Malignant nerve sheath tumour arising in a benign ancient schwannoma

Rasbridge, S. A.; Browse, N L; Tighe, J. R.; Fletcher, Christopher D.�M.

doi:10.1111/j.1365-2559.1989.tb02189.x

Cited by 57 publications

(24 citation statements)

References 3 publications

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“…None of the cases of Woodruff et al (8) and McMenamin et al (9) showed the malignant component in an interlacing, fasciculated spindle cell tumor. Review of the available literature revealed only a few cases similar to our case (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11).…”

Section: Discussionsupporting

confidence: 49%

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Malignant Transformation of Intrathoracic Ancient Neurilemmoma in a Patient without Von Recklinghausen's Disease

et al. 2003

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Malignant transformation of a neurilemmoma is an exceedingly rare event. We describe a case of intrathoracic ancient neurilemmoma undergoing a malignant change in a 39-yr-old man. The patient presented with right flank and chest pain for several months. Plain radiography and CT scan of the chest showed a soft tissue mass lesion at the extrapleural space with erosion of surrounding ribs at the right basal lung area. The excised mass was encapsulated and measured 4.5 x 3.5 x 2.3 cm. The cut surface showed grayish-white and glistening with a focal cystic change and hemorrhage. Necrosis was not seen. Histologically, the tumor showed the features of classic neurilemmoma composed of the Antoni type A and B areas with perivascular hyalinization. In addition, obviously histo-logically malignant foci manifested by presence of markedly increased cellularity with fascicular arrangement, active mitotic activity, hyperchromasia, and gradual loss of original neurilemmomatous feature were noted.

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Section: Discussionsupporting

confidence: 49%

“…Review of the available literature revealed only a few other similar cases documenting malignant transformation of a solitary benign neurilemmoma in a patient without von Recklinghausen's disease (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11). We report a case of intrathoracic ancient neurilemmoma undergoing a malignant change in a 39-yr-old man.…”

Section: Introductionmentioning

confidence: 92%

Malignant Transformation of Intrathoracic Ancient Neurilemmoma in a Patient without Von Recklinghausen's Disease

et al. 2003

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“…There have been less than ten reports in the literature of malignant lesions arising from schwannomas [23-25] although some argue that these malignant tumours may arise de novo [7] rather than having undergone secondary anaplastic change [19,26] and that recurrence after resection may actually be due to incomplete excision [27]. …”

Section: Discussionmentioning

confidence: 99%

Benign Ancient Schwannoma of the abdominal wall: An unwanted birthday present

et al. 2010

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BackgroundThere has been a recent growth in the use of whole body Computerised Tomography (CT) scans in the private sector as a screening test for asymptomatic disease. This is despite scant evidence to show any positive effect on morbidity or mortality. There has been concern raised over the possible harms of the test in terms of radiation exposure as well as the risk and anxiety of further investigation and treatment for the large numbers of benign lesions identified.Case PresentationA healthy 64 year old lady received a privately funded whole body CT scan for her birthday which revealed an incidental mass in the right iliac fossa. This was investigated with further imaging and colonoscopy and as confident diagnosis could not be made, eventually excised. Histology demonstrated this to be a benign ancient schwannoma and we believe this to be the first reported case of an abdominal wall schwannoma in the English literatureConclusionsAncient schwannomas are rare tumours of the peripheral nerve sheaths more usually found in the head, neck and flexor surfaces of extremities. They are a subtype of classical schwannomas with a predominance of degenerative changes. Our case highlights the pitfalls of such screening tests in demonstrating benign disease and subjecting patients to what turns out to be unnecessary invasive investigation and treatment. It provides evidence as to the consequences of the large number of false positive results that are created by blind CT scanning of asymptomatic patients i.e. its tendency to detect pseudodiesease rather than affect survival rates. Should the number of scans increase there may be an unnecessary burden on NHS resources due to the large numbers of benign lesions picked up, that are then referred for further investigation.

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“…Maligne Transformationen sind äußerst selten [26]. Immunhistochemisch zeigt sich wie bei den anderen Schwannomen eine homogene Positivität auf das S-100-Protein [13].…”

Section: Hno 1•2001 56unclassified

Degenerativ verändertes parapharyngeales Schwannom "ancient schwannoma". Fallbericht und Literaturübersicht

Walther

Mentzel²,

Sens

et al. 2001

HNO

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Schwannomas are rare, slow-growing, benign neoplasms derived from the schwann cells of the nerve sheath of peripheral nerves. Extracranial schwannomas are most frequently localized within the extremities or the head and neck region. For example, they are common in the skull base, the carotid sheath, and the parapharyngeal space. Beneath several histological variants, schwannomas showing prominent degenerative changes (so-called,,ancient schwannomas") are exceedingly rare. Histopathological features, such as degenerative changes and nuclear atypias in ancient schwannomas, may be easily confused with malignant mesenchymal neoplasm.We present the case of a 32-year-old female who required surgery for a parapharyngeal neoplasm. Histological examination revealed features of an ancient schwannoma.

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Malignant nerve sheath tumour arising in a benign ancient schwannoma

Abstract: A malignant nerve sheath tumour arising in a longstanding benign schwannoma in a 75-year-old woman is described. Malignant change of this kind is extremely rare; there appear to be only four convincing previously reported cases.

Cited by 57 publications

References 3 publications

Malignant Transformation of Intrathoracic Ancient Neurilemmoma in a Patient without Von Recklinghausen's Disease

Malignant Transformation of Intrathoracic Ancient Neurilemmoma in a Patient without Von Recklinghausen's Disease

Benign Ancient Schwannoma of the abdominal wall: An unwanted birthday present

Degenerativ verändertes parapharyngeales Schwannom "ancient schwannoma". Fallbericht und Literaturübersicht

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