Malignant fibrous histiocytoma of the liver

Alberti-Flor, Juan J.; O'Hara, Michael F.; Weaver, Fred A.; Evans, J; McClure, R. Dale; Dunn, George D.

doi:10.1016/0016-5085(85)90588-8

Cited by 32 publications

(10 citation statements)

References 13 publications

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“…Ossification and dystrophic calcification are often present in cases of musculoskeletal and retroperitoneal MFH. However, these findings are never seen in hepatic MFH (25)(26)(27). Furthermore, of 16 cases with pancreatic MFH, only 1 case showed evidence of calcification (8).…”

Section: Discussionmentioning

confidence: 74%

Primary Malignant Fibrous Histiocytoma of the Pancreas: A Case with K-rasMutation and a Review of the Literature

Akatsu

Tsugita

et al. 2005

Dig Dis Sci

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Section: Discussionmentioning

confidence: 74%

Primary Malignant Fibrous Histiocytoma of the Pancreas: A Case with K-rasMutation and a Review of the Literature

Akatsu

Tsugita

et al. 2005

Dig Dis Sci

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“…3,4 It is a disease of adult patients (mean age: 57.6 years) without sex predilection (male:female ratio is 18:16). Most reported cases were solitary lesions, with tumor size ranging from 5.5 to 20 cm (average 12 cm).…”

Section: Discussionmentioning

confidence: 99%

Primary Hepatic Malignant Fibrous Histiocytoma Mimicking Hepatocellular Carcinoma: Report of Two Cases with Immunohistochemical Detection of Ezrin, and Ultrastructural and K-ras Mutation Analysis

Liew

Huang

Lin

et al. 2012

Journal of Experimental & Clinical Medicine

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“…Primary hepatic MFH is exceedingly rare, especially in comparison with MFH of other sites, or with the more common primary malignancies of the liver [2,33]. Since its original description in 1985[5], to date, only 45 cases have been described in the English literature, including recent reports by Li et al [27], Sugitani M et al [28], Kim HS et al [29], Caldeira A et al [30] and Cong Z et al [31]. Among the 45 cases, 8 cases were from China [24-26,31].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, in the English literature, a total of 45 reported cases of primary hepatic MFH were found [5-31] (Table 1). Among the 45 cases, 8 cases were from China, and the related information of 5 cases in these 8 cases was also introduced in the Chinese literature.…”

Section: Methodsmentioning

confidence: 99%

Clinical characteristics of the primary hepatic malignant fibrous histiocytoma in China: case report and review of the literature

Yao

Dai

2012

World J Surg Onc

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BackgroundA malignant fibrous histiocytoma is a soft tissue tumor that most commonly occurs in the extremities, but rarely involves the liver. The clinical characteristics and therapeutic experiences of primary hepatic malignant fibrous histiocytoma are still limited.MethodsTwo cases of primary hepatic malignant fibrous histiocytoma were analyzed retrospectively, and all the literature concerning primary hepatic malignant fibrous histiocytoma was analyzed.ResultsIn China, a total of 76 cases had been reported, among which 50 were men, with a male to female ratio of 1.9:1. Mean age of the patients was 51.0 years old, and more than 85 percent were older than 40 years. 82.9 percent (63/76) of hepatic MFH were solitary lesions, with tumor size ranging from 2.5 to 23.5 cm (average 10.3 cm). Major clinical presentation (78.4%) was abdominal pain or discomfort, accompanied with some other non-specific symptoms such as malaise, anorexia, weight loss, jaundice and fever, and small cases (14.9%) were asymptomatic. Computed tomography and ultrasound usually revealed the location of lesions. The rate of pre-operative misdiagnosis was extremely high, and 14.9 percent of patients were even misdiagnosed as a benign liver cyst, liver abscess or hematoma. Integrated resection was performed among the most cases (49/68), among which only a few ones (12 cases) were introduced to have no recurrence or metastasis or be still alive with no detail information provided, while among the cases with palliative operation or only a biopsy, the cases that were followed-up all died.ConclusionsHepatic malignant fibrous histiocytoma is a rare malignant mesenchymal tumor. The variable features of clinical presentations and images make the diagnosis difficult. Though the prognosis of primary hepatic malignant fibrous histiocytoma was rather poor, integrated resection might provide a few cases a good opportunity for surviving, suggesting that surgery might be an effective treatment.

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Malignant fibrous histiocytoma of the liver

Cited by 32 publications

References 13 publications

Primary Malignant Fibrous Histiocytoma of the Pancreas: A Case with K-rasMutation and a Review of the Literature

Primary Malignant Fibrous Histiocytoma of the Pancreas: A Case with K-rasMutation and a Review of the Literature

Primary Hepatic Malignant Fibrous Histiocytoma Mimicking Hepatocellular Carcinoma: Report of Two Cases with Immunohistochemical Detection of Ezrin, and Ultrastructural and K-ras Mutation Analysis

Clinical characteristics of the primary hepatic malignant fibrous histiocytoma in China: case report and review of the literature

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