Malignant Peripheral Nerve Sheath Tumor arising from the Spinal Canal in a Cat

Okada, Midori; Kitagawa, Masato; Shibuya, Hisashi; Kanayama, Kiichi; Sato, Tsuneo; Yamamura, Hozumi; Sakai, Takeo

doi:10.1292/jvms.69.683

Cited by 23 publications

(29 citation statements)

References 17 publications

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“…Primarily because of uncertain histogenesis in veterinary medicine, PNSTs are simply divided into benign and malignant variants in the most recent edition of the WHO International Histological Classification of Tumors of Domestic Animals. 8 The published information on PNSTs in cats is limited (Tables 1, 2), with only 10 peer-reviewed articles 1,[5][6][7]11,12,17,19,20,22 spanning 31 years. Each describes either a single case or a series of 7 or fewer cases.…”

Section: Introductionmentioning

confidence: 99%

“…Each describes either a single case or a series of 7 or fewer cases. Seven of these reports include information regarding biologic behavior, 1,5,6,11,12,19,22 and only 5 include immunohistochemistry. 5,11,17,19,20 Two veterinary textbooks 2,4 provide some summarized information regarding PNSTs in the collections of the books' authors, and a third textbook 18 briefly describes a case of perispinal feline PNST.…”

Section: Introductionmentioning

confidence: 99%

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Feline Peripheral Nerve Sheath Tumors

et al. 2009

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Abstract. Feline peripheral nerve sheath tumors are uncommonly reported, and their clinical behavior has not been well documented. Fifty-nine peripheral nerve sheath tumors were collected from 53 cats. All of the tumors involved skin, subcutis, skeletal muscle, and/or mucous membranes. Histologically, the tumors were composed of compact to loosely arranged streams and fascicles of spindled cells with eosinophilic, often wavy cytoplasmic processes; small to occasionally moderate amounts of collagenous to myxoid matrix; and nuclear palisading. Immunohistochemically, all tumors were positive for vimentin and S-100 protein, 44 of 59 were positive for glial fibrillary acidic protein (GFAP), and all were negative for muscle specific actin. The tumors fell into 3 histologic categories: 34 benign tumors with Antoni A areas that were S-100 protein and GFAP positive, 9 benign tumors that lacked Antoni A areas and were S-100 protein positive and GFAP negative, and 16 tumors with features of malignancy. Seventy-five percent of these cases involved the head, neck, or limbs. Recurrent tumors were submitted or tumors were reported to have recurred in 9 cases. Tumor recurrence was reported for all 3 of the histologic subtypes. None was documented as having metastasized.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Feline Peripheral Nerve Sheath Tumors

et al. 2009

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“…Lymphoma, meningioma, peripheral nerve sheath tumor, plasma cell tumor, oligodendroglioma, and others have been reported [3,13,14,17]. These tumors affecting the spinal cord were considered in the differential diagnosis of this cat that presented with neurological signs.…”

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confidence: 90%

“…Meningioma reported in a cat shows no abnormalities on T1WI, slightly hyperintense on T2WI, and non-uniform enhancement with contrast medium [3]. A malignant peripheral nerve sheath tumor reported in a cat showed iso-intensity compared to the spinal cord on T1WI, a mixture of hypo-, iso-, and hyper-intensities on T2WI, and it was unevenly enhanced on Gd-DTPA-enhanced T1WI [17]. Spinal osteosarcoma in dogs reportedly shows iso-or hypo-intensity on T1WI, iso-intensity on T2WI, and non-uniform enhancement with contrast medium, which differs from the present case [10].…”

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confidence: 94%

“…The mass was uniformly enhanced on contrast-enhanced T1WI. In particular, the hypo-intense signal on T2WI is a characteristic finding, because many spinal tumors in cats do not show hypo-intensity on T2WI [3,14,17]. Moreover, osteosarcoma of domestic animals can be classified in greater detail histologically than on imaging, since the diagnosis of the histological subtype depends more on recognizing significant variations in the predominant matrix (osteoblastic, chondroblastic, and fibroblastic) [20].…”

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Magnetic Resonance Imaging and Computed Tomography Findings of Vertebral Osteosarcoma in a Cat

Okada

Kitagawa

Nagasawa

et al. 2009

The Journal of Veterinary Medical Science

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ABSTRACT. An 8-year-old female Persian cat with a gait disorder was brought to our hospital. Pelvic limb mobility had gradually reduced over the preceding 3 months, then rapidly deteriorated 2 weeks before consultation. Signs also occurred in the thoracic limbs. With a tentative diagnosis of neural disease, magnetic resonance imaging and computed tomography were performed. T1-weighted imaging showed isointensity in the seventh cervical vertebra, while T2-weighted imaging revealed hypointensity. Contrast-enhanced T1-weighted imaging revealed a uniformly enhancing mass. Extirpation of the mass relieved the clinical signs, leading to disappearance of the neurological signs. The histopathological examination suggested osteosarcoma. The diagnosis of spinal tumors is more difficult than that of tumors of the appendicular skeleton, because the radiographic diagnosis is difficult, and various diseases are suspected from the neurological signs. Radiologic evaluation of human patients who present with osseous vertebral lesions often includes radiography, computed tomography (CT), and magnetic resonance imaging (MRI). Because of the complex anatomy of the vertebrae, CT is more useful than conventional radiography for evaluating lesion location and analyzing bone destruction and condensation [18]. On the other hand, MRI has been found to be valuable in evaluating lesion location and volume, revealing tumor extent, defining its relationship with the vertebral canal, and showing tissue specificity [7,21]. Moreover, a detailed differential diagnosis can be performed based on the MRI signal [10]. It has been suggested that early diagnosis of vertebral tumors (primary and metastatic) may improve survival [6].Tumors rarely invade cat bones, with an estimated bone tumor incidence of 4.9/100,000 cats [5,8]. Osteosarcoma accounts for approximately 70-80% of malignant primary bone tumors in cats, and it less frequently involves the axial skeleton than the appendicular skeleton [4,8]. Only a few studies have reported vertebral osteosarcoma [11,13,16]. Few studies have reported MRI and CT findings for vertebral osteosarcoma, and more detailed data have not been reported [13].We report herein the case of a cat with cervical vertebral osteosarcoma involving the epidural area and compressing the spinal cord. Surgery was performed after MRI and CT. In the present case, the postoperative course was good. To the best of our knowledge, the detailed findings of MRI or CT for vertebral osteosarcoma in cats have not been published. The clinical signs, imaging findings, and postoperative course for this case are presented.An 8-year-old, neutered female Persian cat weighing 2.9 kg was brought to our hospital with a gait disorder. Ataxia of the pelvic limbs had developed and gradually deteriorated over the preceding 3 months. Signs had also been observed in the thoracic limbs, with rapid deterioration over the previous 2 weeks. On consultation, the cat's general condition was good. However, the right thoracic limb showed inversion. Hematological da...

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Neurologic Emergencies: Spinal Cord

Snyder¹

2010

Feline Emergency and Critical Care Medicine

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Malignant Peripheral Nerve Sheath Tumor arising from the Spinal Canal in a Cat

Cited by 23 publications

References 17 publications

Feline Peripheral Nerve Sheath Tumors

Feline Peripheral Nerve Sheath Tumors

Magnetic Resonance Imaging and Computed Tomography Findings of Vertebral Osteosarcoma in a Cat

Neurologic Emergencies: Spinal Cord

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