Malignant lymphoma in Eastern India: A retrospective analysis of 455 cases according to World Health Organisation classification

Mondal, Santosh Kumar; Mandal, Palash; Roy, Saptarshi Dutta; Chattopadhyay, Subrata; Roy, Sayak; Biswas, Pranab Kumar

doi:10.4103/0973-1482.136639

Cited by 13 publications

(34 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Extranodal marginal zone B-Cell Lymphomas (MALT) which accounted for 3 cases (8.57%) and Nodal marginal zone B-Cell Lymphoma which accounted for 2 cases (5.71%). These findings were similar with the findings of mandel et al & Roy et al [12,18] Among the T-cell lymphomas, anaplastic large cell lymphoma (ALCL) was the most common subtype forming 5 cases (41.67%) of all NHL. T-cell lymphoblastic lymphoma accounted for 3cases (25%), peripheral T-cell lymphomas (NOS) accounted for 3 cases (25%) and Angioimmunoblastic lymphoma accounted for 1 case (8.33%) of all NHL cases respectively.…”

Section: Discussionsupporting

confidence: 82%

See 1 more Smart Citation

Spectrum of Malignant Lymphoma in a Tertiary Care Hospital of North Eastern India

Borgohain

Gogoi

Sharma

et al. 2018

APALM

View full text Add to dashboard Cite

Background:The term malignant Lymphomas embrace a variable group of Proliferative diseases that originate in the Lymph node or extra nodal Lymphatic Tissue. It constitutes 3.69% of all Malignancies World Wide. The incidence of Lymphoma exhibits a marked Geographic variation in the World. Methods:The study included58 patients who were histologically diagnosed as Malignant lymphomas in our hospital, the paraffin embedded blocks of these cases were evaluated by a panel of immunohistochemistry markers by taking proper controls and using the standard protocol. Statistical analysis were performed by SPSS software.Results: Out of the 58 cases of Malignant Lymphoma 47 were diagnosed as Non Hodgkins Lymphoma and 11 cases (19%) as Hodgkins Lymphoma. Of these 58 cases of Malignant Lymphoma, adults were 51 and paediatric cases were 7, male female ratio was 2.6:1 and Non Hodgkins Lymphoma was Commoner. B cell Lymphomas were the predominant type accounts for 74.5% of all Non Hodgkins Lymphoma cases of these B cell Lymphomas Diffuse large B cell Lymphoma was the Predominant type.Among the T cell Lymphomas Anaplastic large cell Lymphoma was the commonest subtype. Nodular Sclerosis Cases were seen most commonly in the Hodgkins Category. Extra nodal Lymphomas were also seen in 35.6% cases with Tonsil being the commonest site. Conclusion:Non Hodgkins Lymphoma was significantly more common in this region and diffuse large B cell Lymphoma was the predominant type. A combination of Histopathology and a Meticulous Immunohistochemistry helps in properly solving the diagnostic challenges.

show abstract

Section: Discussionsupporting

confidence: 82%

“…Our study showed 81% of Non Hodgkins Lymphoma and 19% of Hodgkins Lymphoma which was similar to the findings of (Manoj et al & mandal et al) 76.3% and 23.7% respectively. [11,12] . The incidence of Hodgkins lymphoma was more lower in some Asian countries like Japan (7%), Thailand (8.5%) and china (6.6%).…”

Section: Discussionmentioning

confidence: 99%

Spectrum of Malignant Lymphoma in a Tertiary Care Hospital of North Eastern India

Borgohain

Gogoi

Sharma

et al. 2018

APALM

View full text Add to dashboard Cite

show abstract

“…A review of other published studies from NAF/ME/IN (Castella et al , ; Almasri et al , ; Isikdogan et al , ; Abdel‐Fattah & Yassine, ; Sahni & Desai, ; Akhtar et al , ; Goldman et al , ; Ameen et al , ; Mozaheb et al , ; Yaqo et al , ; Arora et al , ; Otrock et al , ; Mondal et al , ) generally showed relative frequencies of NHL subtypes similar to our study (Table ). The most common lymphoma in all of these studies was DLBCL, ranging from 31% in Egypt (Abdel‐Fattah & Yassine, ) to 59% in the United Arab Emirates (UAE) (Castella et al , ), with most studies reporting a frequency above 40%.…”

Section: Discussionmentioning

confidence: 87%

“…A particularly high frequency of T‐LBL was observed in India (7·2%), significantly higher than in NA (2%). Studies from other countries in the region (Table ) have shown variable relative frequencies of T‐LBL ranging from 0·8% to 8·6% (Castella et al , ; Almasri et al , ; Isikdogan et al , ; Sahni & Desai, ; Goldman et al , ; Ameen et al , ; Yaqo et al , ; Arora et al , ; Mondal et al , ). Interestingly, two other studies from India also reported high relative frequencies of T‐LBL, of 6·9% (Sahni & Desai, ) and 8·6% (Mondal et al , ), whereas another study reported a frequency of 2·2% (Arora et al , ).…”

