Malignant granular cell tumor of the breast; literature review

Gupta, Neha; Sanchety, Naveen; Verma, Pragya; Verma, G. S.

doi:10.4103/0377-4929.155330

Cited by 18 publications

(10 citation statements)

References 1 publication

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“…GCT is two times more prevalent in females than in males and commonly occurs during the fourth to sixth decades of life [ 5 ]. An overwhelming majority of GCT is benign and only 2% is malignant, usually with a poor prognosis [ 6 ]. Approximately 60% of malignant GCT patients die of metastasis within 5 years of diagnosis [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

Recurrent granular cell tumor of the thyroid: a case report and literature review

et al. 2020

BMC Surg

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Background Granular cell tumor (GCT) of the thyroid is a rare benign tumor of Schwann cell origin with a favorable prognosis and only 10 cases have been reported so far in scientific literature. The present case study describes the first case of recurrent thyroid GCT. Case presentation Our case describes a 20-year-old woman who had undergone lobectomy for GCT of the thyroid 4 years ago. Hematoxylin-eosin (HE) staining revealed that the lesion was composed of epithelioid cells with an abundance of eosinophilic granular cytoplasm. Immunohistochemical analysis showed that tumor cells tested positive for S-100 protein and negative for desmin. Both histological and immunohistochemical analyses supported the diagnosis of recurrent GCT of the thyroid. Conclusions Our case suggested that a tumor-free margin excision and post-operative follow-up are necessary for the treatment of GCT of the thyroid.

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Section: Discussionmentioning

confidence: 99%

Recurrent granular cell tumor of the thyroid: a case report and literature review

et al. 2020

BMC Surg

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“…Granular cell tumors originate from the intralobular stroma in the breast. Although almost all the lesions are benign neoplasms, malignant lesions are rarely described [9]. Malignant granular cell tumors are differentiated from benign ones with rapid growth, larger size, local recurrence rate and more frequent localization in the lower extremities.…”

Section: Discussionmentioning

confidence: 99%

Granular cell tumor presenting as an axillary mass: A case report

Çıtgez

Yiğit

Yetkin

et al. 2020

Archives of Clinical and Experimental Medicine

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Granular cell tumor (GCT) is a tumor that can arise at virtually any body site. About 5 to 15% of the cases occur in the breast, and it is relatively rare in the axilla. %1-2 of granular cell tumors are malignant. The clinical symptoms and imaging examinations of breast GCTs are non-specific and can easily be confused with malignant tumors. Most are benign and reportedly malignant cases are rare. We report a 59-year-old male with granular cell tumor in axillary region existed approximately 2 years. The palpable mass was around 15mm in diameter and felt clinically suspicious of malignancy. Tru-cut biopsy of the mass showed granular cell tumor features and surgical excision was performed. Early diagnosis and complete resection of the tumor remains the best treatment method.

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“…Tumor commonly presents in the lower extremities unlike benign granular cell tumors that occur in the head and neck and tongue. 24…”

Section: Malignant Granular Cell Tumormentioning

confidence: 99%

Soft Tissue Sarcomas: An Overview on Histomorphology

Begum¹,

K²,

Vaithy³

2019

Annals of SBV

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Background: Soft tissue sarcomas (STS) comprise a diverse group of rare malignancies that arise from connective tissues. The natural course of STS is unpredictable and aggressive if not diagnosed at an early stage. Discussion: The subclassification of these tumors is important for prognosis and clinical management of patients. In the present review, we discuss the histomorphologic features of STS and its subtypes based on 2013 World Health Organization classification and throw light on the incidence and presentation of STS. Conclusion: The systematic approach to morphologic assessment of STS outlined in this review will lead to narrowing of differential diagnoses and pave way for effective diagnosis and implementation of treatment strategies.

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Malignant granular cell tumor of the breast; literature review

Cited by 18 publications

References 1 publication

Recurrent granular cell tumor of the thyroid: a case report and literature review

Recurrent granular cell tumor of the thyroid: a case report and literature review

Granular cell tumor presenting as an axillary mass: A case report

Soft Tissue Sarcomas: An Overview on Histomorphology

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