Malignant Astroblastoma

Sarper, Binnaz; Bayrak, Büşra Yaprak; Halis, Hatice; Alparslan, Burcu; Bayraktar, Hülya Yeni

doi:10.4274/balkanmedj.galenos.2020.2019.11.39

Cited by 2 publications

(4 citation statements)

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“…They have suggested that adjuvant chemotherapy and radiotherapy can improve the survival rate. [38] To our knowledge, astroblastoma with oligodendroglial-like cells is reported…”

Section: Discussionmentioning

confidence: 94%

“…Previous case reports showed us that astroblastoma is aggressive tumor with a tendency to recur locally after surgical resection. They have suggested that adjuvant chemotherapy and radiotherapy can improve the survival rate [38] . To our knowledge, astroblastoma with oligodendroglial-like cells is reported for the first in the literature, and the prognosis of the patient needs further follow-up.…”

Section: Discussionmentioning

confidence: 96%

“…They have suggested that adjuvant chemotherapy and radiotherapy can improve the survival rate. [ 38 ] To our knowledge, astroblastoma with oligodendroglial-like cells is reported for the first in the literature, and the prognosis of the patient needs further follow-up.…”

Section: Discussionmentioning

confidence: 99%

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Cerebral astroblastoma with oligodendroglial-like cells

Wang

2021

Medicine

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Rationale: Astroblastoma is a rare tumor of the central nervous system with uncertain biological behavior and origin. Its histopathological features have been well established, while, to our knowledge, astroblastoma with oligodendroglial-like cells have not been reported.Patient concerns: A 15-year-old girl presented with nausea, vomiting, headache, and visual disturbance.Diagnosis: Magnetic resonance imaging revealed a large neoplasm in the left temporal. Histologically, the tumor showed solid and pseudopapillary structure. Immunohistochemical staining showed that the tumor cells were positive for glial fibrillary acidic protein and vimentin. The oligodendroglial-like cells were positive for glial fibrillary acidic protein, vimentin, and oligodendrocyte transcription factor 2. The antigen KI67 labeling index was about 4%. Sequencing for isocitrate dehydrogenase (IDH) 1 codon 132 and IDH2 codon 172 gene mutations showed negative results. Furthermore, fluorescent analysis revealed neither 1p nor 19q deletion in the lesion. Based on these findings, the girl was finally diagnosed as astroblastoma.Interventions: A craniotomy with total excision of the tumor was performed.Outcomes: The follow-up time was 1 year, no evidence of disease recurrence was found in magnetic resonance imaging.Lessons: Cerebral astroblastoma with oligodendroglial-like cells is a clinically rare tumor of central nervous system. Clear distinction and diagnosis are critical. Abbreviations: EMA = epithelial membrane antigen, FISH = fluorescent in situ hybridization, GFAP = glial fibrillary acidic protein, IDH = isocitrate dehydrogenase, NeuN = neuronal nuclear antigen, Olig-2 = oligodendrocyte transcription factor 2, P53 = tumor protein 53, Syn = synaptophysin.

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“…They have suggested that adjuvant chemotherapy and radiotherapy can improve the survival rate. [38] To our knowledge, astroblastoma with oligodendroglial-like cells is reported…”

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 96%

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Cerebral astroblastoma with oligodendroglial-like cells

Wang

2021

Medicine

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“…We excluded 36 studies based on the inclusion/exclusion criteria. We identified 65 studies, including 71 patients with astroblastomas, meeting the requirements of the systematic review (Figure 2), 1–6,10,12,16–72 ranging from 2002 to 2021. In addition, we included the unpublished reports of eight patients with astroblastomas from our hospital (Table 1), resulting in a final study cohort of 79 patients.…”

Section: Resultsmentioning

confidence: 99%

Neuroimaging of astroblastomas: A case series and systematic review

Kurokawa

Baba

Kurokawa

et al. 2021

Journal of Neuroimaging

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Background and Purpose Astroblastoma is a rare type of glial tumor, histologically classified into two types with different prognoses: high and low grade. We aimed to investigate the CT and MRI findings of astroblastomas by collecting studies with analyzable neuroimaging data and extracting the imaging features useful for tumor grading. Methods We searched for reports of pathologically proven astroblastomas with analyzable neuroimaging data using PubMed, Scopus, and Embase. Sixty‐five studies with 71 patients with astroblastomas met the criteria for a systematic review. We added eight patients from our hospital, resulting in a final study cohort of 79 patients. The proportion of high‐grade tumors was compared in groups based on the morphology (typical and atypical) using Fisher's exact test. Results High‐ and low‐grade tumors were 35/71 (49.3%) and 36/71 (50.7%), respectively. There was a significant difference in the proportion of high‐grade tumors based on the tumor morphology (typical morphology: high‐grade = 33/58 [56.9%] vs. atypical morphology, 2/13 [15.4%], p = .012). The reviews of neuroimaging findings were performed using the images included in each article. The articles had missing data due to the heterogeneity of the collected studies. Conclusions Detailed neuroimaging features were clarified, including tumor location, margin status, morphology, CT attenuation, MRI signal intensity, and contrast enhancement pattern. The classification of tumor morphology may help predict the tumor's histological grade, contributing to clinical care and future oncologic research.

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Malignant Astroblastoma

Cited by 2 publications

References 4 publications

Cerebral astroblastoma with oligodendroglial-like cells

Cerebral astroblastoma with oligodendroglial-like cells

Neuroimaging of astroblastomas: A case series and systematic review

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