Malignant mesothelioma secondary to chronic inflammation and old scars. Two new cases and review of the literature

Hillerdal, Gunnar; Berg, J.B. van den

doi:10.1002/1097-0142(19850501)55:9<1968::aid-cncr2820550923>3.0.co;2-9

Cited by 66 publications

(16 citation statements)

References 9 publications

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“…There were also no individuals with MM and a nonmesothelial neoplasm who were known to have conditions that cause chronic serosal inflammation, which has been suggested as a possible inducer of MM. [21][22][23][24] Interestingly, of the types of tumors overrepresented among individuals with MM and second neoplasms in this study, a number are either components of the BAP1 tumor predisposition syndrome or have been reported in BAP1 mutation carriers. 1,3 Recognized BAP1 tumor predisposition syndrome-related nonmesothelial tumors that were overrepresented among individuals with MM in our study population include clear cell renal cell carcinoma, lung carcinoma, ocular melanoma, and meningioma.…”

Section: Discussionmentioning

confidence: 99%

Malignant Mesothelioma in Individuals With Nonmesothelial Neoplasms

Butnor¹,

Pavlisko²,

Sporn³

et al. 2018

Archives of Pathology &Amp; Laboratory Medicine

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Context.-Malignant mesothelioma (MM) is a component of the BAP1 tumor predisposition syndrome. Other than in BAP1 familial studies, nonmesothelial neoplasms in individuals with MM has not been comprehensively assessed.Objective.-To assess the spectrum and prevalence of nonmesothelial neoplasms in individuals with MM.Design.-Individuals with MM and second neoplasms were identified from a database of 3900 MM cases. The expected prevalence of each type of neoplasm was calculated and compared with the actual prevalence in the study population using available Surveillance, Epidemiology, and End Results data and other published data.Results.-Two hundred seventy nonmesothelial neoplasms were identified in 241 individuals (6% of the study population) with MM. Prostate adenocarcinoma was most common. Non-Hodgkin lymphoma, Hodgkin lymphoma, lung carcinoma, urothelial carcinoma, breast carcinoma, chronic lymphocytic leukemia, clear cell renal cell carcinoma, head and neck squamous cell carcinoma, papillary renal cell carcinoma, multiple myeloma/plasmacytoma, meningioma, pleomorphic undifferentiated sarcoma, chronic myelogenous leukemia, ocular melanoma, hepatocellular carcinoma, liposarcoma, and Wilms tumor all were more prevalent than expected.Conclusions.-Nonmesothelial neoplasms are uncommon in individuals with MM, but certain tumor types are increased in prevalence. In an unselected study population with respect to BAP1 status, the prevalence of several tumor types described in BAP1 mutation carriers, including lung carcinoma, clear cell renal cell carcinoma, breast carcinoma, meningioma, pleomorphic undifferentiated sarcoma, and ocular melanoma, was increased.( Although the frequency of second neoplasms in individuals with MM has been examined in the context of familial studies of BAP1 mutation carriers, the prevalence and types of second neoplasms among individuals with MM unselected with regard to BAP1 status are unknown.1 The purpose of this study is to comprehensively assess the spectrum and prevalence of nonmesothelial neoplasms in individuals with MM. DESIGNThis study was approved by the institutional review board at Duke University Medical Center, Durham, North Carolina. A database of one of the authors consisting of 3900 MM cases received for professional and medicolegal consultation from 1982 through 2016 was searched retrospectively for individuals with MM who also had a history of one or more antecedent or synchronous (ie, diagnosed during same hospital admission) nonmesothelial neoplasms. The expected prevalence of each type of nonmesothelial neoplasm was calculated based on the overall estimated prevalence reported by the Surveillance, Epidemiology, and End Results (SEER) program for 2013 and US Census Bureau population data from the same year. 4 As SEER data do not separate renal cancers by histologic type, the expected prevalence for all renal cancers was calculated and we extrapolated the expected prevalence of clear cell renal cell carcinoma and papillary renal cell carcinoma to be less than that of a...

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Section: Discussionmentioning

confidence: 99%

Malignant Mesothelioma in Individuals With Nonmesothelial Neoplasms

Butnor¹,

Pavlisko²,

Sporn³

et al. 2018

Archives of Pathology &Amp; Laboratory Medicine

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“…In the pleura, MM has occurred in individuals without an elevated lung tissue asbestos burden and/or evidence of asbestosis decades after therapeutic pneumothorax or thoracic plombage with Lucite spheres for pulmonary tuberculosis 4 6. Pleural MM has also been reported in individuals with long-standing chronic empyema or recurrent pleural effusions who had no documented exposure to asbestos 3 5.…”

Section: Discussionmentioning

confidence: 99%

Malignant peritoneal mesothelioma and Crohn disease

et al. 2016

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Peritoneal MM occurs rarely in patients with IBD, but interestingly, has only been observed in the setting of CD and not in patients with ulcerative colitis. Chronic inflammation has been associated with the development of MM in rare instances and these three cases suggest that CD with transmural inflammation may also be a precursor. The precise role of CD-related transmural inflammation in the carcinogenesis of peritoneal MM remains to be determined.

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“…The low frequency of pleural NHL in Western countries might be explained by the rarity of chronic pyothorax in these cases. Differential diagnoses such as malignant mesothelioma [6], soft tissue sarcoma [7], and squamous cell carcinoma [8] have been reported to complicate chronic pyothorax. However, lymphomas are the most frequent tumour arising in such a context [2].…”

Section: Discussionmentioning

confidence: 99%

Chest pains complicating an artificial therapeutic pneumothorax

Devouassoux

Lantuéjoul²,

Pison³

et al. 1997

Eur Respir J

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A 56 yr old nonsmoking woman was admitted to hospital in 1985 with left sided chest pain and weight loss. She had a history of pulmonary tuberculosis 35 yrs previously. An extrapleural therapeutic pneumothorax had been performed at that time and was complicated several years later by chronic pyothorax. On admission in 1985, she had no dyspnoea or cough. Physical examination showed decreased breath sounds in the upper left chest. No superficial lymphadenopathy was found. A peripheral white cell count revealed 10.5×10 9 ·L -1 leucocytes, of which 9.15×10 9 ·L -1 were polymorphonuclear cells and 0.6×10 9 ·L -1 were lymphocytes. The erythrocyte sedimentation rate was 60 mm in the first hour.A chest radiograph ( fig. 1) and computed tomographic (CT) scan ( fig. 2) are shown. CASE FOR DIAGNOSIS

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Malignant mesothelioma secondary to chronic inflammation and old scars. Two new cases and review of the literature

Cited by 66 publications

References 9 publications

Malignant Mesothelioma in Individuals With Nonmesothelial Neoplasms

Malignant Mesothelioma in Individuals With Nonmesothelial Neoplasms

Malignant peritoneal mesothelioma and Crohn disease

Chest pains complicating an artificial therapeutic pneumothorax

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