Malignant germ cell tumors of the ovary: A study of 20 cases

Abstract

In a study of 20 patients diagnosed with malignant ovarian germ cell tumors between 1961 and 1993, clinical and pathologic findings were evaluated. Of the 20 patients, seven (35%) had dysgerminoma, two (10%) endodermal sinus tumor, three (15%) malignant teratoma, one (5%) malignant struma ovarii, one (5%) primary ovarian carcinoid, two (10%) benign teratoma with malignant transformation, and four (20%) combination germ cell tumor. Twelve patients (60%) had stage IA, five (25%) stage IC, and three (15%) stage IIIC. Twelve patients (60%) underwent conservative surgery and eight (40%) had at least bilateral salpingo-oophorectomy. At follow-up, 18 patients (90%) were alive free of disease, one (5%) had died of disease, and one (5%) had died of intercurrent disease. The actuarial 5-year survival rate was 93.3%. It is concluded that for young women who wish to preserve child-bearing capacity, regardless of the stage of the tumor, fertility-preserving surgery with complete surgical staging followed, if necessary by cisplatin-based combination chemotherapy is an appropriate and definitive treatment in the absence of involvement of the contralateral ovary and uterus. For patients in whom child-bearing capacity is not an issue, surgery should include total abdominal hysterectomy and bilateral salpingo-oophorectomy with complete staging, followed if necessary by chemotherapy.

Malignant Ovarian Germ Cell Tumours: A Survival and Prognostic Analysis

“…This has been shown to be feasible at all stages of the disease (13,14). Successful pregnancy has been reported even after treatment of bilateral ovarian dysgerminoma (15).…”

Clinicopathological Analysis of Ovarian Tumours at Birendra Military Hospital

“…It is concluded that for young women who wish to preserve child-beariung capacity, regardless of the stage of tumour, fertility preserving surgery with complete surgical staging followed, if necessary by cisplatin-based combination chemotherapy is an appropriate and defi nite treatment in the absence of involvement of the contralateral ovary and uterus. For patients in whom child -bearing capacity is not an issue, surgery should include abdominal hysterectomy and salphin go opherectomy with complete staging, followed if necessary by chemotherapy 13 . Of the non neoplastic lesions follicular cysts and corpus luteal cysts were commonest (80%) 14 .…”

Secondary Cytoreductive Surgery for Primary Yolk Sac Tumor Arising from the Omentum

“…After the Cisplatin-based combination chemotherapy regimens such as BEP have improved survival rates for germ cell tumors, including YST, 4 and recently, BEP regimens have been established as an effective treatment for YST, with complete remission and cure rates of 80%-90%. 5 The chance of complete recovery now approaches 100% for early-stage patients and at least 75% for more advanced-stage patients. 6 Three courses of BEP is the current standard postoperative adjuvant chemotherapy regimen for female patients with YST with no or small-volume residual tumor after primary surgery, and four courses of BEP is recommended in cases of bulky residual disease after surgery.…”