Section: Discussionmentioning

confidence: 99%

“…The epidemiological risk factors contributing to these variations are unclear, but are probably a combination of genetic, cultural and lifestyle factors, as well socioeconomic, resource and environmental factors that are specific for each region (Chiu & Weisenburger, ; Morton et al , ; Evens & Chiu, ). A number of small studies conducted in North Africa, the Middle East and India (NAF/ME/IN) have reported on the relative frequencies of NHL subtypes in various countries (Castella et al , ; Almasri et al , ; Isikdogan et al , ; Abdel‐Fattah & Yassine, ; Sahni & Desai, ; Akhtar et al , ; Goldman et al , ; Ameen et al , ; Mozaheb et al , ; Yaqo et al , ; Arora et al , ; Otrock et al , ; Mondal et al , ), but no systematic, large‐scale study of the distribution of NHL subtypes in this region has been published to date. The aim of this study was to assess the relative frequencies of NHL subtypes in NAF/ME/IN and compare the findings to a previously accrued cohort from North America (NA) (Anderson et al , ).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Relative frequency of non‐Hodgkin lymphoma subtypes in selected centres in North Africa, the middle east and India: a review of 971 cases

Perry

Diébold²,

Nathwani

et al. 2015

Br J Haematol

View full text Add to dashboard Cite

Comparative data regarding the distribution of non-Hodgkin lymphoma (NHL) subtypes in North Africa, the Middle East and India (NAF/ME/IN) is scarce in the literature. In this study, we evaluated the relative frequencies of NHL subtypes in this region. Five expert haematopathologists classified 971 consecutive cases of newly-diagnosed NHL from five countries in NAF/ME/IN. After review, 890 cases (91·7%) were confirmed to be NHL and compared to 399 cases from North America (NA). The male-to-female ratio was significantly higher in NAF/ME/IN (1·8) compared to NA (1·1; P< 0·05). The median ages of patients with low-grade (LG) and high-grade (HG) B-NHL in NAF/ME/IN (56 and 52 years, respectively) were significantly lower than in NA (64 and 68 years, respectively). In NAF/ME/IN, a significantly lower proportion of LG B-NHL (28·4%) and a higher proportion of HG B-NHL (58·4%) were found compared to NA (56·1% and 34·3%, respectively). Diffuse large B-cell lymphoma was more common in NAF/ME/IN (49·4%) compared to NA (29·3%), whereas follicular lymphoma was less common in NAF/ME/IN (12·4%) than in NA (33·6%). In conclusion, we found significant differences in NHL subtypes and clinical features between NAF/ME/IN and NA. Epidemiological studies are needed to better understand the pathobiology of these differences.

show abstract

Classification of malignant lymphoma subtypes in Korean patients: a report of the 4th nationwide study

Jung

Huh

et al. 2019

J Hematopathol

View full text Add to dashboard Cite

To determine the relative frequency and change of malignant lymphoma in Korea according to the 4th World Health Organization (WHO) classification and compare with previous reports. Between 2015 and 2016, 7737 new patients with malignant lymphoma were enrolled from 31 institutes, with their clinicopathologic information obtained, and evaluated for the relative frequency of lymphoma subtypes. The relative frequency of non-Hodgkin lymphoma (NHL) was 94.8%, and that of Hodgkin lymphoma (HL) was 5.2%. B cell lymphomas accounted for 83.1% of all NHLs; T/natural killer (NK) cell lymphomas, 16.4%; and immunodeficiency-associated lymphoproliferative disorders, 0.5%. The most common NHL subtypes were diffuse large B cell (41.5%), extranodal marginal zone (MALT, 19.8%), follicular (7.5%), NK/ T cell (4.2%), and peripheral T cell lymphomas, not otherwise specific (PTCL, NOS, 3.4%). Nodular sclerosis was the predominant HL subtype (48.5%), followed by mixed cellularity (28.7%), lymphocyte-rich (6.8%), lymphocyte-depleted (1.5%), lymphocyte-predominant (2.8%), and unclassified HL (11.8%). Compared with a previous report, increased B cell lymphomas (77.6-83.1%) and slightly decreased NK/T cell lymphomas and PTCL were observed. The incidence of follicular lymphoma increased by more than 2.5-fold (2.9-7.5%). Incidence rates of newly diagnosed lymphomas were lower for HL and higher for extranodal NHL, MALT, and nasal type NK/T cell lymphomas in Korea than those in Western countries. A slight increase in the relative frequency of B cell lymphoma and a prominent increase in follicular lymphoma may be attributed to refined diagnostic criteria and Westernized disease patterns.

show abstract

Malignant lymphoma in Eastern India: A retrospective analysis of 455 cases according to World Health Organisation classification

Cited by 13 publications

References 12 publications

Spectrum of Malignant Lymphoma in a Tertiary Care Hospital of North Eastern India

Spectrum of Malignant Lymphoma in a Tertiary Care Hospital of North Eastern India

Relative frequency of non‐Hodgkin lymphoma subtypes in selected centres in North Africa, the middle east and India: a review of 971 cases

Classification of malignant lymphoma subtypes in Korean patients: a report of the 4th nationwide study

Contact Info

Product

Resources

About