Malignant Melanoma of the Choroid in the Nevus of Ota

Yamamoto, Tomohiko

doi:10.1159/000305882

Cited by 22 publications

(4 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although nevus of Ota is uncommon in the Caucasian population, it should not be surprising that a review of English language journals would result in a preponderance of Caucasian cases. Yamamoto [11] reported a case of cho roidal malignant melanoma in a Japanese patient with nevus of Ota. His review of the literature noted 2 prior cases in Japanese males.…”

Section: Discussionmentioning

confidence: 99%

“…Two patients were described with ipsilateral increase in intraocular pressure by applana tion tonometry consistent with open-angle glaucoma [5,17], These melanomas arose in the iris [ 17] and choroid [5]. Two other patients [ 11,22] had an increase in their ipsilat eral intraocular pressure without a change in visual acuity. Orbital lesions frequently presented with unilateral exoph thalmos [25.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Malignant Melanoma in a Hispanic Male with Nevus of Ota

Shaffer¹,

Walker²,

Weiss³

1992

Dermatology

View full text Add to dashboard Cite

Nevus of Ota is uncommon in the non-Oriental population. We report a case of malignant melanoma with metastasis to the genitourinary tract in a Hispanic male with nevus of Ota. Thirty-six prior cases of nevus of Ota with malignant melanoma reported in the English language are reviewed. Sixty-eight percent were women; 76% were Caucasians. Metastatic disease was reported in 16%. Three patients had liver metastases. Our case was the first involving the genitourinary tract. All but one patient with metastatic disease died within 1 month of presentation. Despite the increased frequency of nevus of Ota in the Japanese, only 4 cases of malignant melanoma have been reported. Nevus of Ota would appear to be a risk factor for developing malignant melanoma in the Caucasian population.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Malignant Melanoma in a Hispanic Male with Nevus of Ota

Shaffer¹,

Walker²,

Weiss³

1992

Dermatology

View full text Add to dashboard Cite

show abstract

“…A total of 10 arose within nevi of Ota and 3 in nevi of Ito . In addition to these cutaneous melanomas arising in association with nevi of Ota and Ito, over 40 cases of primary melanoma of the uveal tract (choroid, iris and ciliary body), orbital soft tissues, central nervous system, meninges and dura have been reported in association with nevi of Ota . We could not identify reports of malignant transformation of Mongolian spot.…”

Section: Summary Of Cases Of Primary Cutaneous Melanoma Arising In Thmentioning

confidence: 87%

Melanoma arising in a nevus of Ito: novel genetic mutations and a review of the literature on cutaneous malignant transformation of dermal melanocytosis

et al. 2015

View full text Add to dashboard Cite

Dermal melanocytosis refers to a spectrum of benign melanocytic proliferations that includes Mongolian spot, nevus of Ota and nevus of Ito. These lesions most commonly occur in persons of Asian or African descent and are often present at birth or develop during childhood. Very rarely, dermal melanocytoses undergo malignant transformation. There have been only 13 reports in the literature of primary cutaneous melanoma arising in dermal melanocytoses. We report a case of a Chinese woman with melanoma arising in a congenital nevus of Ito. We performed targeted next-generation sequencing of the tumor which revealed mutations of GNAQ and BAP1, suggesting that alterations in these two genes led to malignant transformation of the nevus of Ito. We also provide a summary of reports in the literature regarding primary cutaneous melanoma arising in the context of dermal melanocytosis.

show abstract

“…Ocular (oculodermal) melanocytosis is a congenital condition characterised by dermal pigmentation along the first and second divisions of the trigeminal nerve such as the ocular coats and periocular skin 1. It has been well established in literature that ocular melanocytosis predisposes to uveal malignant melanoma 2–11. Melanocytoma is a low-grade pigmented tumour arising from the melanocytes 1.…”

Section: Introductionmentioning

confidence: 99%

Congenital choroidal melanocytoma in a child with ocular melanocytosis

2019

View full text Add to dashboard Cite

A 1-day-old child was brought to the clinic for evaluation of enlarged right eye (OD). On examination, OD showed buphthalmos with diffuse scleral melanocytosis, fleshy blackish-brown extrascleral mass with corneal extension, and secondary glaucoma. Anterior segment evaluation revealed darkly pigmented iris and fundus evaluation OD revealed a darkly pigmented choroidal lesion. The left eye was within normal limits. A clinical diagnosis of choroidal melanocytoma with ocular melanocytosis was made. Enucleation OD followed by orbital implant was performed. Histopathology showed features of diffuse ocular melanocytosis involving limbus, iris, ciliary body, choroid, sclera, optic nerve head, optic nerve sheath, along with choroidal melanocytoma with extrascleral tumour extension. We presume that choroidal melanocytoma may have arisen from ocular melanocytosis.

show abstract

Malignant Melanoma of the Choroid in the Nevus of Ota

Cited by 22 publications

References 4 publications

Malignant Melanoma in a Hispanic Male with Nevus of Ota

Malignant Melanoma in a Hispanic Male with Nevus of Ota

Melanoma arising in a nevus of Ito: novel genetic mutations and a review of the literature on cutaneous malignant transformation of dermal melanocytosis

Congenital choroidal melanocytoma in a child with ocular melanocytosis

Contact Info

Product

Resources

About