Malignant fibrous histiocytoma of the esophagus

Naganuma, Hiroshl; Ohtani, Haruo; Sayama, Junzo; Sakai, Nobumitu; Taira, Yukio; Shibuya, Daisuke; Miyazaki, Atushi; Sakurada, H.

doi:10.1111/j.1440-1827.1996.tb03638.x

Cited by 9 publications

(4 citation statements)

References 9 publications

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“…Previous reports demonstrated that UPS tends to occur in extremities (55%), trunk (35%), retroperitoneum (9%), and left atrium (1%), thus UPSE is extremely rare [ 2 ]. The characteristics of UPSE in our case and 9 previous reports [ 5 – 13 ] are demonstrated in Table 1 . All patients were male and over 40 years of age.…”

Section: Discussionsupporting

confidence: 52%

A case of undifferentiated pleomorphic sarcoma in esophagus after multiple cancer treatments of surgery and chemoradiotherapy

et al. 2022

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Background Undifferentiated pleomorphic sarcoma (UPS) in the esophagus is extremely rare. Therefore, there are few reports of UPS in the esophagus (UPSE). We present a case of UPSE after multiple cancer treatments. Case presentation A 73-year-old man with a history of cancer treatment, including distal gastrectomy, transverse colectomy, and chemoradiotherapy, was diagnosed with an elevated lesion such as a submucosal tumor in the lower esophagus by regular endoscopy. A boring biopsy was performed, and the specimen showed features of sarcoma. The patient underwent a partial esophagectomy without lymph node dissection. Histopathological findings confirmed an undifferentiated pleomorphic sarcoma. Adjuvant therapy was not administered, and the patient survived without recurrence 1 year after surgery. Conclusions Currently, complete resection is the only treatment option for UPSE. An optimal treatment strategy using chemotherapy or radiotherapy should be established.

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Section: Discussionsupporting

confidence: 52%

A case of undifferentiated pleomorphic sarcoma in esophagus after multiple cancer treatments of surgery and chemoradiotherapy

et al. 2022

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“…Esophageal sarcomas having pleomorphic morphology such as pleomorphic leiomyosarcoma, pleomorphic rhabdomyosarcoma, and malignant fibrous histiocytoma (MFH) have been reported. 17,18 In the present case, immunoreactivity for a-SMA, which is a positive marker for pleomorphic leiomyosarcoma, was not detected in the pleomorphic tumor component. 19 Moreover, although tumor cells of MFH often demonstrate a storiform pattern histologically and myofibroblastic (a-SMA-positive) and/or histiocytic (CD68positive) differentiation immunohistochemically, none of these features was evident in the present case.…”

Section: Discussionmentioning

confidence: 41%

Section: Discussionmentioning

confidence: 47%

Esophageal pleomorphic giant cell carcinoma combined with small cell carcinoma

Yamamoto¹,

Tsuda²,

Sakano³

et al. 2007

Pathology International

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Herein is presented the case of an esophageal pleomorphic giant cell carcinoma combined with small cell carcinoma (SCC). The patient, a 77-year-old man, initially presented with dysphagia and hoarseness, and endoscopy indicated a large esophageal tumor. Despite chemoradiation therapy, the patient died from widespread local extension of the tumor and distant metastases approximately 8 months after onset of the symptoms. Histologically, the primary tumor was composed of pleomorphic tumor components, SCC components, and a tiny focus of squamous cell carcinoma. The pleomorphic tumor cells, consisting of solid sheets of poorly cohesive epithelioid cells and numerous multinucleated giant cells with abundant eosinophilic cytoplasm, were immunohistochemically positive for vimentin and desmin, with scattered positivity for epithelial membrane antigen (EMA) and neuron-specific enolase (NSE), but negative for myoglobin. These findings were histopathologically compatible with pleomorphic giant cell carcinoma occurring at other sites such as the lung. SCC cells, morphologically similar to their pulmonary counterpart, were positive for EMA and some neuroendocrine markers such as chromogranin A and NSE, and occasionally positive for vimentin and desmin. Esophageal pleomorphic giant cell carcinoma can occur in close association with SCC, and should be included in the differential diagnosis of esophageal tumors showing pleomorphism.

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“…It was fi rst reported in 1983 [3], and since then only seven cases, including our case, have been reported in the international literature (seven men; age range, 46-78 years; mean age, 60 years) [16][17][18][19][20]. Mean diameter of the tumor was 9.0 cm ( Table 1).…”

Section: Discussionmentioning

confidence: 99%

Giant tumor of malignant fibrous histiocytoma (undifferentiated pleomorphic sarcoma) in the cervical esophagus: a case report

et al. 2007

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We herein report the case of a 50-year-old man with malignant fi brous histiocytoma (MFH) of the esophagus. The patient was admitted to our hospital because of cough, dysphagia, and weight loss. Esophagography and upper gastrointestinal endoscopy revealed a giant protruding lesion in the cervical esophagus. Total esophagectomy was performed with total laryngectomy and pharyngogastrostomy. The tumor was composed of proliferating spindle cells mixed with pleomorphic giant cells. The histopathological diagnosis was malignant fi brous histiocytoma of the esophagus. Although there have been several case reports of MFH of the alimentary tract, MFH of the esophagus is extremely rare. We recently experienced a case of this disease.

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Malignant fibrous histiocytoma of the esophagus

Cited by 9 publications

References 9 publications

A case of undifferentiated pleomorphic sarcoma in esophagus after multiple cancer treatments of surgery and chemoradiotherapy

A case of undifferentiated pleomorphic sarcoma in esophagus after multiple cancer treatments of surgery and chemoradiotherapy

Esophageal pleomorphic giant cell carcinoma combined with small cell carcinoma

Giant tumor of malignant fibrous histiocytoma (undifferentiated pleomorphic sarcoma) in the cervical esophagus: a case report

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