Malignant ossifying fibromyxoid tumor of the tongue: case report and review of the literature

Ohta, Kouji; Taki, Masayuki; Ogawa, Ikuko; Ono, Shigehiro; Mizuta, Keiko; Fujimoto, Shinichi; Takata, Takashi; Kamata, Nobuyuki

doi:10.1186/1746-160x-9-16

Cited by 16 publications

(20 citation statements)

References 13 publications

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“…Our patient also had disease in lower limb. From clinical perspective, it is a gradually growing mass which is not painful; this neoplasm mostly arises in the age group of 40–70 years and men is dominant in disease gender distribution 2 7. The patient’s clinical presentation in our case reports is consistent with the reported literature.…”

Section: Discussionsupporting

confidence: 85%

“…In 1989, it was described by Enzinger et al . According to them, 70% of cases are present in upper and lower limbs with subcutaneous tissue involvement and majority of cases reported are benign 1 2 5 6. Our patient also had disease in lower limb.…”

Section: Discussionmentioning

confidence: 55%

“…This tumour may show local recurrence but it is very rarely found to metastasise in distant body regions. The local recurrence rate of OFMT is 20%–27% 1 2…”

Section: Introductionmentioning

confidence: 99%

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Ossifying fibromyxoid tumor: a rare case

Saeed¹,

Din

Hilal

2019

BMJ Case Rep

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Ossifying fibromyxoid tumour (OFMT) is a rarely occurring soft tissue neoplasm of mesenchymal origin. It is a rarely found tumour with intermediate behaviour and differentiation. Although it is mostly benign, malignant variants also exist. We are presenting a case of 32-year-old man presented in clinic with complaints of painless swelling in left distal thigh. After reviewing his X-ray, a diagnostic biopsy was planned which came out to be suspicious of solitary fibrous tumour. Other radiological workup was done and the patient was planned to undergo wide margin excision. The final histopathology showed a diagnosis of OFMT of soft tissue, atypical variant. The patient is under follow-up and is disease free. This type of tumour possesses potential of local recurrence and metastases; therefore, it is important to keep a long-term follow-up of patient.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 55%

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Ossifying fibromyxoid tumor: a rare case

Saeed¹,

Din

Hilal

2019

BMJ Case Rep

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“…Oral lesions are even rarer and have been reported to occur in the gingiva, palatal mucosa, and tongue. A total of 8 confirmed cases of oral cavity OFMT have been published [ 4 – 7 , 17 , 24 , 25 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

Ossifying Fibromyxoid tumor of soft parts in head and neck: case report and literature review

Velasco

Zhang

et al. 2018

Diagn Pathol

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BackgroundOssifying fibromyxoid tumor of soft parts (OFMT), is a rare but morphologically distinctive neoplasm of uncertain histogenesis that most frequently affects middle-aged male adults. Clinically, it usually presents as a slowly enlarging, small, circumscribed mass, which in most cases is painless. OFMT is most frequently found within the subcutaneous tissues of extremities or trunk, and rarely in the oral/head and neck region. We present an unusual case of this tumor in the submandibular region, and, based on the current medical literatures this is probably the first case described in this anatomical location.Case presentationA 32-year-old male presented to our outpatient clinic with a right submandibular mass with 1-year of evolution. Excisional biopsy showed that it was characterized by ossification along the periphery of the lesion. The neoplastic cells were spindle-like with scant eosinophilic cytoplasm. These cells were arranged with uniform cell-to-cell space in a fibromyxoid stroma. Small and large clusters of calcifications were present within the tumor. Immunohistochemically, the case showed positive staining of S-100 protein, vimentin, nestin, calponin, SMA, GFAF, desmin, INI-1, caldesmon, and CD34. It also showed negative staining of CK, CK7, CK8/18, NF, and EMA. About 2% of neoplastic cells showed positive staining of Ki67. Based on these features, the final pathological diagnosis was OFMT.ConclusionsIt is hoped that a greater understanding of OFMT in the head and neck region will avoid potential misdiagnosis, and contribute to determining the correct management, which appears to be complete surgical excision with close follow-up for recurrence surveillance.

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“…It was cranially reported in the ethmoid sinus in a newborn as well [5,6]. Malignant transformation was reported in the tongue [7]. OFMT is a borderline or low-grade malignant lesion.…”

Section: Discussionmentioning

confidence: 99%

Ossifying Fibromyxoid Tumor of the Posterior Maxilla: A Rare Case Report and Literature Review

Ottoman¹

2015

ICPJL

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This paper reports a very unusual site of ossifying fibromyxoid tumor (OFMT) and review the medical literature. In the maxillofacial region, OFMT has been rarely reported. However, malignant OFMT was recently traced in the tongue. Clinicians and maxillofacial pathologists should pay a rapt attention to such an innocent looking lesion that can be easily confused with the ossifying fibrous epulis. This holds true when OFMT is encountered in the gnathions.Keywords: Ossifying Fibromyxoid Tumor; Gnathic Lesions; Fibro-Osseous Lesions and trabeculae of ovoid cells swimming in a fibromyxoid stroma. OFMT was classified as "typical" and "atypical". Histologically, the presence of high cellularity or high nuclear grade, with mitotic activity >2 mitotic figures per 50 high power fields revealed a statistically significant potential for a malignant behavior. This find is characteristic of the so-called "atypical" OFMT. It proved not to be only potentially malignant, but also revealed 60% local recurrence rate and 60% metastasis incidence. Even in typical OFMT cases, the recurrence and metastatic rates, 17% and 5%, respectively, make it a lesion of intermediate malignancy. There are no specific immunohistochemical markers for OFMT. It shows a positive reactivity, sometimes, for S-100 and other bone markers [8]. ConsentWritten informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editorin-Chief of this journal.

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Malignant ossifying fibromyxoid tumor of the tongue: case report and review of the literature

Cited by 16 publications

References 13 publications

Ossifying fibromyxoid tumor: a rare case

Ossifying fibromyxoid tumor: a rare case

Ossifying Fibromyxoid tumor of soft parts in head and neck: case report and literature review

Ossifying Fibromyxoid Tumor of the Posterior Maxilla: A Rare Case Report and Literature Review

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