Malignant Lymphoma of the Testis: A Clinicopathologic Study of 37 Cases

Sussman, Edward B.; Hajdu, Steven I.; Lieberman, Philip; Whitmore, Willet F.

doi:10.1016/s0022-5347(17)58277-4

Cited by 91 publications

(37 citation statements)

References 10 publications

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“…TNHL has a predilection for spreading to non-contiguous extranodal sites, especially the central nervous system (CNS). [1][2][3][4][5][6] The majority of reported TNHL cases present diffuse histology, and usually B-cell type. 1,3,4,[7][8][9] As it is a rare tumor, and population-based studies are few, its treatment is controversial, especially regarding its early stage.…”

Section: Introductionmentioning

confidence: 99%

Primary testicular non-Hodgkin's lymphoma: a review article

et al. 2007

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Primary testicular non-Hodgkin's lymphoma was first described as a clinical entity in 1866. It is a rare disease and accounts for 1% of all non-Hodgkin's lymphoma, 2% of all extranodal lymphomas and 5% of all testicular neoplasms. It is the most common testicular tumor in males between sixty and eighty years of age. Testicular non-Hodgkin's lymphoma is unique in its high incidence of bilateral involvement (8-38%), and it is also the most common bilateral testicular tumor. Testicular non-Hodgkin's lymphoma has a predilection for spreading to non-contiguous extranodal sites, especially the central nervous system. Advanced-stage disease is usually managed with doxorubicin-based chemotherapy. For early-stage disease, opinion is divided regarding systemic chemotherapy following orchidectomy. The high incidence of spreading, especially to the central nervous system, leads to advocacy of the use of central nervous system prophylaxis with intrathecal chemotherapy. Prospective multicenter trials incorporating a large number of patients may lead to better guidelines for optimal management of this subtype of non-Hodgkin's lymphoma.

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Section: Introductionmentioning

confidence: 99%

Primary testicular non-Hodgkin's lymphoma: a review article

et al. 2007

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“…Other authors have reported the incidence of bilateral involvement of about 10-40%. [1][2][3][4][5][6][7]12,15 …”

Section: Affected Age Group and Bilateralitymentioning

confidence: 99%

“…1,4,6,9 TNHL has a predilection for dissemination to non-contiguous extranodal sites such as the CNS, Waldeyer's ring, skin and lungs. 1,4,10,12 Martenson et al reported a 10% incidence of CNS involvement in the initial failure and 20% in subsequent relapses.…”

Section: Etiological Factors and Dissemination Patternsmentioning

confidence: 99%

“…1,13 Histopathological differentiation of TNHL from seminoma is usually a challenge. 6 Other conditions that might resemble TNHL are embryonal cell carcinoma, granulomatous orchitis, pseudolymphoma, plasmacytoma and rhabdomyosarcoma. 1,3,6 Serum lactate dehydrogenase (LDH) levels have been correlated with tumor aggressiveness, whereas other tumor markers such as serum beta human chorionic gonadotropin (HCG) and serum alpha-fetoprotein (AFP) are rarely elevated in TNHL cases.…”

Section: Histological Classificationmentioning

confidence: 99%

“…6 Other conditions that might resemble TNHL are embryonal cell carcinoma, granulomatous orchitis, pseudolymphoma, plasmacytoma and rhabdomyosarcoma. 1,3,6 Serum lactate dehydrogenase (LDH) levels have been correlated with tumor aggressiveness, whereas other tumor markers such as serum beta human chorionic gonadotropin (HCG) and serum alpha-fetoprotein (AFP) are rarely elevated in TNHL cases. 13 Abbadi A et al studied 18 patients and classified their disease as primary testicular lymphoma with germinal center B-cell-like and non-germinal center B-cell-like by means of the IHC expression of CD10, Bcl-6 and MUM1.…”

Section: Histological Classificationmentioning

confidence: 99%

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A rare case of non-Hodgkins lymphoma of testis: case study and review of literature

Sreeramulu¹,

Hareen²,

Rakesh³

et al. 2017

Int Surg J

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Primary testicular lymphoma is a rare non-Hodgkin’s lymphoma, usually seen in people around 50 years. It accounts for 1% of all non-Hodgkin’s lymphoma. It usually involves bilateral testes. Orchidectomy followed by chemotherapy is the treatment modality. Central nervous system is the common site for extra nodal site followed by skin, lung, and pleura. A 70 years old male patient presented with complaint of painless swelling of the left testes since 1 year. On examination left testes enlarged in size measuring around 8x5x4 cm. Ultrasound showed features suggestive of malignancy? Seminoma left testes. Orchidectomy was done and sent for histopathological examination. Histopathological report showed features of non-hodgkin’s lymphoma. Patient was started with systemic chemotherapy. 3 cycles of CHOP regimen was given to the patient at 21 days interval. Primary testicular tumour being a rare condition, early diagnosis and treatment with orchidectomy followed by chemotherapy is the first choice. Prognosis is poor. Secondary spread to CNS advocates the use of intrathecal chemotherapy.

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