Malignant lymphoma: reactive with the monoclonal antibody fmc-7

Collins, Russell J.; Bunce, Ian; Clarke, E.C.; Conroy, Jeff; Forsythe, Alice M.; Neil, J.; Searle, Jeffrey; Winlaw, Patricia Barbara; Woodford, P.A.; Brooks, David A.; Bradley, John; Zola, Heddy

doi:10.1016/s0031-3025(16)38199-5

Cited by 4 publications

(2 citation statements)

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“…FMC-7 has been used to analyse single cell suspensions prepared from lymph nodes from patients with malignant lymphoma and 10 of 43 were positive (Collins et al, 1983). These fell into no distinct histopathological category although imprints suggested that the cells were of follicular origin.…”

Section: Discussionmentioning

confidence: 99%

A cytological analysis of FMC‐7 positive leukaemias

Hart

Beard

Hamer

et al. 1986

Hematological Oncology

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The subdivision of the B lymphoid leukaemias by conventional techniques is subjective and poorly reproducible, with a range of cytological diagnoses available for cases which are not typical examples of chronic lymphatic leukaemia or acute lymphoblastic leukaemia. The monoclonal antibody FMC-7 recognizes a determinant on a subpopulation of B lymphoid cell and stains follicular B cells. Routiune FACS analysis of chronic lymphoid leukaemias with a panel of monoclonal antibodies identified a subset of lymphoproliferative disorders (20 of 88) which were FMC-7 positive. a careful 'blind' cytological assessment of this subset gave some support for the suggestion that they were examples of lymphoproliferative disease of follicular origin. Eight cases, however, were considered cytologically typical of CLL. The wider application of this antibody, particularly in sequential studies over a longer time scale may improve objectivity in the classification of this group of diseases.

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Section: Discussionmentioning

confidence: 99%

A cytological analysis of FMC‐7 positive leukaemias

Hart

Beard

Hamer

et al. 1986

Hematological Oncology

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“…The majority of cells in suspension (82-97%) from JK, SH, AT and SA were negative for the B cell subset antibody FMC 7, which reacts preferentially with neoplastic cells in prolymphocytic leukaemia and variably with neoplastic cells in lymphoma (Catovsky et al, 1981;Collins et al, 1983 (1979). In this article and a subsequent paper (Haegert, 1981) it is claimed that the majority of "null" lymphocytes are of B cell lineage by virtue of surface Ig demonstrable by the mixed antiglobulin technique.…”

Section: Enzyme Linked Immunoabsorbent Assaymentioning

confidence: 99%

Immunoglobulin negative follicle centre cell lymphoma

Gregg¹,

Al-Saffar²,

Jones³

et al. 1984

Br J Cancer

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Immunohistological Diagnosis of Primary Brain Lymphoma Using Monoclonal Antibodies: Confirmation of B—Cell Origin

Garson

Bourne

Allan

et al. 1988

Neuropathology Appl Neurobio

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The antigenic characteristics of 20 primary cerebral lymphomas have been defined by their reactivity with a panel of monoclonal antibodies recognizing differentiation antigens of lymphocytes and other cell types. In 7 out of 20 cases (35%), immunohistological results were diagnostically crucial and this approach appeared almost to double the detection rate of brain lymphomas over a 10-year period. All 20 tumours were confirmed as B-cell neoplasms by the use of a monoclonal antibody (B-1) specific for B-lymphocytes, rather than by the demonstration of immunoglobulin production. Further immunophenotyping with antibody FMC7 indicated that the neoplastic B-cells had been 'arrested' at a relatively mature stage of differentiation. The importance of monoclonal antibody markers in the accurate diagnosis and characterization of primary cerebral lymphomas has now been established.

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Malignant lymphoma: reactive with the monoclonal antibody fmc-7

Cited by 4 publications

References 0 publications

A cytological analysis of FMC‐7 positive leukaemias

A cytological analysis of FMC‐7 positive leukaemias

Immunoglobulin negative follicle centre cell lymphoma

Immunohistological Diagnosis of Primary Brain Lymphoma Using Monoclonal Antibodies: Confirmation of B—Cell Origin

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