Malignant peritoneal mesothelioma and Crohn disease

Butnor, Kelly J.; Pavlisko, Elizabeth N.; Sporn, Thomas A.; Roggli, Victor L.

doi:10.1136/jclinpath-2016-203945

Cited by 20 publications

(4 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Risk factors included asbestos exposure (4/16, 25%) and personal (5/15, 33%) and/or family (10/12, 83%) history of malignancy; however, genetic testing data were not available. Malignant peritoneal mesothelioma has been rarely described in other chronic inflammatory diseases involving the peritoneum including Crohn disease, familial Mediterranean fever-associated recurrent peritonitis, recurrent peritonitis secondary to diverticulitis and indwelling peritoneal catheters (13)(14)(15). Additional research is needed, but together these data suggest a possible role for chronic inflammatory peritoneal diseases such as endometriosis in promoting tumor progression in peritoneal mesothelioma.…”

Section: Discussionmentioning

confidence: 99%

Progression of Peritoneal Mesothelioma In Situ to Invasive Mesothelioma Arising in the Setting of Endometriosis With Germline BAP1 Mutation: A Case Report

Elliott

Travieso

As‐Sanie

et al. 2021

International Journal of Gynecological Pathology

View full text Add to dashboard Cite

Mesothelioma in situ has been proposed as a precursor to malignant mesothelioma arising in the pleura or peritoneum. We report a case of malignant peritoneal mesothelioma which progressed from mesothelioma in situ over a 10-mo period in a 24-yr-old woman with stage IV endometriosis. Initial surgery showed deeply infiltrative endometriosis with progestin effect. Postoperatively the patient had intractable pelvic pain and vaginal discharge. Imaging studies were negative. Repeat laparoscopy 10 mo later revealed vesicular lesions on the omentum and pinpoint white lesions studding the small bowel, appendix, and pelvic peritoneum. A diagnosis of epithelioid mesothelioma was established on biopsy of the omentum and confirmed by immunohistochemistry showing complete loss of BRCA1-associated protein-1 (BAP1) nuclear staining. Retrospectively, BAP1 loss was identified in the cytologically bland, single-layer surface mesothelium of the prior resection specimen, consistent with mesothelioma in situ. The patient underwent genetic testing and was found to have a pathogenic germline mutation in BAP1.

show abstract

Section: Discussionmentioning

confidence: 99%

Progression of Peritoneal Mesothelioma In Situ to Invasive Mesothelioma Arising in the Setting of Endometriosis With Germline BAP1 Mutation: A Case Report

Elliott

Travieso

As‐Sanie

et al. 2021

International Journal of Gynecological Pathology

View full text Add to dashboard Cite

show abstract

“…In addition, in a model with Crohn's disease, it was also suggested that early inflammatory exudates might lead to the organization of layers of reactive mesothelial cells. [20]. This early reaction would be followed by subacute mesothelial cell proliferation [7].…”

Section: Discussionmentioning

confidence: 99%

Time-Sequential Monitoring of the Early Mesothelial Reaction in the Pleura after Cryoinjury

Kim,

Chae,

Nam

et al. 2024

Diagnostics

View full text Add to dashboard Cite

(1) Background: An early mesothelial reaction of the pleura, leading to fibrosis, has been reported in animals after chemical or heavy metal exposure. However, the visual monitoring of early time-sequential mesothelial reaction-associated cryoinjury has not been fully investigated. Therefore, this study aimed to evaluate and visualize the early mesothelial reactions seen following cryoinjury using rabbit pleura. (2) Methods: We monitored the early mesothelial reaction in rabbit pleurae after cryoinjury using optical coherence tomography (OCT), in real-time, which was then compared with pathological images. Due to the penetration limit of OCT, we made a thoracic window to image the parietal and visceral pleurae in vivo. We also used an innovative technique for capturing the microstructure in vivo, employing a computer-controlled intermittent iso-pressure breath hold to reduce respiratory motion, increasing the resolution of OCT. We organized three sample groups: the normal group, the sham group with just a thoracic window, and the experimental group with a thoracic window and cryotherapy. In the experimental group, localized cryoinjury was performed. The mesothelial cells at the level of pleura of the cryotherapy-injured site were visualized by OCT within the first 30 min and then again after 2 days at the same site. (3) Results: In the experimental group, focal thickening of the parietal pleura was observed at the site of cryoinjury using OCT after the first injury, and it was then confirmed pathologically as focal mesothelial cell proliferation. Two days after cryoinjury, diffuse mesothelial cell proliferation in the parietal pleura was noted on the reverse side around the cryoinjured site in the same rabbit. In the sham group, no pleural reaction was found. The OCT and pathological examinations revealed different patterns of mesothelial cell reactions between the parietal and visceral pleurae: the focal proliferation of mesothelial cells was found in the parietal pleura, while only a morphological change from flat cells to cuboidal cells and a thickened monolayer without proliferation of mesothelial cells were found in the visceral pleural. (4) Conclusions: An early mesothelial reaction occurs following cryoinjury to the parietal and visceral pleurae.

show abstract

“…Peritoneal mesotheliomas have been reported in the context of endometriosis, and the chronic inflammation [100] seen in these cases has been elicited as a possible etiopathogenetic factor, however, other factors, such as personal/familial history of malignancies could also predispose these patients in developing mesothelial malignancy [101]. Similarly, in a database of 3800 mesothelioma patients, three (0.08%) had Crohn disease, while no ulcerative colitis cases were found, also suggesting a role for the transmural inflammation in this context [102]. In the context of peritoneal inflammation, we should also be aware of the mesothelial cysts, formerly named "cystic mesothelioma", and the adenomatoid tumors, both mesothelial lesions potentially associated with inflammatory conditions [103,104], but usually of benign nature.…”

Section: Non-specific Pleuritismentioning

confidence: 96%

Inflammation of the Pleural Cavity: A Review on Pathogenesis, Diagnosis and Implications in Tumor Pathophysiology

Karpathiou

Péoc’h

Sundaralingam

et al. 2022

Cancers

View full text Add to dashboard Cite

Pleural effusions are a common respiratory condition with many etiologies. Nonmalignant etiologies explain most pleural effusions and despite being nonmalignant, they can be associated with poor survival; thus, it is important to understand their pathophysiology. Furthermore, diagnosing a benign pleural pathology always harbors the uncertainty of a false-negative diagnosis for physicians and pathologists, especially for the group of non-specific pleuritis. This review aims to present the role of the inflammation in the development of benign pleural effusions, with a special interest in their pathophysiology and their association with malignancy.

show abstract

Malignant peritoneal mesothelioma and Crohn disease

Cited by 20 publications

References 47 publications

Progression of Peritoneal Mesothelioma In Situ to Invasive Mesothelioma Arising in the Setting of Endometriosis With Germline BAP1 Mutation: A Case Report

Progression of Peritoneal Mesothelioma In Situ to Invasive Mesothelioma Arising in the Setting of Endometriosis With Germline BAP1 Mutation: A Case Report

Time-Sequential Monitoring of the Early Mesothelial Reaction in the Pleura after Cryoinjury

Inflammation of the Pleural Cavity: A Review on Pathogenesis, Diagnosis and Implications in Tumor Pathophysiology

Contact Info

Product

Resources

About