Malignant Histiocytosis in 3 Cats

Kraje, Amy Clare; Patton, Clark S.; Edwards, David F.

doi:10.1892/0891-6640(2001)015<0252:mhic>2.3.co;2

Cited by 19 publications

(37 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since apparent breed predilection (Bernese mountain dogs) has been confirmed in canine HS, some hereditary factor may exist. FeLV infection are considered to be a crucial factor for the malignancy in young age [9,10]. Since the present cat was also FeLV and FIV positive, FeLV and FIV infection may play certain roles on tumorigenesis of feline histiocytic sarcoma.…”

mentioning

confidence: 76%

Histiocytic Sarcoma in the Brain of a Cat

Uchida

Tamura³

et al. 2010

J. Vet. Med. Sci.

View full text Add to dashboard Cite

ABSTRACT. A mass lesion in the subependymal region of the lateral ventricle in a 13-year-old neutered male mongrel cat with a complaint of somnolence, right circling movement and posture abnormality was examined. The magnetic resonance image examination revealed a relatively large T1-hypointense and T2-hyperintense mass lesion in the left interventricular foramen region, and there were no abnormalities in the chest and abdominal x-ray radiographic, funduscopic, and electric retinogram findings. The cat was died 43 days after the initial referral, and the post-mortem examinations revealed a poorly demarcated subependymal mass. Histologically, the brain lesion consisted of complex proliferation of highly pleomorphic cells resembling histiocytes with atypia and abundant mitotic figures. Moderate infiltrates of small reactive lymphocytes were admixed with the pleomorphic cell population. Gemistcytic astrocytes were also intermingled with the periphery of neoplastic foci. Immunohistochemically, most of the pleomorphic cells were positive for HLA-DR alphachain and ionized calcium binding adaptor molecule 1, and few were positive for lysozyme and alpha-1 antichymotrypsin. The atypical pleomorphic cells were negative for CD3, IgG (H and L), glial fibrillary acidic protein and neurofilament, suggesting monocytic/histiocytic-origin of the cells. The number of Ki-67-positive cell nuclei was extremely large, reflecting the high growth activity of these cells. Based on the findings, the lesion was considered as histiocytic sarcoma.KEY WORDS: brain, feline, histiocytic sarcoma, immunohistochemistry.J. Vet. Med. Sci. 72(1): 99-102, 2010 In dogs, histiocytic disorders have been classified into 3 major categories: canine cutaneous histiocytoma; canine reactive histiocytoses (both cutaneous and systemic); and histiocytic sarcoma complex (both localized and disseminated histiocytic sarcoma) [10]. Cats, in contrast, are rarely affected by these diseases [6]. Histiocytic sarcoma (HS) in cats has been reported to date in the intestinal wall, femur, tarsus, spleen and liver, and mediastinal and vertebral canals [1,5,11,13,16]. A brief description of an HS in the central nervous system (CNS) of a cat was reported only in a review article [19], while malignant histiocytic disorders have been well demonstrated in the canine CNS [2,4,14,18,20]. This report documents the features of a brain tumor in a cat. The histological and immunohistochemical natures characterized by the proliferation of highly pleomorphic cells resembling histiocytes and immunoreactivity for HLA-DR and ionized calcium binding adaptor molecule 1 (Iba1) are consistent with HS [7,8,15].A 13-year-old neutered male mongrel cat was presented to a private animal hospital with a complaint of somnolence, blindness, right circling movement and posture abnormality. The neurological examinations revealed a postural reaction decrease, a left mydriasis and disappearance of a physiologic nystagmus. Complete blood cell count and serum biochemical analyses were within normal ranges...

show abstract

mentioning

confidence: 76%

Histiocytic Sarcoma in the Brain of a Cat

Uchida

Tamura³

et al. 2010

J. Vet. Med. Sci.

View full text Add to dashboard Cite

show abstract

“…10,14,18,37 The cats had a low packed cell volume (19-20%), normochromic or hypochromic, regenerative or nonregenerative anemia, hypoproteinemia, hyperbilirubinemia, thrombocytopenia, and prolonged thromboplastin time. 10,14,18,37 Hepatosplenomegaly with ascites and mediastinal and pulmonary masses with hydrothorax were observed. Histologic evaluations of the tumor masses revealed a proliferation of pleomorphic histiocytes, which usually displayed marked hemophagocytosis.…”

