Malignant Mesothelioma and Its Nonasbestos Causes: Talcum Powder Does Not Create Occult Asbestos Exposure

Geyer, Stanley J.

doi:10.5858/arpa.2019-0388-le

Cited by 3 publications

(1 citation statement)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Asbestos or asbestiform fibers were not detected in the talc mined and processed in Val Chisone (Rubino et al, 1976(Rubino et al, , 1979Pooley, 1973;Verdel et al, 1983;Parkes, 1994). Some recent allegations of possible contamination by asbestos (Gordon et al, 2014;Finkelstein, 2017Finkelstein, , 2019 were not supported by empirical evidence (Pira et al, 2017b;Geyer, 2019). The results of the analyses of additional samples collected between 2017 and 2020 confirm that talc from Val Chisone is pure talc with no detectable level of asbestos (Table 4).…”

Section: Discussionmentioning

confidence: 92%

Mortality in the cohort of talc miners and millers from Val Chisone, Northern Italy: 74 years of follow-up

Ciocan

Pira

Coggiola

et al. 2022

Environmental Research

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 92%

Mortality in the cohort of talc miners and millers from Val Chisone, Northern Italy: 74 years of follow-up

Ciocan

Pira

Coggiola

et al. 2022

Environmental Research

View full text Add to dashboard Cite

Malignant mesothelioma following exposure to cosmetic talc: Association, not causation

Geyer¹

2020

American J Industrial Med

View full text Add to dashboard Cite

Malignant Peritoneal Mesothelioma Arising in Young Adults With Long-standing Indwelling Intra-abdominal Shunt Catheters

Mujahed

Tazelaar

Sukov

et al. 2020

American Journal of Surgical Pathology

View full text Add to dashboard Cite

Only 50% to 70% of patients with mesothelioma report asbestos exposure. Other exposures (eg, radiation) play a role in some cases, but some patients have no obvious cause. We describe a series of patients with long-standing indwelling intra-abdominal shunt catheters who developed malignant peritoneal mesothelioma, suggesting a novel association. We identified 7 patients who had shunts and subsequently developed mesothelioma (5 women; median age: 31 y, range: 18 to 45 y). Clinical history and pathology materials were reviewed, and RNA sequencing was performed. Clinical presentations varied; 6 patients had hydrocephalus and a ventriculoperitoneal shunt, and 1 patient had portal hypertension and a portoatrial shunt. The median duration of shunt therapy in 5 cases was 29 years (range: 12 to 35 y); the remaining 2 patients also had shunts for many years, but specific details were unavailable. Two patients had radiotherapy for malignancies in childhood. One had an alleged exposure to asbestos and 1 had prior exposure to talc. The rest had no known risk factors. Histologically, all tumors were purely epithelioid. Treatments included surgical debulking, chemotherapy, and palliative care. All 7 died of disease (median survival: 7 mo, range: 1 to 18 mo). Molecular testing showed loss of NF2 and CDKN2A/B and a BAP1 mutation in 1 case, and no genomic alterations associated with mesothelioma in 2 cases. Peritoneal mesothelioma may represent a complication of long-standing indwelling shunt catheters. The mechanism is unknown, but chronic peritoneal irritation may play a role. Albeit rare, mesothelioma should be considered in patients with a shunt who present with new ascites.

show abstract

Malignant Mesothelioma and Its Nonasbestos Causes: Talcum Powder Does Not Create Occult Asbestos Exposure

Cited by 3 publications

References 8 publications

Mortality in the cohort of talc miners and millers from Val Chisone, Northern Italy: 74 years of follow-up

Mortality in the cohort of talc miners and millers from Val Chisone, Northern Italy: 74 years of follow-up

Malignant mesothelioma following exposure to cosmetic talc: Association, not causation

Malignant Peritoneal Mesothelioma Arising in Young Adults With Long-standing Indwelling Intra-abdominal Shunt Catheters

Contact Info

Product

Resources

About