Malignant Fibrous Histiocytoma of the Spine

Teng, Hui; Yang, Xianghong; Wei, Haifeng; Huang, Quan; Xiao, Jianru; Zhang, Chunwu

doi:10.1097/brs.0b013e318203e292

Cited by 19 publications

(4 citation statements)

References 51 publications

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“…Successful en-bloc resection of the tumor is the principal treatment and is the most important prognostic factor. 7 The role of adjuvant chemotherapy and radiation is limited and controversial. Even with en bloc resection (better results than debulking surgery in terms of survival), 8 many patients suffered from metastases to lungs, bone, liver, and skin.…”

Section: Discussionmentioning

confidence: 99%

Successful treatment of advanced malignant fibrous histiocytoma of the right forearm with apatinib: a case report

Liu

Yang

2016

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Malignant fibrous histiocytoma (MFH) is the most common soft-tissue sarcoma in late adult life. Unfortunately, advanced MFH has a poor prognosis due to a lack of effective drugs. We present here a case of advanced MFH with partial response to apatinib, a new potent oral small-molecule tyrosine kinase inhibitor targeting the intracellular domain of vascular endothelial growth factor receptor 2 (VEGFR-2). To the best of our knowledge, this is the first case report using apatinib for MFH. Quantitative polymerase chain reaction analysis revealed high expression of VEGFR-2 mRNA, suggesting that apatinib leads to clinical response by inhibiting VEGFR-2 tyrosine kinase activity and the crucial role of VEGFR-2 for MFH. Apatinib could be a new option for the treatment of MFH. Further studies are needed to optimize the treatment.

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Section: Discussionmentioning

confidence: 99%

Successful treatment of advanced malignant fibrous histiocytoma of the right forearm with apatinib: a case report

Liu

Yang

2016

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“…Patients undergoing en-bloc resection had a median survival of 26.2 months, and those with intralesional resection had a median survival of 18.6 months. Teng et al35) conducted similar research targeting the patients with MFH of the spine. Compared to the 14 months median survival in debulking surgery group, that of the en-bloc resection group was 25 months.…”

Section: Discussionmentioning

confidence: 99%

“…Two-fold increase in survival is observed between previous 30 years and recent 10 years. The reasons for the increase in survival can be summarized as follows6,11,13,19,27,33-35); 1) early detection, 2) close follow-up, and 3) development of advanced treatment modalities - en bloc resection technique, effective chemotherapeutic agents, and sophisticated radiation delivery technique. The development of advanced diagnostic techniques leads to early detection of the disease, which implies that most of patients are diagnosed without distant metastasis11,13,34).…”

Section: Discussionmentioning

confidence: 99%

Survival and Recurrence Rate after Treatment for Primary Spinal Sarcomas

Cho

Chang

2013

J Korean Neurosurg Soc

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ObjectiveWe have limited understanding on the presentation and survival of primary spinal sarcomas. The survival, recurrence rate, and related prognostic factors were investigated after treatment for primary sarcomas of the spine.MethodsRetrospective analysis of medical records and radiological data was done for 29 patients in whom treatment was performed due to primary sarcoma of the spine from 2000 to 2010. As for treatment method, non-radical operation, radiation therapy, and chemotherapy were simultaneously or sequentially combined. Overall survival (OS), progression free survival (PFS), ambulatory function, and pain status were analyzed. In addition, factors affecting survival and recurrence were analyzed : age (≤42 or ≥43), gender, tumor histologic type, lesion location (mobile spine or rigid spine), weakness at diagnosis, pain at diagnosis, ambulation at diagnosis, initial treatment, radiation therapy, kind of irradiation, surgery, chemotherapy and distant metastasis.ResultsMedian OS was 60 months, the recurrence rate was 79.3% and median PFS was 26 months. Patients with distant metastasis showed significantly shorter survival than those without metastasis. No factors were found to be significant relating to recurrence. Prognostic factor associated with walking ability was the presence of weakness at diagnosis.ConclusionPrimary spinal sarcomas are difficult to cure and show high recurrence rate. However, the development of new treatment methods is improving survival.

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“…Usually the histiocytes are located in the metaphysis or diaphysis of the long bones. MFH is aggressive with high rates of local recurrence and metastasis and the prognosis is poor, with 5–20 year survival rates of 28–33% [ 1 , 2 ]. Men are more frequently affected than women and occurrence peaks in the fifth decade [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Storiform-Pleomorphic Type of Multifocal Malignant Fibrous Histiocytoma of the Lumbar Spine

et al. 2014

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Patient: Male, 67Final Diagnosis: Malignant fibrous histiocytomaSymptoms: Back pain • leg weakness • weight lossMedication: —Clinical Procedure: —Specialty: —Objective:Rare diseaseBackground:We present the extremely rare case of a 67-year-old male with malignant fibrous histiocytoma, arising in the lumbar spine, demonstrated with radiological and pathological studies.Case Report:The patient and his relatives refused open surgical approach and we performed transpedicular vertebral corpus biopsy and vertebroplasty under spinal anesthesia. His pathological result was malignant fibrous histiocytoma. The spine is a very uncommon site for malignant fibrous histiocytoma.Conclusions:The management of malignant fibrous histiocytoma relies on the combination of maximum decompression surgery, chemotherapy and radiotherapy. Total removal is unrealistic and diagnosis is difficult. The prognosis in terms of continuing neurological deficit after surgery appears to be poor.

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Malignant Fibrous Histiocytoma of the Spine

Cited by 19 publications

References 51 publications

Successful treatment of advanced malignant fibrous histiocytoma of the right forearm with apatinib: a case report

Successful treatment of advanced malignant fibrous histiocytoma of the right forearm with apatinib: a case report

Survival and Recurrence Rate after Treatment for Primary Spinal Sarcomas

Storiform-Pleomorphic Type of Multifocal Malignant Fibrous Histiocytoma of the Lumbar Spine

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