Malignant sublingual gland tumors: A single‐center retrospective analysis of 79 patients

Abstract

ObjectivesTo analyze and summarize the clinicopathological features, risk factors for cervical nodal metastasis, and prognostic factors of malignant sublingual gland tumors (MSLGT).MethodsPatients diagnosed with MSLGT were retrospectively reviewed from January 2005 to December 2017 at Shanghai Ninth Hospital. The clinicopathological features were summarized, and the correlations between clinicopathological parameters, cervical nodal metastasis, and local–regional recurrence were evaluated using the Chi‐square test. Kaplan–Meier method and Cox regression analysis were performed to assess the survival and independent prognostic factors.ResultsSeventy‐nine patients were included, and the 5‐year overall survival and disease‐free survival rates was 85.7% and 71.7%, respectively. Gender and clinical tumor stage were risk factors for cervical nodal metastasis. Tumor size and pathological lymph node (LN) stage were independent prognostic factors for adenoid cystic carcinoma (ACC) of the sublingual gland; while age, pathological LN stage, and distant metastasis were prognostic factors for patients with non‐ACC of the sublingual gland. Patients with higher clinical stage were more likely to undergo tumor recurrence.ConclusionsMalignant sublingual gland tumors are rare, and neck dissection should be performed in male MSLGT patients with higher clinical stage. Among patients with both ACC and non‐ACC MSLGT patients, pN+ indicate a poor prognosis.

Prognostic factors for sublingual gland carcinoma: a population-based Surveillance, Epidemiology and End Results database study

“…Park et al 11 noted local invasion in 80% of 26 patients that was associated with decreased OS and diseasespecific survival (DSS). Wu et al 12 recently confirmed the impact of tumor stage on survival. Lee et al 13 analyzed 210 patients in the Surveillance, Epidemiology, and End Results (SEER) database and demonstrated the prognostic roles of age, sex, stage, and surgery.…”

“…2 Reports of salivary gland carcinoma are limited given the rarity of the disease. [3][4][5][6][7][8][9][10][11][12] Yu et al 3 described 28 cases that were identified within 60 years in a famous medical center in China. Zdanowski et al 4 studied 12 cases at the Brazilian National Cancer Institute, whereas Kojima et al 5 described 12 patients in 12 Japanese medical institutions.…”

“…Reports of salivary gland carcinoma are limited given the rarity of the disease. 3–12 Yu et al. 3 described 28 cases that were identified within 60 years in a famous medical center in China.…”