Poorly Differentiated Carcinoma Arising in a Warthin's Tumor of the Parotid Gland: Pathogenesis, Histopathology, and Surgical Management of Malignant Warthin's Tumors

Moore, Forrest O.; Abdel-Misih, Rafaat Z.; Berne, John D.; Zieske, Arthur W.; Rana, Nabeel R.; Ryckman, Jon G.

doi:10.1177/000313480707300418

Cited by 11 publications

(7 citation statements)

References 10 publications

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“…Malignant progression of Warthin tumor is a rare event, as these tumors are slow growing and cystic. 1,3 Patients often present with a smooth, nontender, soft, palpable mass. Preoperative diagnosis of Warthin tumor can be made via history and physical examination along with fi ne needle aspiration cytology (FNAC).…”

Section: Introductionmentioning

confidence: 99%

Multifocal Synchronous Ipsilateral Warthin Tumors: Case Report and Review of the Literature

et al. 2010

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We report a case of a 73-year-old woman who presented with an enlarging superfi cial parotid mass, a concomitant ipsilateral deep-lobe parotid mass, and associated upper jugular lymphadenopathy. The clinical presentation and radiographic imaging were suggestive of malignancy, and the patient was treated with total parotidectomy with upper jugular lymph node sampling. Pathologic examination revealed two distinct masses, one in the superfi cial lobe and one in the deep lobe of the parotid gland, both consistent with synchronous Warthin tumors. Analysis of the upper jugular lymph nodes was consistent with reactive lymphoid hyperplasia. Although the true incidence of multicentricity in ipsilateral Warthin tumors may be underappreciated and underreported, this entity should remain in the differential diagnosis for unilateral parotid masses.

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Section: Introductionmentioning

confidence: 99%

Multifocal Synchronous Ipsilateral Warthin Tumors: Case Report and Review of the Literature

et al. 2010

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“…In 1997, Seifert described five malignancies which had arisen in WTs, and the histological criteria for malignant transformation in a WT should include a continuous transition zone from the benign double-layered oncocytic epithelium into an invasive epithelial malignancy [107]. Based on Seifert's report and subsequent published cases, the literature contains only approximately 50 carcinoma cases, squamous cell carcinoma being the most common, but mucoepidermoid carcinoma, oncocytic carcinoma, adenocarcinoma, salivary duct carcinoma, acinic cell carcinoma and undifferentiated carcinoma have also been reported [108][109][110][111][112][113]. In some of the reported cases, WTs developing into mucoepidermoid carcinomas could represent WTs with extensive mucocyte metaplasia or pure Warthin-like variants of mucoepidermoid carcinoma and thus the figure given above of 50 cases is likely too high.…”

Section: Warthin Tumour (Wt)mentioning

confidence: 99%

Analysis of the Clinical Relevance of Histological Classification of Benign Epithelial Salivary Gland Tumours

et al. 2019

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Introduction: A vast increase in knowledge of numerous aspects of malignant salivary gland tumours has emerged during the last decade and, for several reasons, this has not been the case in benign epithelial salivary gland tumours. We have performed a literature review to investigate whether an accurate histological diagnosis of the 11 different types of benign epithelial salivary gland tumours is correlated to any differences in their clinical behaviour. Methods: A search was performed for histological classifications, recurrence rates and risks for malignant transformation, treatment modalities, and prognosis of these tumours. The search was performed primarily through PubMed, Google Scholar, and all versions of WHO classifications since 1972, as well as numerous textbooks on salivary gland tumours/head and neck/pathology/oncology. A large number of archival salivary tumours were also reviewed histologically. Results: Pleomorphic adenomas carry a considerable risk (5-15%) for malignant Henrik Hellquist and Antó nio Paiva-Correia contributed to the manuscript equally and are co-first authors.

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“…Furthermore, these lesions can be unilateral, bilateral, or multifocal and may occur synchronously or metachronously with greater frequency than other benign salivary lesions [ 5 ]. Malignant transformation is exceedingly rare, but can take the form of either lymphomas or carcinomas [ 7 ]. We present a rare case of synchronous multifocal Warthin's tumor presenting as bilateral parotid lesions and cervical lymphadenopathy.…”

Section: Introductionmentioning

confidence: 99%

Multifocal Warthin’s Tumor: An Uncommon Presentation of Bilateral Cervical Lymphadenopathy

Rimmer

2018

Case Reports in Otolaryngology

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Warthin's tumor is the second most common benign lesion of the parotid gland. It is most commonly encountered in male smokers in the fifth to seventh decades of life. Uniquely, among benign lesions of the parotid gland, it can be seen bilaterally in 7–10% of cases. Very rarely, Warthin's tumor can also mimic malignant or metastatic disease by presenting within cervical lymph nodes. We present a rare case of a 71-year old male smoker with bilateral parotid lesions in addition to progressively enlarging cervical and mediastinal lymphadenopathy. Excisional biopsy of a cervical lymph node ultimately revealed Warthin's tumor.

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Poorly Differentiated Carcinoma Arising in a Warthin's Tumor of the Parotid Gland: Pathogenesis, Histopathology, and Surgical Management of Malignant Warthin's Tumors

Cited by 11 publications

References 10 publications

Multifocal Synchronous Ipsilateral Warthin Tumors: Case Report and Review of the Literature

Multifocal Synchronous Ipsilateral Warthin Tumors: Case Report and Review of the Literature

Analysis of the Clinical Relevance of Histological Classification of Benign Epithelial Salivary Gland Tumours

Multifocal Warthin’s Tumor: An Uncommon Presentation of Bilateral Cervical Lymphadenopathy

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