Malignant paraganglioma of frontoethmoidal region

Sharma, Hari Shankar; M, Madhavan; Othman, Nor Hayati; Muhamad, Mahayidin; Abdullah, Jafri Malin

doi:10.1016/s0385-8146(99)00030-9

Cited by 15 publications

(15 citation statements)

References 21 publications

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“…[15] Furthermore, radiotherapy that is used as a mode of treatment has been implicated in its malignant transformation. [1] Diagnostic challenges arises when clinical features as well as imaging modules including CT, MRI and PET are nonspecific, [6] and the typical morphology findings mentioned above are atypical, i.e. lipoblast-like vacuolated cells.…”

Section: Discussionmentioning

confidence: 99%

“…[1] Originating from the neural crest, these vascular tumors may be hormonally active producing adrenocorticotropic hormone (ACTH), parathyroid-related peptide, antidiuretic hormone, intestinal vasoactive peptide or growth hormone, manifesting clinically as Cushing's syndrome, hypercalcemia, inappropriate secretion of antidiuretic hormone syndrome or acromegaly respectively, depending on their neurosecretory granules content. [2] The reported sinonasal paraganglioma are < 5% of all head and neck paraganglioma [3] with a predilection for middle age females, [4] they usually present with history of nasal obstruction associated with [5] or without epistaxis [6] and or very rarely as Cushing's syndrome due to ACTH secretion.…”

Section: Introductionmentioning

confidence: 99%

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Paraganglioma of maxillary sinus associated with Addison’s disease mimicking a vascular tumour: A case report

Al-Kindy

2016

JST

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Paraganglioma of the nasal and paranasal sinuses are quite rare neuroendocrine tumours, usually hormonally inactive, presenting as nasal polyps with or without epistaxis. We present a rare case of a 23-year old male, with Addison's disease, who was referred from endocrinology department with a complaint of right nasal blockage associated with recurrent epistaxis. A provisional clinical diagnosis of vascular tumour was made, computed tomography (CT) and magnetic resonant imaging (MRI) suggested hemangioma/inverted papilloma. However, biopsy reported a highly vascular tissue mimicking angiofibroma, further immunostaining studies with Synaptophysin and S-100 confirmed the diagnosis of paraganglioma. This rare tumour in the paranasal sinuses may mimic vascular tumour and can only be confirmed with histopathological immunostains studies. According to our knowledge, this is first case reported to be associated with Addison's disease in the English literature.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Paraganglioma of maxillary sinus associated with Addison’s disease mimicking a vascular tumour: A case report

Al-Kindy

2016

JST

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“…There is a close anatomic association with the pterygoid ganglion and its branches to the location of the nasal paragangliomas. [6] The origin of nasal cavity paragangliomas is not well-known. Several authors have suggested that paraganglionic tissue is present in the pterygopalatine fossa and usually in close association with arteries and cranial nerves.…”

Section: Discussionmentioning

confidence: 99%

Nasal paraganglioma

Sağlam¹

2014

Praxis of ORL

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Paragangliyomlar, ekstraadrenal otonomik sinir sisteminin nadir nöroendokrin neoplazmalarıdır. Bunlar genellikle karın, göğüs, baş ve boyun bölgesinde benign ve yavaş büyüyen vasküler tümörlerdir. Baş ve boyun paragangliyomu, primer olarak temporal kemikte ve karotis cisimciğin-de bulunur. Burun ve paranazal sinüs paragangliyomları oldukça nadirdir ve çok az olgu sunumu bulunmaktadır. Bu yazıda burun tıkanıklığı ve kanaması eşliğinde nazal paragangliyomu olan 25 yaşında bir kadın olgu literatür verileri eşliğinde sunuldu.Anahtar Sözcükler: Benign; burun tümörü; nöroendokrin tümör; paragangliyom.Paragangliomas are rare neuroendocrine neoplasms of extraadrenal autonomic nervous system. These are usually benign, slow growing vascular tumors found in the abdomen, thorax, head and neck region. Head and neck paraganglioma is primarily located in the temporal bone and carotid body. Paragangliomas of nose and paranasal sinus are extremely rare and a few case reports are available. In this article we report a 25-year-old female patient with nasal paraganglioma suffering from nasal obstruction and nasal bleeding in the light of literature data.

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“…To date, 13 cases of malignant SNPGL with metastasis or intracranial extension have been reported (2,4,(12)(13)(14)(15)(16). The time interval between initial treatment and the occurrence of metastases was variable and has been reported to be as long as 7 years.…”

Section: Discussionmentioning

confidence: 99%