Malignant Hyperthermia: Biochemical Aspects of the Acute Episode

Heffron, J. J. A.

doi:10.1093/bja/60.3.274

Cited by 39 publications

(11 citation statements)

References 16 publications

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“…Malignant hyperthermia has been previously associated with hyperglycaemia. Several works regarding hepatic metabolism during porcine malignant hyperthermia have shown a large release of glucose and potassium from the liver [45,46]. The hypoglycaemia detected in our study may have been due to severe acute hepatotoxicity induced by MDMA, suggesting that the liver could be more sensitive to MDMA at higher temperatures.…”

Section: Physiological Changessupporting

confidence: 46%

Effects of MDMA on blood glucose levels and brain glucose metabolism

Soto-Montenegro

Vaquero

Arango

et al. 2007

Eur J Nucl Med Mol Imaging

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Purpose This study was designed to assess changes in glucose metabolism in rats administered single or repeated doses of MDMA. Methods Two different experiments were performed: (1) A single-dose study with four groups receiving 20 mg/kg, 40 mg/kg, saline or heat, and (2) a repeated-dose study with two groups receiving three doses, at intervals of 2 h, of 5 mg/kg or saline. Rats were imaged using a dedicated small-animal PET scanner 1 h after single-dose administration or 7 days after repeated doses. Glucose metabolism was measured in 12 cerebral regions of interest. Rectal temperature and blood glucose were monitored. Results Peak body temperature was reached 1 h after MDMA administration. Blood glucose levels decreased significantly after MDMA administration. In the single-dose experiment, brain glucose metabolism showed hyperactivation in cerebellum and hypo-activation in the hippocampus, amygdala and auditory cortex. In the repeated-dose experiment, brain glucose metabolism did not show any significant change at day 7.Conclusion These results are the first to indicate that MDMA has the potential to produce significant hypoglycaemia. In addition, they show that MDMA alters glucose metabolism in components of the motor, limbic and somatosensory systems acutely but not on a long-term basis.

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Section: Physiological Changessupporting

confidence: 46%

Effects of MDMA on blood glucose levels and brain glucose metabolism

Soto-Montenegro

Vaquero

Arango

et al. 2007

Eur J Nucl Med Mol Imaging

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“…As ATP is exhausted the loss of the integrity of the mitochondrial and cellular membranes occur. With cell membrane disintegration increased amounts of electrolytes and myoglobin are released from the cell to the extracellular fluid (Heffron, 1988).…”

Section: Problem Statement and Purposementioning

confidence: 99%

“…Because the myocardium is composed of cardiac smooth muscle its calcium regulation is not affected. However, metabolic acidosis and increased levels of potassium can lead to dysrhythmias, declining cardiac contractility, and eventual cardiac MH Preparedness 6 arrest (Heffron, 1988). …”

Section: Problem Statement and Purposementioning

confidence: 99%

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Malignant Hyperthermia Preparation in the United States Air Force

Williams¹

1999

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“…For instance, it is well-known that myoglobin, which has a low molecular weight ( ca . 16,000 Da), leaks into the circulation, resulting in myoglobinemia [13]. …”

Section: Introductionmentioning

confidence: 99%

Associations of biochemical changes and maternal traits with mutation 1843 (C>T) in the RYR1 gene as a common cause for porcine stress syndrome

Popovski

Tanaskovska

Miskoska-Milevska

et al. 2016

Balkan Journal of Medical Genetics

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Stress syndrome is usually caused by a mutation in the ryanodine receptor gene (ryr1) and it is widely studied in humans and swine populations. The protein product of this gene plays a crucial role in the regulation of calcium transport in muscle cells. A G>T mutation in the human ryr1 gene, which results in the replacement of a conserved arginine at position 614 where a leucine occurs at the same position as the previously identified Arg→Cys mutation reported in all cases of porcine stress syndrome (PSS). Porcine stress syndrome affects biochemical pathways in stress-susceptible individuals during a stress episode and some biochemical parameters that were used as markers for diagnostic purposes. Also, PSS has remarkable influence on the maternal characteristics of sows. This study dealt with different genotypes for PSS and its association with possible biochemical changes and maternal traits of sows. Seventy-three reproductive sows genotyped for PSS by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) were included in this survey. Sixty of them were stress-free (NN), 11 were heterozygous carriers (Nn) and two animals were homozygous (nn) for the 1843 (C>T) mutation. Significant differences in non stress induced animals with different PSS genotypes were found in the values of creatine phoshokinase (CPK), lactate dehydrogenase (LDH), alkaline phosphatase (AP) and aspartate aminotransferase (AST). Regarding the maternal traits, our study showed that stress susceptible animals (nn) have an increased number of stillborn piglets and a reduced number of newborn piglets compared with heterozygous and normal animals.

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Malignant Hyperthermia: Biochemical Aspects of the Acute Episode

Cited by 39 publications

References 16 publications

Effects of MDMA on blood glucose levels and brain glucose metabolism

Effects of MDMA on blood glucose levels and brain glucose metabolism

Malignant Hyperthermia Preparation in the United States Air Force

Associations of biochemical changes and maternal traits with mutation 1843 (C>T) in the RYR1 gene as a common cause for porcine stress syndrome

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