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Objective This study was carried out to explore the overall survival (OS) and disease-free survival (DFS) rates of patients with locally advanced head and neck cancer who were treated with chemoradiotherapy (CRT). Materials and Methods A total of 54 patients were included in our study. Among 54, 35 were treated with chemoradiotherapy and 19 were treated with radiotherapy only. The tumors were located in larynx (74%), hypopharynx (17%) and oral cavity (9%). According to TNM stage, among 54 case, one was T1, 10 were T2, 25 were T3 and 18 were T4 stage. Furthermore, 29 were N0, 11 were N1, 13 were N2 and one was N3 stage. The primary tumor was irradiated with conformal or intensity-modulated radiotherapy at an average dose of 70 Gy (64-74), and lymph nodes at a dose of 50 to 70 Gy depending on risk groups. Treatment response, OS and DFS rates were identified in 50 case. Results The follow-up period ranged from 3 months to 53 months (median=18 months). A clinically and radiologically complete response was observed in 36 (72%) of 50 patients after 2 months from completion of treatment. A partial response was detected in 12 patients (24%) and progression in 2 patients (4%). The rates of OS and DFS over the period of 3 years were found to be 51% and 58%, respectively. The most common side effect was mucositis detected in 40% of the patients. The most common side effects of systemic treatment were nausea, vomiting and leukopenia (34%). Dry mouth was found to be the most frequent late side effect. Conclusion Radical radiotherapy or chemoradiotherapy is an alternative treatment method of locally advanced head and neck tumors, with acceptable toxicity rates. Keywords Head and neck cancer; locally advanced stage; radiotherapy; chemoradiotherapy Öz Amaç Bu çalışma, kemoradyoterapi ile tedavi edilen, lokal ileri evre baş boyun kanserli hastaların genel sağkalım ve hastalıksız sağkalım oranlarını araştırmak amacıyla yapıldı.