Malignant mesothelioma of the tunica vaginalis testis: a case report and review of the literature

Güney, Neşe; Başaran, Mert; Karayigit, Ebru; Müslümanoğlu, Ahmet Yaser; Güney, Soner; Kiliçaslan, İşın; Gulbarut, Saime

doi:10.1007/s12032-007-0010-3

Cited by 21 publications

(19 citation statements)

References 24 publications

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“…In one study, 9 losses of chromosomal regions in 1p, 8p, 14q, and 22q and gains in 5p, 6p, 8q, 15q, 17q, and 20 were reported. In a separate study, chromosomal abnormalities, such as losses of 1p, 3p, 6q, 9q, and monosomy 22, were shown, 5,7 implying that mesotheliomas harbor multiple cytogenetic abnormalities with no specific diagnostic characteristics. It is not now possible to define the most important genetic alterations involved in the tumorigenesis of mesotheliomas, and future studies will be needed to delineate it at the molecular level.…”

Section: Immunohistochemistrymentioning

confidence: 95%

“…Later, Plas et al 5 reviewed 74 cases of mesothelioma of the tunica vaginalis testis and found that 34.2% had a history of asbestos exposure. [7][8] The latency period from the initial asbestos exposure to the clinical diagnosis is variable but is usually long, sometimes as long as 40 years. 9 CLINICAL FEATURES Mesothelioma of the tunica vaginalis occurs in middleaged to elderly men (mean, 53.5 years); however, there is one case in the literature 10 that describes this entity occurring in the pediatric population.…”

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confidence: 99%

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Malignant Mesothelioma of the Tunica Vaginalis Testis: Diagnostic Studies and Differential Diagnosis

Chekol

Sun²

2012

Archives of Pathology &Amp; Laboratory Medicine

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Malignant mesothelioma of the tunica vaginalis testis is an extremely rare tumor representing 0.3% to 5% of all malignant mesotheliomas. Gross examination of testicular mesotheliomas typically reveals tumor nodules studding the thickened tunica vaginalis and, in some cases, infiltrating the testicular parenchyma, leading to diagnostic challenges. Microscopically, the tumor is characterized by epithelioid cells arising from the tunica vaginalis with papillary, tubulopapillary, or solid architectural patterns. The papillae are usually lined by a single layer of cells with relatively bland cytologic features. An epithelial cell phenotype admixed with a sarcomatoid pattern has also been described in a few cases. Immunohistochemically, the tumor is usually positive for calretinin, Wilms tumor-1, epithelial membrane antigen, D2-40, thrombomodulin, cytokeratin 7, and cytokeratin 5/6. Electron microscopic studies reveal epithelial cells joined by tight junctions, forming lumina, and displaying long microvilli with length to width ratios often greater than 10. The most important differential diagnostic considerations include florid mesothelial hyperplasia, adenomatoid tumor, carcinoma of the rete testis, and serous papillary tumors. In addition, the various types of testicular germ cell tumors should be considered, including seminomas, embryonal carcinomas, and intratubular germ cell tumors, particularly in tumors with testicular parenchymal involvement. Pleomorphic sarcomas should also be considered, particularly when dealing with the biphasic variant. The prognosis for this entity is grave, with a median survival of 23 months. Aggressive therapy with radical orchiectomy remains the mainstay of treatment.

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Section: Immunohistochemistrymentioning

confidence: 95%

mentioning

confidence: 99%

Malignant Mesothelioma of the Tunica Vaginalis Testis: Diagnostic Studies and Differential Diagnosis

Chekol

Sun²

2012

Archives of Pathology &Amp; Laboratory Medicine

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“…These findings strongly suggest that canine MM of the tunica vaginalis testis shares immunophenotypic characteristics with a similar neoplasm reported in human beings. 10 Although the outcome of MM of the tunica vaginalis testis is not known for every reported case in human beings, the overall clinical prognosis for mesothelioma is poor, 4 and, as such, radical orchiectomy should be the first-line therapy. 11 The efficacy of adjuvant chemotherapy and radiotherapy has not yet been clearly determined.…”

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confidence: 99%

Malignant Mesothelioma of the Tunica Vaginalis Testis in a Dog: Histological and Immunohistochemical Characterization

et al. 2011

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Abstract. Histologic and immunohistochemical features of a malignant mesothelioma of the testicular tunica vaginalis in a 9-year-old male mixed-breed dog are reported. The dog had a large scrotal swelling determined by ultrasonography to be a heterogeneous irregular mass characterized by a mixed echogenic pattern and located in the left vaginal canal of the testis. Histologically, the neoplasm was nodular, was poorly demarcated, and consisted of pleomorphic cells that were associated with a significant desmoplastic reaction. By immunohistochemistry, neoplastic cells stained positively for cytokeratin and vimentin and were immunoreactive with an antimesothelial cell monoclonal antibody. Malignant mesotheliomas of tunica vaginalis testis are rare in mammalian species, including dogs.

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“…In rare cases, mesothelioma can also occur in the pericardium (4) or in the testis tunica vaginalis (5). Here …”

Section: Malignant Mesotheliomas Are Rare But Aggressive Tumors Arisimentioning

confidence: 99%

Adrenal Failure Caused by a Retroperitoneal Malignant Mesothelioma

Nomura

Sasano

Okada³

et al. 2009

Intern. Med.

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Malignant mesothelioma of the tunica vaginalis testis: a case report and review of the literature

Cited by 21 publications

References 24 publications

Malignant Mesothelioma of the Tunica Vaginalis Testis: Diagnostic Studies and Differential Diagnosis

Malignant Mesothelioma of the Tunica Vaginalis Testis: Diagnostic Studies and Differential Diagnosis

Malignant Mesothelioma of the Tunica Vaginalis Testis in a Dog: Histological and Immunohistochemical Characterization

Adrenal Failure Caused by a Retroperitoneal Malignant Mesothelioma

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