Malignant presternal goitre

Chow, TL; Kwan, Wilson WY; Hui, Joyce YH

doi:10.12809/hkmj133946

Cited by 7 publications

(8 citation statements)

References 3 publications

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“…Invasion to the subcutaneous tissue, larynx, trachea, oesophagus, and recurrent laryngeal nerve was considered as T4 in the Tumor Node Metastasis (TNM) system 1 2. Different from previous reports showing extension to the ventral of thoracic wall,3 4 our case had more rapid period of disease progression. Pathophysiology of sternal extension of thyroid cancer is largely unknown due to limited reported cases.…”

Section: Descriptionmentioning

confidence: 66%

Extrathyroidal extension ventrally to the thoracic wall of a papillary thyroid carcinoma

et al. 2021

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Section: Descriptionmentioning

confidence: 66%

Extrathyroidal extension ventrally to the thoracic wall of a papillary thyroid carcinoma

et al. 2021

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“…Colonic leiomyomas are very rare, accounting for only 3% GI smooth muscle tumors, and usually located in the descending or sigmoid colon [3][4][5][6]. However, polypoid leiomyomas in the colon and rectum are increasingly detected during colonoscopy [7].…”

Section: Discussionmentioning

confidence: 99%

An Asymptomatic Patient with Colonic Leiomyoma

Alkhowaiter,

Alsheikh,

Alotaibi

2023

Case Rep Gastroenterol

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Subepithelial lesions (SELs) originating from muscularis mucosae of the colon are very rare findings on endoscopy. Appropriate management of SELs involves making a correct diagnosis and estimating their malignant potential. In this case study, a 58-year-old Saudi man presented with a small, 8-mm sigmoid polyp during screening colonoscopy. The polyp was removed by hot snare polypectomy and sent to pathology laboratory. Report showed an unremarkable colonic mucosa and underlying well-circumscribed submucosal lesion composed of monotonous spindle cells. Immunohistochemical (IHC) analysis ruled out CD117-/DOG1-positive GIST and confirmed the lesion as leiomyomatous polyp. Colonic leiomyomas are usually benign and often asymptomatic and discovered during CRC screening procedures. Diagnosis is made on histology/IHC analysis since endoscopically they might be indistinguishable from other SELs. Conventional polypectomy is an appropriate treatment for small colonic leiomyoma and these benign lesions typically do not recur.

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“…Substernal goiter is more common due to the negative intrathoracic pressure during inspiration, which can drag down the thyroid along with gravity effect. 4 Presternal goiter, on the other hand, occurs probably due to migration and growth of thyroid cells into the cervical linea alba between the strap muscles, passing by the pretracheal fascia that encloses the thyroid retrosternally. 5 US (ultrasound) is one of the best exams to detect and to characterise the thyroid.…”

Section: Discussionmentioning

confidence: 99%

“…Due to this, goiters usually migrate down into the superior mediastinum -known as substernal goiters. [3][4][5] But in rare case, the thyroid enlargement migrates in an anterior way, in front of the stern, causing the presternal goiter. The pathogenesis behind this type of alternative migration is not known yet.…”

Section: Introductionmentioning

confidence: 99%

Presternal Goiter

Stumpf¹,

Marques²,

Kluthcovsky³

et al. 2019

J Coll Physicians Surg Pak

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An enlarging thyroid normally extends into the mediastinum, resulting in a presternal or substernal goiter, depending on its migration anteriorly or posteriorly, respectively. The first one was a rare entity in medical literature, being previously reported in only 6 cases worldwide. The present case reports a 54-year woman with a presternal goiter. She had a history of partial thyroidectomy due to a colloid goiter in 2004. Her thyroid function revealed subclinical hypothyroidism. No other abnormalities were present in physical exam or in laboratory tests. A resection of the remaining thyroid tissue was made, with great postsurgical recovery. The anatomopathological study revealed a colloid goiter. Such case porpoise is to remember physicians that unusual presentations of ordinary diseases can occur. This report differs on literature, which demonstrated that papillary thyroid carcinoma is the most important cause of presternal goiter. Moreover, unlike previous reports with normal thyroid function, this case is the only one reported with subclinical hypothyroidism.

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Malignant presternal goitre

Cited by 7 publications

References 3 publications

Extrathyroidal extension ventrally to the thoracic wall of a papillary thyroid carcinoma

Extrathyroidal extension ventrally to the thoracic wall of a papillary thyroid carcinoma

An Asymptomatic Patient with Colonic Leiomyoma

Presternal Goiter

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