Malignant Granuloma of the Face: Contribution to Its Nosology

Faria, J. Lopes de; Cutin, M; Morgante, Alberto; Ferri, R. G.

doi:10.1001/archotol.1957.03830210053008

Cited by 20 publications

(7 citation statements)

References 16 publications

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“…These observations would suggest that the neoplasms found in these cases have a functional similarity and a relationship to normal histiocytes. It is of interest that the cells in the cases of 'midline granuloma' described by de Faria et al (1957) were induced to phagocytise saccharated iron oxide in vivo, as a result of which the authors described the lesion as a reticulohistiocytoma.…”

Section: Discussionmentioning

confidence: 99%

Pathology of 'non-healing (midline) granuloma'.

Michaels¹,

Gregory²

1977

J Clin Pathol

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In a histological study of biopsy and postmortem material from 30 cases of nasal disease in which a clinical diagnosis of 'midline granuloma' or Wegener's granuloma had been given, we selected 10 cases on the basis of the presence of widespread coagulative necrosis and atypical cells. Evidence is provided that such changes represent a malignant neoplasm of histiocytic lymphoma type. Local invasion and spread to cervical and more distant lymph nodes, spleen, liver, and kidney were seen in some of the cases. Erythrophagocytic activity was marked in the spleen in three cases and histiocytic infiltration of the bone marrow in two cases, indicating a more generalised activity of histiocytic cells. Terms such as 'malignant granuloma' should be abandoned. In obstructive and ulcerating conditions of the nose efforts should be concentrated on making an accurate histological diagnosis.

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Section: Discussionmentioning

confidence: 99%

Pathology of 'non-healing (midline) granuloma'.

Michaels¹,

Gregory²

1977

J Clin Pathol

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“…In four cases (case 9, 16,17,19), the infiltrates changed from a polymorphic to a monomorphic infiltrate in subsequent biopsies. No cases showed a transition from the monomorphic to polymorphic form.…”

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confidence: 99%

“…Fresh materials were available in three cases: lymph node (case 14), subcutaneous nodule (case 17) and nasal lesion (case 19) ( out infiltration of atypical histiocytes (IC) and coagulative necrosis containing atypical cells (N). When both polymorphic and monomorphic patterns were observed in one specimen or in several specimens obtained simultaneously, the findings were expressed as follows: when a monomorphic pattern was dominant "MM/PM" and when a polymorphic pattern was dominant, "PM/MM".…”

mentioning

confidence: 99%

Biopsy findings in malignant histiocytosis presenting as lethal midline granuloma.

Aozasa¹

1982

J Clin Pathol

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Nasal biopsy findings in malignant histiocytosis presenting clinically as lethal midline granuloma are characterised by necrosis and infiltration of atypical histiocytic cells with a diffuse positive reaction for non-specific esterase. This cellular character was common to midline malignant reticulosis, and midline malignant reticulosis and malignant histiocytosis are thought to be the same disease. Patterns of histiocytic infiltration in the nasal lesions of 19 cases are reported in this paper. Polymorphic and monomorphic patterns were observed in 11 and four cases respectively, on the initial biopsy, but subsequently the infiltrates frequently became monomorphic on serial biopsy. The reverse was not observed. Surface marker and cytochemical studies showed the true histiocytic nature of the proliferating cells, and necropsy findings justified the diagnosis of malignant histiocytosis.

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“…Terracol and Camps [1954], in their review of a large number of these cases observed that a significant percent age of the patients were found to have reticulum cell sarcomas, lymphosar comas and malignant reticulosis. Richmond et al [1956] andDe Faria et al [1957] reported a small number of cases which were first diagnosed to be lethal midline granulomas, but on autopsy examination revealed wide spread malignant lymphomatous disease.…”

Section: Introductionmentioning

confidence: 99%

Non-Lethal Midline Granuloma of the Nose

Talaat

Bassiouny

Kutty

1982

ORL

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Five cases of non-lethal midline granuloma of the nose are reported. Although the histopathological picture in all cases was identical, showing pleomorphic cellular infiltration, scattered areas of necrosis and vasculitis, the clinical picture and course of the disease were completely different from lethal midline granuloma. All the patients were in good general condition and had lived for quite long periods with their lesions. The pathological process was self-limited and totally confined to the nose, sparing the plate, the lips and other facial structures. An attempt has been made in this study to review contemporary thinking on the pathology of the condition with a suggestion to improve the existing classification.

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Malignant Granuloma of the Face: Contribution to Its Nosology

Cited by 20 publications

References 16 publications

Pathology of 'non-healing (midline) granuloma'.

Pathology of 'non-healing (midline) granuloma'.

Biopsy findings in malignant histiocytosis presenting as lethal midline granuloma.

Non-Lethal Midline Granuloma of the Nose

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