Malignant Mesothelioma in Urban Dogs

Harbison, Margaret L.; Godleski, John J.

doi:10.1177/030098588302000504

Cited by 68 publications

(55 citation statements)

References 10 publications

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“…Although most studies described that canine mesotheliomas have been seen with both pleural and pericardial effusion [2,4,5,7,8], in our case we did not determine any evidence of pericardial effusion and even effusion in abdominal cavity.…”

Section: Discussioncontrasting

confidence: 86%

“…On the other hand, mesothelioma was associated with exposure of asbestos in humans and animals [2][3][4]9]. In our clinical case we did not confirm any contact of the dog with asbestos or larger amount of pesticides, which are described as etiological factors of mesothelioma.…”

Section: Discussioncontrasting

confidence: 66%

“…It was reported that dogs aged 8 years or more predisposed to this disorder [1][2][3]. The clinical and pathological features of the tumor have been examined with many studies but associated etiologic or epidemiologic factors have not been described.…”

mentioning

confidence: 99%

“…The clinical and pathological features of the tumor have been examined with many studies but associated etiologic or epidemiologic factors have not been described. In some studies and case reports, malignant mesotheliomas have been induced in dogs exposed to intratracheal instillation of crocidolite asbestos and cigarette smoke [2,4]. Although some studies have been revealed that canine mesotheliomas present clinically with peritoneal effusion, most mesotheliomas have seen with pleural or pericardial effusions [5,6].…”

mentioning

confidence: 99%

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Pleural Effusion in a Dog with Mesothelioma

Ülgen¹,

Bakırel²,

KutayYıldız³

et al. 2015

JLS

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In this case; mesothelioma was likely diagnosed in 7 years old male mix breed dog which was brought to Veterinary Research and Teaching Hospital of Istanbul University with complaints of general weakness and severe dyspnea. The dog had been misdiagnosed with faryngitis and hernia diaphragmatica before it was brought to our faculty clinic. Apparent abdominal respiration was inspected and supressed heart sounds, abnormal respiratory sounds and pleural rub were detected by auscultation of thorax. Radiographic examination and blood analysis were performed. Chest X-ray examination demonstrates both sided pleural effusion. Leukocytosis (WBC = 36.2  10 3 µL) was detected on blood count. By thoracocentesis, 40 mL fluid was drained and cytologic examination was performed. Numerous pleomorphic, atypical, multinuclear or multinucleolar mesothelial cells were observed and cytologic findings were pretty compatible with mesothelioma. The dog died before medication and the owner of the dog didn't give the confirmation for necropsy. In our clinical case we did not confirm any contact of the dog with asbestos or larger amount of pesticides, which are described as etiological factors of mesothelioma. As mesothelioma is a very rare health condition for dogs, it might be lead up to misdiagnosis.

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Section: Discussioncontrasting

confidence: 86%

Section: Discussioncontrasting

confidence: 66%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Pleural Effusion in a Dog with Mesothelioma

Ülgen¹,

Bakırel²,

KutayYıldız³

et al. 2015

JLS

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“…The most prominent and reliable clinical finding in mesothelioma is respiratory distress caused by pleural exudation or abdominal distention due to peritoneal fluid accumulation. Also typical are excess effusions in cavities caused by exudation and infiltration on tumourous surfaces or lymphatic vessels under the pressure of tumourous tissues (Harbison and Godleski 1983;Ogilvie and Moore 2006). Classical mesotheliomas are diffuse nodular multifocal masses that cover the body cavities (Head et al 2002).…”

mentioning

confidence: 99%

Pericardial mesothelioma in a German Shepherd dog: a case report

Çeribaşı¹,

Özkaraca²,

Çeribaşı³

et al. 2013

Vet. Med. - Czech

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ABSTRACT:In this case report, a diagnosis of pericardial mesothelioma in a four year old male German shepherd dog is described. The dog, which had anorexia, bloody diarrhoea, dehydration and depression and, died on day 10 of therapy, was systematically necropsied. At necropsy, approximately 1.5 litres of cloudy and bloody exudate were detected in the thoracic cavity. The parietal lamina of the pericardium was covered with multilobular nodular masses related with each other, 1 to 5 cm in diameter and grey-yellow in colour. There were proliferations characterised with grey-yellow colour and approximately 1 to 5 mm in length on visceral pleura. The presence of abscess foci with liquefied-centrum was observed when examining a section surface of the lung. The appearance of the oesophageal serosa, thoracic aorta and the thoracic section of the diaphragm were similar to pleura. A thickening was microscopically determined in the parietal lamina of the pleura and pericardium due to papillary proliferations consisting of cells similar to cubic or cylindrical epithelium. Severe lymphocyte and plasma cell infiltrations were observed in the pleural sections next to the lung. Neoplastic cells had nuclei with large eosinophilic granular cytoplasms and large vesicular and single nucleoli. Some neoplastic cells were determined to include intracytoplasmic vacuoles. The neoplastic cells contained some mitotic figures. It was observed that some tumour cells contributed to giant cell formation through integration. In periodic acid Schiff-haematoxylin (PAS-H) examinations it was determined that the pleural basal membrane maintained its integrity. Immunohistochemically, the tumour gave a weak positive reaction with anti-pancytokeratin staining while giving intense reaction with anti-vimentin staining.

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