Malignant Disease of the Thyroid Gland

Carcinoma of the Thyroid Gland

“…In the present series of 63 cases of thyroid cancer, the growth arose from preexisting, clinically evident adenomas in 16 cases, or 25 per cent, an experience identical with that reported by other observers.3 18,21 YChkQ9c0utKies) Q. 2% (15) LChiC9O 17 1 %°(4)(5) ClIo/ 124.5% (5) 5V!.…”

Papillary Thyroid Carcinoma (PTC) in Children and Adults: Comparison of Initial Presentation and Long‐Term Postoperative Outcome in 4432 Patients Consecutively Treated at the Mayo Clinic During Eight Decades (1936–2015)

“…Almost 90 years ago, JJ Pemberton of the Mayo Clinic [28] commented that the ''prevailing belief'' in 1928 was that thyroid cancer was ''incurable'' and that ''surgical measures are of little avail and may even be discouraged, whenever malignant disease can be diagnosed clinically.'' Fortunately, attitudes about the surgical management of thyroid cancer have changed substantially during the ensuing years and Mayo authors, including surgeons, pathologists, endocrinologists and statisticians, have contributed regularly to this literature [5,[8][9][10][11][12][13][14][15][16].…”

Papillary Thyroid Cancer Treated at the Mayo Clinic, 1946 Through 1970: Initial Manifestations, Pathologic Findings, Therapy, and Outcome

“…Tumor Grade.-Histologic grading of thyroid cancer based on the degree of malignancy (Broders' classification) has been routinely performed at the Mayo Clinic since 1907. 53 The value of such tumor grading was established in 1937 by C. W. Mayo,54 who analyzed the 3-, 5-, and 10-year survival data of 495 patients with thyroid cancer on the basis of the histologic grade. Tumor grade was not considered in the 1961 through 1971 reports by Woolner and associates.Y":" but in a recently published Mayo study'" of invasive Hiirthle cell cancers, patients with grade 2 lesions had higher rates of both distant metastatic lesions and death from thyroid cancer than those with grade 1 lesions.…”