Malignant melanoma of the oral cavity: Report of two cases

Munde, Anita; Juvekar, Monica Vivek; Karle, Ravindra; Wankhede, Pranali

doi:10.4103/0976-237x.132352

Cited by 11 publications

(4 citation statements)

References 10 publications

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“…Additionally, abnormal melanocytes high mitotic rate and vascular or brain invasion are other variables linked to a bad prognosis. In our case, the patient was in stage I at the time of the diagnosis, according to Munde et al [ 17 ] and Sahana Ashok et al [ 18 ]. Patients with low socioeconomic backgrounds usually have poor prognoses due to limited financial resources, especially in India which was seen in our case.…”

Section: Discussionmentioning

confidence: 88%

Oral malignant melanoma of the lower jaw—a case report with immunohistochemical investigations

Tamgadge,

Pereira,

Date

et al. 2023

ecancer

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Oral mucosal melanoma is a type of pigment-producing cell malignancy that primarily affects the skin and oral mucosa, but can also affect the ears, eyes, gastrointestinal tract and vaginal mucosa. Oral mucosal melanoma has several different clinical manifestations. Even though it frequently manifests as a black-brown patch, macule, or nodular lesion with varying tones of red, purple or depigmented tissue, the clinical characteristics and pathobiological behaviour of oral mucosal melanomas differ from those of cutaneous melanomas. The prognosis for oral melanomas is exceedingly bad because they frequently exhibit no symptoms, which may delay diagnosis. The case of a 65-year-old male patient with a primary complaint of blackened gums in the right lower back region of the jaw is presented here.

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Section: Discussionmentioning

confidence: 88%

Oral malignant melanoma of the lower jaw—a case report with immunohistochemical investigations

Tamgadge,

Pereira,

Date

et al. 2023

ecancer

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“…Even tumor node metastasis (TNM) staging for cutaneous melanomas needs to applied with caution while treating oral melanomas. [ 14 ] According to the American Joint Committee on Cancer (AJCC) TNM classification for mucosal melanoma of the head and neck,[ 15 ] both the above cases were T3, N0, M0, making them be in Stage III of the disease. It is to be noted that the AJCC staging for mucosal melanomas of the head and neck begins at Stage III owing to the extensive tumor during the initial presentation.…”

Section: Discussionmentioning

confidence: 99%

Primary malignant melanoma of oral mucosa – Report of two cases

Shetty

Deepa

2020

Contemp Clin Dent

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Primary malignant melanoma of oral mucosa is a rare and aggressive tumor. It is usually seen in the 5 th and 6 th decades of life. Its mainstay of treatment is surgery. It has a very poor prognosis, which is attributed to its late detection and distant metastasis. Dentists are often the first clinicians to come across these lesions and need to be able to identify them at the earliest for a better prognosis. In this article, we present two cases of extensive primary malignant melanoma of the oral cavity. Clinically, both the cases had a similar appearance of grayish-black pigmented nodular swelling on the buccal aspect and grayish-black discoloration on the palatal aspect. There were no significant radiological changes in both cases, indicating the superficial spread of the lesion. A positron emission tomography scan was performed in the second patient, which did not show any distant metastasis. Surgery was advised as a treatment for both the patients.

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“…However, these cells are also present in many sun-shielded sites, such as the oral cavity, where their function is not clearly understood, but there is evidence supporting an antimicrobial and immunological activity [ 8 , 9 ]. Proliferation of atypical melanocytes at the interface between the epithelium and connective tissue is presumed to be the origin of MM; moreover, exposure to inhaled carcinogens such as tobacco could provoke the malignant transformation of those atypical melanocytes [ 1 , 10 , 11 ]. In fact, while some molecular alterations in genes such as c-KIT , BRAF , and NRAS have been found, their presence is extremely variable; nevertheless, cigarette smoking has been considered a risk factor because it usually promotes pigmented oral lesions and their potential transformation into malignant ones [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Mucosal Melanoma of the Hard Palate: Surgical Treatment and Reconstruction

Bondi

Vinciguerra

Lissoni

et al. 2021

IJERPH

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Mucosal melanomas of the head and neck region are uncommon pathologies that can affect the oral cavity, and are characterized by a high rate of mortality. Considering the lack of knowledge regarding risk and prognostic factors, current best clinical practice is represented by a large surgical excision with disease-free margins, eventually associated with a reconstructive flap. Indeed, given the frequent necessity of postoperative radiotherapy and fast healing process, a reconstruction of the surgical gap is advisable. Even if several flaps have been most commonly used, the submental island flap represents a valid alternative thanks to local advantages and similar oncologic outcomes compared to free flaps.

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Malignant melanoma of the oral cavity: Report of two cases

Cited by 11 publications

References 10 publications

Oral malignant melanoma of the lower jaw—a case report with immunohistochemical investigations

Oral malignant melanoma of the lower jaw—a case report with immunohistochemical investigations

Primary malignant melanoma of oral mucosa – Report of two cases

Mucosal Melanoma of the Hard Palate: Surgical Treatment and Reconstruction

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