Malignant Hyperthermia Induction in Susceptible Swine Following Exposure to Arduan

Williams, Charles H.; Farias, Maria do Socorro Quintino; Marvasti, Mehdi A.; Knight, Alfred B.; Ekery, D; Daly, Ira W.; Zayed, I.

doi:10.1213/00000539-199002001-00433

Cited by 68 publications

(5 citation statements)

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“…These onset times compare very favorably with 67.5 sec in control pigs and 72.86 sec in MHS pigs for pipecurium (Arduan R ) [11]. Onset time was 120 sec in Tibialis and 174 sec in Soleus muscles of the anesthetized cat [2].…”

Section: Discussionsupporting

confidence: 55%

“…This compares favorably with 8.5 min for atracurium in pigs [11], 12.0 min for vecuronium in pigs [7], 4.36 min for pipecurium (Arduan R ) in pigs, and 2.9 min for Tibialis and 5.2 min for Soleus muscles in the anesthetized cat [2]. The recovery rate was 2.1 min in rats and 5.3 min in guinea pigs.…”

Section: Discussionmentioning

confidence: 54%

“…Duration 90 was 10.5 min in control pigs and 8.93 min in MHS pigs used in the pipecurium (Arduan R ) experiments [11]. Clinical duration was 6 min in rats and 15.8 min in guinea pigs [3].…”

Section: Discussionmentioning

confidence: 96%

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Malignant Hyperthermia: Evaluation of “<i>Organon</i>” 9426 in Malignant Hyperthermia Susceptible Pigs

Williams¹

2015

OJMIP

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Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 54%

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Malignant Hyperthermia: Evaluation of “<i>Organon</i>” 9426 in Malignant Hyperthermia Susceptible Pigs

Williams¹

2015

OJMIP

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“…Succinylcholine and possibly tubocurarine 94 and gallamine may trigger malignant hyperthermia. Pancuronium, atracurium, vecuronium, doxacurium, 95 mivacurium, 95 and rocuronium 96 are less likely to have such an effect.…”

Section: Patients With Neuromuscular Disordersmentioning

confidence: 98%

New Neuromuscular Blocking Drugs

Hunter

1995

N Engl J Med

146

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The new nondepolarizing neuromuscular blocking drugs have specific advantages over succinylcholine. Rocuronium has an onset of action that is almost as rapid as that of succinylcholine and may be useful in patients with residual gastric contents. This drug may replace vecuronium, since the two agents are otherwise similar. The onset of action of mivacurium is similar to that of atracurium, but recovery from the blockade is more rapid (if the plasma cholinesterase level is normal), making mivacurium useful for short procedures. Although pipecuronium and doxacurium have minimal effects on the cardiovascular system, their long and variable onset and duration of action limit their usefulness. The need for either drug is questionable. There is still a need, however, for a nondepolarizing drug that has an onset of action as rapid as that of succinylcholine but a duration of action similar to that of mivacurium, with no adverse cardiovascular effects and clearance from the body that is independent of organ function.

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“…Nor did a clinical dose of Atracurium protect the MHS pigs from a triggering dose of Halothane. Organon 9426 (Rocuronium), another non-depolarizing muscle relaxant, did not trigger MH in MHS pigs [15], but did have the unusual property of completely blocking the development of MH in MHS pigs from use of Halothane at a clinical dosage level [15].…”

Section: Incidence Of Mh Cases In Kc Was One Case Per 597 240mentioning

confidence: 99%

A Review of the Factors Affecting the Incidence of Malignant Hyperthermia in the Greater Kansas City Area

Williams¹,

Hoech²,

Zukaitis³

2014

ABB

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Malignant Hyperthermia (MH) is a rare genetic disease. However, it is devastating when it occurs in a patient. MH is usually triggered by inhalational anesthetics and/or depolarizing muscle relaxants. Public awareness of MH has increased with the presentation of an episode on the television program, "House", and the availability of web-based information. For over 20 years, the MH susceptible pig has been used in experiments by our group as an animal model for MH in humans. . During the past ten years (1996-2006), there were only 2 cases of MH, representing an incidence rate of 1:597,240. That decrease is an 11.13 fold (or 89%) decrease which is very significant. Despite the reduced incidence of Malignant Hyperthermia, two recent cases of MH that result in deaths in Wisconsin and Florida make it imperative that MH is recognized early and appropriate treatment initiated without delay. We have expanded our analysis of the futile cycle mechanism that underlies the MH syndrome. MH is equivalent to the rapid discharge of a battery by a short circuit. The incidence of Malignant Hyperthermia in the Greater

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Malignant Hyperthermia Induction in Susceptible Swine Following Exposure to Arduan

Cited by 68 publications

References 0 publications

Malignant Hyperthermia: Evaluation of “<i>Organon</i>” 9426 in Malignant Hyperthermia Susceptible Pigs

Malignant Hyperthermia: Evaluation of “<i>Organon</i>” 9426 in Malignant Hyperthermia Susceptible Pigs

New Neuromuscular Blocking Drugs

A Review of the Factors Affecting the Incidence of Malignant Hyperthermia in the Greater Kansas City Area

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Malignant Hyperthermia Induction in Susceptible Swine Following Exposure to Arduan

Cited by 68 publications

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Malignant Hyperthermia: Evaluation of “&lt;i&gt;Organon&lt;/i&gt;” 9426 in Malignant Hyperthermia Susceptible Pigs

Malignant Hyperthermia: Evaluation of “&lt;i&gt;Organon&lt;/i&gt;” 9426 in Malignant Hyperthermia Susceptible Pigs

New Neuromuscular Blocking Drugs

A Review of the Factors Affecting the Incidence of Malignant Hyperthermia in the Greater Kansas City Area

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About

Malignant Hyperthermia: Evaluation of “<i>Organon</i>” 9426 in Malignant Hyperthermia Susceptible Pigs

Malignant Hyperthermia: Evaluation of “<i>Organon</i>” 9426 in Malignant Hyperthermia Susceptible Pigs