of the parotid gland.

Cited by 19 publications

References 17 publications

CRTC1/MAML2 fusion transcript in Warthin's tumor and mucoepidermoid carcinoma: Evidence for a common genetic association

CRTC1/MAML2 fusion transcript in Warthin's tumor and mucoepidermoid carcinoma: Evidence for a common genetic association

Poorly Differentiated Carcinoma Arising in a Warthin's Tumor of the Parotid Gland: Pathogenesis, Histopathology, and Surgical Management of Malignant Warthin's Tumors

Mucoepidermoid carcinoma arising in Warthin's tumor of the parotid gland

Contact Info

Product

Resources

About