Malignant transformation in 1458 patients with potentially malignant oral mucosal disorders: a follow‐up study based in a Taiwanese hospital

Hsue, Shue-Sang; Wang, Wen-Chen; Chen, Chung-Ho; Lin, Chun-Liang; Chen, Yuk-Kwan; Lin, Li‐Min

doi:10.1111/j.1600-0714.2006.00491.x

Cited by 237 publications

(210 citation statements)

References 24 publications

(31 reference statements)

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“…The female to male ratio in this study was 1.37:1, unlike the other studies [5,10,15,16]. This can be due to the increase of the number of exposed women to the factors of risks currently, such as the tobacco use and the consumption of alcohol.…”

Section: Discussioncontrasting

confidence: 46%

“…These lesions show variable clinical presentation such as leukoplakia, erythroplakia, submucous fibrosis, actinic keratosis, palatal lesions in reverse smokers, lichen planus, discoid lupus erythematosus, and hereditary disorders such as dyskeratosis congenita and epidermolysis bullosa [1,[5][6][7]. The presence of epithelial dysplasia is generally accepted as one of the most important predictors of malignant development in lesions [1].…”

Section: Introductionmentioning

confidence: 99%

“…In 1995, Lumerman et al [13] reported that 6.6% to 36% of epithelial dysplasias may transform to oral squamous cell carcinoma. In a recent study [5], the malignant transformation rate of PMD was estimated to be from 1.9% to 5.4%. In accordance with cited studies, Ho et al [8] reported that the risk of transformation of OED to cancer has a range from 1.4% to 7.62% per year.…”

Section: Introductionmentioning

confidence: 99%

“…Oral epithelial dysplasia, not associated with any specific clinical appearance, is a term assigned to the histopathological changes associated with increased risk of malignant transformation [5]. Oral epithelial dysplasia typically presents itself as a predominantly white, red, or mixed white and red mucosal lesion [14].…”

Section: Introductionmentioning

confidence: 99%

“…Conventionally, dysplasia is divided into grades: mild, moderate, and severe [2]. The presence of moderate or severe dysplasia has been accepted to have the greatest likelihood for malignant transformation [5].…”

Section: Introductionmentioning

confidence: 99%

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Epidemiology and correlation of the clinicopathological features in oral epithelial dysplasia: analysis of 173 cases

Pereira

Carvalho

Henriques

et al. 2011

Annals of Diagnostic Pathology

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Oral epithelial dysplasias (OEDs) are potentially malignant disorders characterized by diverse degrees of cellular atypia. The early and careful diagnosis has extreme importance, allowing prevention of the progression to the oral squamous cell carcinoma. This study aimed to determine the epidemiology and then correlate it with the clinicopathological features of OED. One hundred seventy-three cases of oral lesions retrieved from the files of a Service of Pathological Anatomy, covering a 38-year period, were submitted to descriptive statistical analysis through the Pearson χ 2 test. The majority of cases were from affected females (57.9%), with a peak of occurrence in the age group of 41 and 55 years (37.3%), white patients (64.8%), and those with lesions located on the gingiva/alveolar ridge (25.1%). The lesions predominantly presented with white color (56.8%) and were described as nodules (27.4%), with a rough surface (76.7%), an exophytic growth (79.1%), and a sessile base (95.6%). The majority of the lesions with degree of mild (34.6%) and moderate (34.9%) OED had clinical diagnosis of leukoplakia, whereas 33.3% of the lesions with degree of severe had clinical diagnosis of squamous cell carcinoma (P b .05). Tobacco use was the risk habit more related with OED (42.6%) (P N .05). The knowledge of OED epidemiology and clinical features provide a better understanding of the factors that possibly are associated with the malignant transformation of OED. Furthermore, these results contribute to supporting a prompt and accurate recognition of these lesions in clinical practice.

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Section: Discussioncontrasting

confidence: 46%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Epidemiology and correlation of the clinicopathological features in oral epithelial dysplasia: analysis of 173 cases

Pereira

Carvalho

Henriques

et al. 2011

Annals of Diagnostic Pathology

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Clinical and Histologic Features Associated With Malignant Transformation of Oral Cavity Dysplasia Managed at a Single North American Institution

Tang

Amadio

Ridge

2022

JAMA Otolaryngol Head Neck Surg

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IMPORTANCEReports characterizing clinical and histologic features associated with a higher risk for development of malignant lesions in the background of an oral potentially malignant disorder have largely reflected East Asian populations. Long-term studies among the North American population are rare.OBJECTIVE To evaluate risk of malignant transformation (MT) of oral dysplastic lesions by investigating the demographic, social, clinical, and histologic factors that may be associated with an increased rate as well as a decreased time to MT. DESIGN, SETTING, AND PARTICIPANTSThis was a retrospective cohort study with medical record review at a single institution from January 1, 2000, to December 31, 2019, with follow-up for 20 years. Patients were excluded if they were younger than 18 years, the first biopsy diagnosis showed cancer, biopsies were never performed, biopsies were taken from sites outside of the oral cavity, there was no additional follow-up after the first visit, or the biopsy specimen was not characterized on the spectrum of dysplasia.EXPOSURES Diagnosis of leukoplakia of oral mucosa, unspecified lesions of oral mucosa, or other disturbances of oral epithelium. MAIN OUTCOMES AND MEASURESMain outcome measures included MT rate and time to MT as well as demographic, social, clinical, physical, and histologic features associated with MT.RESULTS Thirty-eight of 264 lesions (14%) in 241 patients (132 men and 109 women; mean [SD] age, 64 [13] years) underwent MT. Of the 38 lesions that underwent MT, 19 (50%) underwent transformation by 424 days, 28 (75%) by 870 days, and 34 (90%) by 1600 days. Nodularity, friability, and mass effect were more commonly observed in malignant lesions (

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The Oral Cavity and Lips

Scully

2004

Rook's Textbook of Dermatology

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Malignant transformation in 1458 patients with potentially malignant oral mucosal disorders: a follow‐up study based in a Taiwanese hospital

Abstract: These results indicate that patients with pre-malignant oral lesions need long-term follow up.

Cited by 237 publications

References 24 publications

Epidemiology and correlation of the clinicopathological features in oral epithelial dysplasia: analysis of 173 cases

Epidemiology and correlation of the clinicopathological features in oral epithelial dysplasia: analysis of 173 cases

Clinical and Histologic Features Associated With Malignant Transformation of Oral Cavity Dysplasia Managed at a Single North American Institution

The Oral Cavity and Lips

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