Malignant granular cell tumour (myoblastoma) of the vulva: report of a case and review of the literature

Robertson, A J; McIntosh, W. J.; Lamont, PM; Guthrie, W.

doi:10.1111/j.1365-2559.1981.tb01768.x

Cited by 67 publications

(21 citation statements)

References 16 publications

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“…The ages of the patients ranged from 21 to 82 years (mean, 48 years). Like the benign GCTs, the malignant lesions were widely distributed, involving in addition to the skeletal soft tissue, the oral cavity [66], breast [67,68], larynx [69], esophagus [70], stomach [71], urinary bladder [72], vulva [73,74], and radial [75,76] and sciatic [77] nerves. In contrast to previous publications consisting of individual case reports, in 1998 Fanburg-Smith et al [78] reported a series of 46 cases of malignant GCT of soft tissue studied at the Armed Forces Institute of Pathology in Washington, DC.…”

Section: Clinica L Fea Turesmentioning

confidence: 99%

Granular Cell Tumor: A Review of the Pathology and Histogenesis

Ordóñez

Mackay²

1999

Ultrastructural Pathology

173

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As the name suggests, the histogenesis of the granular cell tumor is uncertain, but this intriguing neoplasm has occasioned much speculation and controversy since its description in 1926 as a myoblastoma. Though ubiquitous in its anatomic location, it is usually small, solitary, benign, and readily recognized by routine light microscopy, and questions concerning it are principally academic. However, a small number of cases are malignant and they can be difficult to identify in paraffin sections. The combined input from immunohistochemistry and electron microscopy has greatly clarified understanding of the morphology of this lesion and both methods are helpful when the differential diagnosis is a problem. The cell of origin is still undecided, and although distinct neural features argue for Schwannian origin, the noncommittal term granular cell tumor continues to be appropriate.

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Section: Clinica L Fea Turesmentioning

confidence: 99%

Granular Cell Tumor: A Review of the Pathology and Histogenesis

Ordóñez

Mackay²

1999

Ultrastructural Pathology

173

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“…Some malignancies are identical to their benign counterparts in histological findings and yet exhibit malignant potential by setting up metastases. In fact, for 3 out of 7 malignant cases reported in our review a histological diagnosis of benign GCT was made [10,22,23]. …”

Section: Discussionmentioning

confidence: 99%

Benign Granular Cell Tumor of the Vulva: First Report of Multiple Cases in a Family

Kardhashi

Deliso

Renna

et al. 2012

Gynecol Obstet Invest

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Granular cell tumors (GCTs) are uncommon soft tissue tumors of neural derivation, as supported by immunohistochemical and ultrastructural evidence. Vulvar involvement has been reported in 7–16%. This paper presents the cases of a 60-year-old woman and her 32-year-old niece with a strong family history of cancer, both presenting with an enlarging mass on their left labia majora. The lesions were treated by simple surgical excision. Histopathological examination revealed a benign vulvar GCT in both lesions. This is the first reported case of GCT of the vulva in the same family. The possible familial component of GCT needs further investigation. A systematic review of the literature on vulvar GCTs is carried out, the most complete one to date. This review unexpectedly reveals that there have been more than 130 cases of GCT of the vulva reported to date, only 7 of which were malignant. Since 5–25% of patients have multiple lesions, before planning treatment, clinicians should exclude multicentric lesions. After surgical treatment, if there is any evidence of tumor in the surgical margin, wider local excision should be performed. Regular follow-up is important for diagnosing a possible recurrence or a new lesion.

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“…A few exceptional cases of granular cell tumors have been described in which this tumor has behaved as a malignant neoplasm, with distant metastases to the lungs and other organs [29][30][31][32], Chandrasoma and Fitzgibbons [ 18] consider pancrea ticoduodenectomy too radical and advises simple drain age of the biliary tract, leaving the tumor behind. In the present case a Whipple operation was performed because of radiologic and operative suspicion of a malignant tumor.…”

Section: Discussionmentioning

confidence: 99%

Granular Cell Tumor of the Common Bile Duct

Ham¹,

Meijer²,

Ingh³

et al. 1987

Dig Surg

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A case of granular cell tumor involving the intrapancreatic common bile duct in a Caucasian woman is described. Preoperatively the tumor was diagnosed as a pancreatic or choledochal carcinoma which led to pancreaticoduodenectomy. This is the third reported case of an intrapancreatic granular cell tumor of the bile duct for which a Whipple operation was performed. 21 cases of granular cell tumor of the common bile duct reported previously are reviewed. The majority of the patients are black and female.

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Malignant granular cell tumour (myoblastoma) of the vulva: report of a case and review of the literature

Cited by 67 publications

References 16 publications

Granular Cell Tumor: A Review of the Pathology and Histogenesis

Granular Cell Tumor: A Review of the Pathology and Histogenesis

Benign Granular Cell Tumor of the Vulva: First Report of Multiple Cases in a Family

Granular Cell Tumor of the Common Bile Duct

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