Malignant Degeneration in Leiomyomatosis Peritonealis Disseminata

Raspagliesi, Francesco; Quattrone, Pasquale; Grosso, Giuseppe; Cobellis, Luigi; Re, E. Di

doi:10.1006/gyno.1996.0138

Cited by 59 publications

(37 citation statements)

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“…Post-operative surveillance on annual basis with imaging for at least 3 years is suggested because of reported recurrence interval of 7months to 8years. 14,15 Our patient is under follow up since two yeasr and she has remained uneventful.…”

Section: Discussionmentioning

confidence: 91%

Disseminated peritoneal leiomyomatosis: a rare entity with diagnostic conundrum

Saha¹,

Dhaliwal²,

Gainder³

et al. 2015

Int J Reprod Contracept Obstet Gynecol

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Section: Discussionmentioning

confidence: 91%

Disseminated peritoneal leiomyomatosis: a rare entity with diagnostic conundrum

Saha¹,

Dhaliwal²,

Gainder³

et al. 2015

Int J Reprod Contracept Obstet Gynecol

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“…4-6 LPD cases are generally considered benign; however, progression to malignancy has been reported. 3,7,8 Most cases of LPD are incidentally discovered, and for asymptomatic patients, there may be no need for therapy. For symptomatic patients, or those with …”

Section: Discussionmentioning

confidence: 99%

Recurrent Leiomyomatosis Peritonealis Disseminata: Sonographic and Laparoscopic Correlation

Honemeyer¹,

Ross²,

Barnard³

et al. 2012

Donald School Journal of Ultrasound in Obstetrics and Gynecology

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We present a 39-year-old G0P0 with history of infertility treatment-caused ovarian hyperstimulation and uterine fibroids, who was found to have a rare pathological presentation. Peritoneal lesions were identified during laparoscopic treatment for this patient's fibroids. Histological evaluation of these lesions revealed leiomyomatosis peritonealis disseminata (LPD), also known as disseminated peritoneal leiomyomatosis. While LPD can often be confused for metastatic leiomyosarcoma due to the histological presence of fibroblasts, myofibroblasts, smooth muscle, collagen, and spindle cell appearance, cases of LPD are generally benign, and present no need for therapy in asymptomatic cases. We present a discussion based on the clinical and sonographic presentation of LPD, its pathophysiology, treatment options and prognosis. A question set has been designed to reinforce comprehension of this presentation and associated topics for health care professionals.

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“…Radical excision of the peritoneal nodules is generally not required for most LPD cases. However, malignant transformation or concurrent leiomyosarcoma in LPD was occasionally reported in the literature [6]. Therefore, sufficient sampling and careful assessment by the pathologists are prerequisite for correct diagnosis under such rare conditions.…”

Section: Discussionmentioning

confidence: 99%