Malignant teratoma in the brain. An immunohistochemical study

Nakamura, Yasuhiro; Satō, Tomohiko; Nishimura, Go; Tanimura, Akira; Takahashi, Yasuhiro; Hachisuka, Hiroshi; Masaike, Kozue; Yanai, Toyohide; Hashimoto, H.

doi:10.1002/1097-0142(19850101)55:1<103::aid-cncr2820550117>3.0.co;2-k

Cited by 8 publications

(3 citation statements)

References 13 publications

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“…17 The remaining tumors that warrant consideration are those of germ-cell, neuronal, and glial origin. Tumors of germ-cell origin [18][19][20][21] usually present in childhood as very slowly growing masses in the pineal or suprasellar region. In rare cases, a germ-cell tumor presents in an adult as a teratoma or other lobar mass that tends to contain large, bonelike calcifications.…”

Section: Presentation Of Casementioning

confidence: 99%

“…In rare cases, a germ-cell tumor presents in an adult as a teratoma or other lobar mass that tends to contain large, bonelike calcifications. [19][20][21] It is tempting to make this diagnosis in the present case, because of the peculiar configuration of the calcifications. The history of a tumor in the pineal region in the patient's son raises the question whether this is the first reported case of familial teratoma.…”

Section: Presentation Of Casementioning

confidence: 99%

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Case 12-1997

Paydarfar¹

1997

N Engl J Med

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A 50-year-old right-handed woman with multiple sclerosis was admitted to the hospital because of an enlarging intracranial mass.The patient had been well until 15 years earlier, when she began to have bifrontal headaches with reduced visual acuity and was found to have bilateral papilledema. A computed tomographic (CT) scan of the brain was normal. A diagnosis of pseudotumor cerebri was made, and a lumbar puncture was performed, with a gradual resolution of symptoms.The patient was subsequently well until six years before admission, when a left footdrop developed and she began to experience numbness in the fingertips. A magnetic resonance imaging (MRI) study of the brain showed multiple hyperintense lesions in the white matter characteristic of demyelinating plaques on proton-density-weighted images ( Fig. 1), as well as a large mass in the right inferior frontal lobe on T 2 -weighted images (Fig. 2). A CT scan of the brain showed linear foci of calcification within the mass (Fig. 3). Brain-stem auditory evoked responses, visual evoked responses, and somatosensory evoked potentials were normal. The patient was admitted to another hospital, where corticosteroids were administered intravenously for five days, with resolution of symptoms.Thereafter, she remained well. Thirty-nine days before admission to this hospital, a cranial MRI examination, performed before and after the administration of gadolinium, showed a slightly larger number of hyperintense foci involving the periventricular white matter, corpus callosum, corona radiata, and right and left centrum semiovale and cerebellar hemispheresfindings typical of multiple sclerosis; a punctate plaque, which was enhanced after the administration of gadolinium, was present in both the right and the left centrum semiovale. The right-frontal-lobe mass (Fig. 4), which was centered in the subcallosal region and involved the gyrus rectus and orbitofrontal gyri, affected both gray and white matter. The mass was heterogeneously hypointense on T 1 -weighted images and hyperintense on T 2 -weighted images, with little or no enhancement after the administration of gadolinium. It contained several small cysts and linear hypointense foci that corresponded to the foci of calcification. A hyperintense signal on T 2 -weighted images, representing vasogenic edema and possibly a tumor, extended superiorly into the anterior aspect of the cingulate gyrus and inferiorly into the temporal lobe. There was a mass effect, with a midline shift to the left. The overlying calvaria was minimally thinned. The patient was referred to this hospital.She worked in a clerical position and was receiving Figure 1. Axial Proton-Density-Weighted MRI Scan Obtained Six Years before Admission.The multiple hyperintense periventricular foci are typical of multiple sclerosis. Expansion and hyperintensity of the right cingulate gyrus extend from the right inferior frontal mass (arrow).The New England Journal of Medicine Downloaded from nejm.org on August 12, 2015. For personal use only. No other uses without p...

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Section: Presentation Of Casementioning

confidence: 99%

Section: Presentation Of Casementioning

confidence: 99%

Case 12-1997

Paydarfar¹

1997

N Engl J Med

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“…These tumor markers are useful for classifying the group of tumors, evaluating the response to initial therapy, and also detecting the early recurrence of intracranial tumors. 6 , 7) …”

Section: Commentnmentioning

confidence: 99%

A Malignant Mixed Germ Cell Tumor Originating from the Pituitary Gland with a Suprasellar Extension: A Case Report

Lim

Chung

Kim

et al. 1986

Korean J Intern Med

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A case of an intracranial tumor in a 26-year old woman with symptoms of hypopituitarism, and visual disturbance is presented. The primary site has been verified by the clinical presentations and the hormonal and the neurological studies as originating from the pituitary gland with extension to the suprasellar area. Histologically, the tumor contains elements that demand its interpretation as a malignant teratoma. In a tumor marker study, the aFP level was elevated, suggestive of an endodermal sinus tumor component. We report this case as a mixed germ cell tumor originating from the pituitary gland with a suprasellar extension and a malignant transformation from a benign component.

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