Malignant mesenchymoma arising from a uterine leiomyoma in the menopause

Kew, C.; Putti, Thomas Choudary; Razvi, Khalil

doi:10.1016/j.ygyno.2004.08.014

Cited by 16 publications

(12 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Tumors that contain two or more lineages of specialized differentiation have sometimes been described as "malignant mesenchymomas" in the past [3,12,15,16]. Since the group of malignant mesenchymomas represents no homogeneous clinicopathological entity, and the majority of tumors considered to be mesenchymomas can be classified in other ways (especially dedifferentiated liposarcomas), this entity seems to be gradually disappearing.…”

Section: Discussionmentioning

confidence: 99%

Recurrent high-grade leiomyosarcoma with heterologous osteosarcomatous differentiation

et al. 2005

View full text Add to dashboard Cite

Leiomyosarcomas (LM) of the soft tissue comprise approximately 5-10% of all soft tissue sarcomas. Besides the classic LM, several distinctly uncommon features of the cellular and growth patterns of LM have been described. The term "dedifferentiated LM" has rarely been used in the literature to describe soft tissue LM containing areas of undifferentiated, pleomorphic appearance or detectable heterologous differentiation. We report on a case of high-grade LM with almost entire transition to an osteosarcoma, which was classified as recurrent high-grade LM with heterologous osteosarcomatous differentiation. The identification of areas with osteosarcomatous dedifferentiation in soft tissue sarcomas can be of clinical importance because of a possible change in oncologic treatment strategies.

show abstract

Section: Discussionmentioning

confidence: 99%

Recurrent high-grade leiomyosarcoma with heterologous osteosarcomatous differentiation

et al. 2005

View full text Add to dashboard Cite

show abstract

“…Although primary uterine osteosarcomas are well described [12], heterologous osteoid elements are extraordinarily rare in the uterine leiomyosarcomas. Previously reported examples of this phenomenon include 2 cases of complex tumors, reported as mesenchymomas , with leiomyosarcomatous, osteosarcomatous, and liposarcomatous elements [13, 14], 1 case of a mixed osteosarcoma/leiomyosarcoma [15] and 1 case of a conventional uterine leiomyosarcoma that metastasized as a high-grade sarcoma with a multitude of heterologous malignant mesenchymal elements that included osteosarcomatous, chondrosarcomatous, and liposarcomatous areas [16]. In 3 of these 4 cases, myogenic areas were clearly demonstrable either morphologically or immunohistochemically in the heterologous areas [13–15].…”

Section: Discussionmentioning

confidence: 99%

Dedifferentiated Leiomyosarcoma of the Uterus with Heterologous Elements: A Potential Diagnostic Pitfall

Rawish

Fadare

2012

Case Reports in Obstetrics and Gynecology

View full text Add to dashboard Cite

Dedifferentiation is a phenomenon that is well characterized in a variety of tumors and is defined by the occurrence of a high-grade or undifferentiated tumor, typically unrecognizable regarding its line of differentiation, from a low-grade/borderline neoplasm. This phenomenon has previously been described in 2 uterine leiomyosarcomas, but both were devoid of heterologous elements. The authors describe herein a case of a dedifferentiated leiomyosarcoma of the uterus with osteoid heterologous elements, believed to be the first such reported case. The original tumor was a high-grade leiomyosarcoma with large low-grade and leiomyoma-like areas and whose constituent cells displayed intense nuclear immunoreactivity for both estrogen receptor (ER) and progesterone receptor (PR) in approximately 30% of cells. The tumor recurred six months after its resection as an undifferentiated sarcoma that was negative for smooth muscle markers, but which remained positive for ER and PR. Osteoid production was only identified in the recurrent tumor and was significant in extent therein. This case highlights the immunophenotypic changes that may occur in dedifferentiated leiomyosarcomas, and this possibility should be a consideration when an apparently undifferentiated sarcoma is identified in a patient with a history of uterine leiomyosarcoma. In our case, the expression of ER and PR provided significant supportive evidence of the uterine origin of the recurrent tumor.

show abstract

“…It is documented that uterine leiomyosarcomas are aggressive tumors with an overall poor prognosis (15% to 25% 5-yr survival rate) (13). Although there are a limited number of cases, the behavior of uterine lipoleiomyosarcoma can correlate with leiomyosarcomas and other uterine sarcomas with heterologous components (3,14), which have a poor prognosis with long-term follow-up. Although there has been limited experience on treatment modality, postoperative adjuvant therapy is mandatory.…”

Section: Uterine Lipoleiomyosarcomamentioning

confidence: 99%

Uterine Lipoleiomyosarcoma

Lee

Tseng

Hsieh

et al. 2012

International Journal of Gynecological Pathology

View full text Add to dashboard Cite

Uterine lipoleiomyosarcoma is a rare entity with only 6 case reports in the Pubmed database at the time of writing this article. We report 2 additional cases of uterine lipoleiomyosarcoma, characterized on microscopy by coexistence of leiomyosarcomatous and liposarcomatous components, with focal intermingling, without an intervening lipoleiomyomatous area. The liposarcomatous component in both of our cases had the morphology of myxoid liposarcoma. Both cases underwent postoperative chemotherapy. One of our cases had recurrence in the pelvis with microscopic features of myxoid liposarcoma. This patient died with multiple metastases 4.5 yr after hysterectomy, with the metastatic lesions being liposarcomas, without an evident leiomyosarcomatous component. Although lacking a treatment protocol because of the rarity of such cases, postoperative adjuvant therapy is mandatory.

show abstract

Malignant mesenchymoma arising from a uterine leiomyoma in the menopause

Cited by 16 publications

References 13 publications

Recurrent high-grade leiomyosarcoma with heterologous osteosarcomatous differentiation

Recurrent high-grade leiomyosarcoma with heterologous osteosarcomatous differentiation

Dedifferentiated Leiomyosarcoma of the Uterus with Heterologous Elements: A Potential Diagnostic Pitfall

Uterine Lipoleiomyosarcoma

Contact Info

Product

Resources

About