Section: Discussionmentioning

confidence: 99%

“…The diagnosis of malignant histiocytosis was based on the morphology of the tumor cells, the hemophagocytic activity, and the variably positive immunohistochemical stains for lysozyme and Mac387 14,18,37 or positive reactions with a-1 antitrypsin, acid phosphatase, or nonspecific esterase. 10,18 These findings are most consistent with disseminated hemophagocytic histiocytic sarcomas of macrophage origin rather than histiocytic sarcomas of DC origin. One case report describes a progressive multinodular cutaneous round cell proliferation similar to the cases described in this study.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Feline Progressive Histiocytosis

2006

View full text Add to dashboard Cite

Abstract. Histiocytic proliferative diseases include reactive and neoplastic proliferations of dendritic cells (DC) or macrophages. Various forms of DC proliferations have been documented in humans and dogs; their etiology is largely unknown. With the exception of a few case reports, histiocytic proliferations have not been characterized in cats. This study summarizes clinical, morphologic, and immunophenotypic features of a feline progressive histiocytosis (FPH) in 30 cats. There was no breed or age predilection. Females were more often affected than males. Solitary or multiple nonpruritic firm papules, nodules, and plaques had a predilection for feet, legs, and face. Lesions consisted of poorly circumscribed epitheliotropic (13/30) and nonepitheliotropic (17/30) histiocytic infiltrates of the superficial and deep dermis, with variable extension into the subcutis. The histiocytic population was relatively monomorphous early in the clinical course. With disease progression, cellular pleomorphism was more frequently encountered. Histiocytes expressed CD1a, CD1c, CD18, and major histocompatibility complex class II molecules. This immunophenotype suggests a DC origin of these lesions. Coexpression of E-cadherin, a feature of cutaneous Langerhans cells, was only observed in 3 cats. FPH followed a progressive clinical course; the lesions, however, were limited to the skin for an extended period of time. Terminal involvement of internal organs was documented in 7 cases. Treatment with chemotherapeutics or immunosuppressive and immunomodulatory drugs was not successful. The etiology of FPH remains unknown. FPH is best considered an initially indolent cutaneous neoplasm, which is mostly slowly progressive and may spread beyond the skin in the terminal stage.

show abstract

“…The majority of these tumors in cats were disseminated and involved organs such as skin, liver, spleen, lymph nodes, and bone marrow with anemia and thrombocytopenia as common hematologic findings. 9 Histiocytic sarcoma (HS) as a solitary tumor has been rarely described in cats and reports to date include an intramural intestinal mass, a femoral mass, and a mediastinal and vertebral canal HS that resulted in a secondary myelopathy. 2,10,11 A brief description of an HS of the central nervous system of a cat was also included in a review article of intraoperative tumor diagnosis in dogs and cats, but without much clinical detail.…”

mentioning

confidence: 99%

Histiocytic Sarcoma in the Tarsus of a Cat

Pinard¹,

Wagg²,

Girard³

et al. 2006

Vet Pathol

View full text Add to dashboard Cite

Abstract.A 12-year-old Persian cat was examined for a firm swelling of the right tarsal region and enlargement of the corresponding right popliteal lymph node. Cytologic evaluation demonstrated a population of malignant cells consistent with large cell lymphoma. Necropsy revealed a multilobulated subcutaneous mass involving the tarsus with some extension into adjacent deep muscular tissue. Histologically, the mass was composed of round cells with eosinophilic cytoplasm and pleomorphic anisokaryotic nuclei. Evidence of articular and nodal infiltration by these cells was observed. Differential diagnoses included synovial sarcoma and histiocytic sarcoma. Neoplastic cells were negative for cytokeratin, CD79a, and CD3 and positive for CD18, vimentin, lysozyme, and alpha-1-antitrypsin, most consistent with a diagnosis of histiocytic sarcoma. This is the first report of a histiocytic sarcoma involving a joint of a cat. The final diagnosis was based on the light microscopic appearance in combination with the immunohistochemical stains.

show abstract

Malignant Histiocytosis in 3 Cats

Cited by 19 publications

References 0 publications

Histiocytic Sarcoma in the Brain of a Cat

Histiocytic Sarcoma in the Brain of a Cat

Feline Progressive Histiocytosis

Histiocytic Sarcoma in the Tarsus of a Cat

Contact Info

Product

Resources

About