Malignant pleural effusion cells show aberrant glucose metabolism gene expression

Lin, Chien‐Chung; Chen, L. C.; Tseng, Vincent S.; Yan, Jing Jou; Lai, Wu‐Wei; Su, Wen; Lin, Cheng‐Chieh; Huang, Chi Ying F.; Su, Wu Chou

doi:10.1183/09031936.00015710

Cited by 28 publications

(20 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, integrins connect cells to components of the extracellular matrix or to counter receptors on other cells mediating cell adhesion, migration, and other cell–cell contact. It is very likely the overexpression of ITGA9 in SCLCs is also linked to the high metastatic nature of lung cancer cells, and ITGA9 has recently been reported to promote tumor cell adhesion and migration [48]. Thus, CD24 and ITGA9 are very likely among the factors that make the SCLC cells highly prone to metastasis.…”

Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: External Qi of Yan Xin Qigong induces cell death and gene expression alterations promoting apoptosis and inhibiting proliferation, migration and glucose metabolism in small-cell lung cancer cells

Yan

Dozmorov

et al. 2011

Mol Cell Biochem

View full text Add to dashboard Cite

Small-cell lung cancer (SCLC) is a highly malignant carcinoma with poor long-term survival. Effective treatment remains highly demanded. In the present study, we demonstrated that External Qi of Yan Xin Qigong (YXQ-EQ) exerted potent cytotoxic effect towards SCLC cell line NCI-H82 via induction of apoptosis. Global gene expression profiling identified 39 genes whose expression was altered by YXQ-EQ in NCI-82 cells. Among them, semi-quantitative RT-PCR and real-time qPCR analyses confirmed that the gene expression levels of apoptotic proteins death-associated protein kinase 2 and cell death-inducing DFFA-like effector b were upregulated, whereas that of oncoproteins DEK and MYCL1, cell migration-promoting proteins CD24 and integrin-alpha 9, and glycolytic enzyme aldolase A were downregulated. These findings suggest that YXQ-EQ may exert anticancer effect through modulating gene expression in a way that facilitates cancer cell apoptosis while represses proliferation, metastasis, and glucose metabolism.

show abstract

Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: External Qi of Yan Xin Qigong induces cell death and gene expression alterations promoting apoptosis and inhibiting proliferation, migration and glucose metabolism in small-cell lung cancer cells

Yan

Dozmorov

et al. 2011

Mol Cell Biochem

View full text Add to dashboard Cite

show abstract

“…Oh et al [30] demonstrated the presence of T k in BM-derived IPCs under high-glucose conditions. Aberrant T k has been reported to participate in glucose metabolism in malignant pleural effusion cells [31]. T k variants and reduced activities of T k enzyme were found in diabetic patients [32-33].…”

Section: Relationship Between Thiamine and Diabetes Mellitusmentioning

confidence: 99%

The Impact of Thiamine Treatment in the Diabetes Mellitus

Lương

Nguyễn

2012

J Clin Med Res

View full text Add to dashboard Cite

Thiamine acts as a coenzyme for transketolase (Tk) and for the pyruvate dehydrogenase and α-ketoglutarate dehydrogenase complexes, enzymes which play a fundamental role for intracellular glucose metabolism. The relationship between thiamine and diabetes mellitus (DM) has been reported in the literature. Thiamine levels and thiamine-dependent enzyme activities have been reduced in DM. Genetic studies provide opportunity to link the relationship between thiamine and DM (such as Tk, SLC19A2 gene, transcription factor Sp1, α-1-antitrypsin, and p53). Thiamine and its derivatives have been demonstrated to prevent the activation of the biochemical pathways (increased flux through the polyol pathway, formation of advanced glycation end-products, activation of protein kinase C, and increased flux through the hexosamine biosynthesis pathway) induced by hyperglycemia in DM.Thiamine definitively has a role in the diabetic endothelial vascular diseases (micro and macroangiopathy), lipid profile, retinopathy, nephropathy, cardiopathy, and neuropathy.

show abstract

“…As PET-CT is becoming more widely used, the research on its use in the diagnosis of pulmonary GGN is increasing (1). In vitro and in vivo experiments have demonstrated that lung cancer cells have higher levels of glucose metabolism as compared with normal tissue cells (19). Furthermore, as an effective means of identification and diagnosis, 18 F-FDG PET-CT is important in the diagnosis of primary lung cancer (20).…”

Section: Discussionmentioning

confidence: 99%

Application of positron emission tomography‑computed tomography in the diagnosis of pulmonary ground‑glass nodules

Pan

Zhou

et al. 2017

Exp Ther Med

View full text Add to dashboard Cite

Abstract. The aim of the present study was to investigate the value of positron emission tomography-computed tomography (PET-CT) using 18 F-fluorodeoxyglucose in the clinical diagnosis of pulmonary ground-glass nodule. In total, 54 patients with pulmonary GGN that were identified by PET-CT examination were selected and confirmed by pathology and clinical diagnosis in hospital between April 2014 and April 2015. The association between PET-CT findings and pathology, and the value of PET-CT were then evaluated. In the 54 patients, solitary pulmonary GGN with a nodule diameter of between 0.6 and 2.0 cm were detected. Amongst them, the PET-CT examination of 42 patients revealed hyper metabolic nodules, and were all mixed GGN type nodules with a diameter >1 cm. The PET-CT examination of the remaining 12 patients demonstrated no evidence of metabolic abnormalities and the nodules in these patients were pure or mixed GGN with a diameter <1 cm (except 2 cases with a diameter ≥1 cm). Furthermore, the diagnoses for all patients were pathologically confirmed by CT-guided needle biopsy or thoracoscopic surgical resection. Amongst them, there were 41 cases of lung adenocarcinoma, 4 cases of fungal infection, 7 cases of inflammation and 2 cases of adenomatoid hyperplasia. Additionally, PET-CT has a lower detection rate for smaller GGN exhibits no clear advantage for pure GGN, but has a higher detection rate for larger GGN. In conclusion, to a certain extent, PET-CT makes up for the shortcomings of traditional imaging and has some clinical value for the diagnosis of GGN.

show abstract

Malignant pleural effusion cells show aberrant glucose metabolism gene expression

Cited by 28 publications

References 37 publications

RETRACTED ARTICLE: External Qi of Yan Xin Qigong induces cell death and gene expression alterations promoting apoptosis and inhibiting proliferation, migration and glucose metabolism in small-cell lung cancer cells

RETRACTED ARTICLE: External Qi of Yan Xin Qigong induces cell death and gene expression alterations promoting apoptosis and inhibiting proliferation, migration and glucose metabolism in small-cell lung cancer cells

The Impact of Thiamine Treatment in the Diabetes Mellitus

Application of positron emission tomography‑computed tomography in the diagnosis of pulmonary ground‑glass nodules

Contact Info

Product

Resources

About